Stabilizing the Retromer Complex in a Human Stem Cell Model of Alzheimer's Disease Reduces TAU Phosphorylation Independently of Amyloid Precursor Protein.

Developing effective therapeutics for complex diseases such as late-onset, sporadic Alzheimer's disease (SAD) is difficult due to genetic and environmental heterogeneity in the human population and the limitations of existing animal models. Here, we used hiPSC-derived neurons to test a compound that stabilizes the retromer, a highly conserved multiprotein assembly that plays a pivotal role in trafficking molecules through the endosomal network. Using this human-specific system, we have confirmed previous data generated in murine models and show that retromer stabilization has a potentially beneficial effect on amyloid beta generation from human stem cell-derived neurons. We further demonstrate that manipulation of retromer complex levels within neurons affects pathogenic TAU phosphorylation in an amyloid-independent manner. Taken together, our work demonstrates that retromer stabilization is a promising candidate for therapeutic development in AD and highlights the advantages of testing novel compounds in a human-specific, neuronal system

An Empirical Assessment of Divorce Law in Indonesia

A discussion of the effect of the marriage Act 1974 against divorce behavior Muslim community in Indonesia can be said to be rare. Various writings that discuss the application of these laws focus more on aspects of institutional, legal and political.DOI: 10.15408/sdi.v4i4.76

Strong beaming of microwave surface waves with complementary split-ring-resonator arrays (article)

This is the final version of the article. Available from Springer Nature via the DOI in this record.The dataset associated with this article is located in ORE at: https://doi.org/10.24378/exe.584A thin copper sheet, populated by an array of complementary split ring resonators, presents strong surface wave beaming in orthogonal directions at two distinct frequencies. This simple array is significantly thinner than existing single frequency beaming surfaces. The observed beaming frequencies are associated with the two lowest resonance modes of the split rings, and the beams are subwavelength in width and approximately non-diverging. The beaming is analysed through comparison of near-field scans of the surface-normal electric fields with numerical simulations.The authors wish to acknowledge financial support from the Engineering and Physical Sciences Research Council (EPSRC) of the United Kingdom, via the EPSRC Centre for Doctoral Training in Metamaterials (Grant No. EP/L015331/1) and also from QinetiQ

Effects of alternative electricity rates and rate structures on electricity and water use on the Colorado High Plains

October 1984.Contract report for Colorado Commission on Higher Education.Bibliography: pages 60-62

Gender Specific Disruptions in Emotion Processing in Younger Adults with Depression

Background: One of the principal theories regarding the biological basis of major depressive disorder (MDD) implicates a dysregulation of emotion-processing circuitry. Gender differences in how emotions are processed and relative experience with emotion processing might help to explain some of the disparities in the prevalence of MDD between women and men. This study sought to explore how gender and depression status relate to emotion processing. Methods: This study employed a 2 (MDD status) × 2 (gender) factorial design to explore differences in classifications of posed facial emotional expressions (N=151). Results: For errors, there was an interaction between gender and depression status. Women with MDD made more errors than did nondepressed women and men with MDD, particularly for fearful and sad stimuli (Ps Ps P=.01). Men with MDD, conversely, performed similarly to control men (P=.61). Conclusions: These results provide novel and intriguing evidence that depression in younger adults (years) differentially disrupts emotion processing in women as compared to men. This interaction could be driven by neurobiological and social learning mechanisms, or interactions between them, and may underlie differences in the prevalence of depression in women and men. Depression and Anxiety, 2009. Published 2008 Wiley-Liss, Inc

PASSIVE SUPPRESSION OF AEROELASTIC INSTABILITIES OF IN-FLOW WINGS BY TARGETED ENERGY TRANSFERS TO LIGHTWEIGHT ESSENTIALLY NONLINEAR ATTACHMENTS

Theoretical and experimental suppression of aeroelastic instabilities by means of broadband passive targeted energy transfers has been recently studied. A single-degree-offreedom (SDOF) nonlinear energy sink (NES) was coupled to a 2-DOF rigid wing modeled in the low-speed, subsonic regime with quasi-steady aerodynamic theory. The nonlinear attachment was designed and optimized to suppress the critical nonlinear modal energy exchanges between the flow and the (pitch and heave) wing modes, thus suppressing the (transient) triggering mechanism of aeroelastic instability. We performed bifurcation analysis to find regions of robust passive aeroelastic suppression in parameter space. Then, we employed multi-degreeof-freedom nonlinear energy sinks (MDOF NESs) to improve robustness of the aeroelastic instability suppression. Bifurcation analysis by a numerical continuation technique demonstrated that controlling the occurrence of a limit point cycle (LPC or saddle-node) bifurcation point above a Hopf bifurcation point is crucial to enhancing suppression robustness. MDOF NESs not only can enhance robustness of suppression against even strong gust-like disturbances, but they require lower NES mass compared to SDOF NES designs. The validity of the theoretical findings was proven by a series of wind tunnel experiments