Residential integration on fair terms for the disadvantaged

This article contributes to normative debates about residential segregation and its relationship to inequality. It defends a position often disregarded in literature: that there is merit to advancing residential integration through some scenarios where advantaged individuals move to disadvantaged areas. It develops this case in dialogue with three other views. In relation to advocates of addressing the inequalities of residential segregation through redistribution, it defends integration as a means of tackling social and political factors that sustain injustice. It challenges those who defend relocating disadvantaged individuals to advantaged areas by highlighting the burdens and demand for cultural assimilation this imposes on the disadvantaged. It considers the worry that advantaged individuals relocating to disadvantaged areas harbours the problematic features of gentrification. It responds that these concerns, while important in some cases, do not arise in all scenarios of this kind

Alternative first exon splicing regulates subcellular distribution of methionine sulfoxide reductases

BACKGROUND: Methionine sulfoxide reduction is an important protein repair pathway that protects against oxidative stress, controls protein function and has a role in regulation of aging. There are two enzymes that reduce stereospecifically oxidized methionine residues: MsrA (methionine-S-sulfoxide reductase) and MsrB (methionine-R-sulfoxide reductase). In many organisms, these enzymes are targeted to various cellular compartments. In mammals, a single MsrA gene is known, however, its product is present in cytosol, nucleus, and mitochondria. In contrast, three mammalian MsrB genes have been identified whose products are located in different cellular compartments. RESULTS: In the present study, we identified and characterized alternatively spliced forms of mammalian MsrA. In addition to the previously known variant containing an N-terminal mitochondrial signal peptide and distributed between mitochondria and cytosol, a second mouse and human form was detected in silico. This form, MsrA(S), was generated using an alternative first exon. MsrA(S) was enzymatically active and was present in cytosol and nucleus in transfected cells, but occurred below detection limits in tested mouse tissues. The third alternative form lacked the active site and could not be functional. In addition, we found that mitochondrial and cytosolic forms of both MsrA and MsrB in Drosophila could be generated by alternative first exon splicing. CONCLUSION: Our data suggest conservation of alternative splicing to regulate subcellular distribution of methionine sulfoxide reductases

Plausibility of Image Reconstruction Using a Proposed Flexible and Portable CT Scanner

The very hot and power-hungry x-ray filaments in today's computed tomography (CT) scanners constrain their design to be big and stationary. What if we built a CT scanner that could be deployed at the scene of a car accident to acquire tomographic images before moving the victim? Recent developments in nanotechnology have shown that carbon nanotubes can produce x-rays at room temperature, and with relatively low power needs. We propose a design for a portable and flexible CT scanner made up of an addressable array of tiny x-ray emitters and detectors. In this paper, we outline a basic design, propose a strategy for reconstruction, and demonstrate the feasibility of reconstruction using experiments on a software simulation of the flexible scanner. These simulations show that reconstruction quality is stable over a wide range of scanner geometries, while progressively larger errors in the scanner geometry induce progressively larger errors. We also raise a number of issues that still need to be overcome to build such a scanner.This work was supported by funding from the Natural Sciences and Engineering Research Council of Canada (NSERC), the Canada Foundation for Innovation, and the Ontario Innovation Trust

Measuring Career Aspirations in Korean College Women

The purpose of this study was to translate and evaluate the Korean version of the Career Aspirations Scale Revised (K-CASR). The American version of the Career Aspirations Scale-Revised (Gregor & O'Brien, 2013) was translated into Korean using multiple translation strategies. The psychometric properties of the K-CASR were examined with data from 377 college women in Korea. The confirmatory factor analysis indicated that the 18-item version of the K-CASR had good model fit with the hypothesized three factor structure (achievement aspirations; leadership aspirations, educational aspirations). The K-CASR also exhibited moderately high internal consistency and stability. Convergent validity was supported by positive correlations with achievement motivation, career orientation, and career goal engagement. Implications for future research and counseling were discussed

Registering a Non-Rigid Multi-Sensor Ensemble of Images

Image registration is the task of aligning two or more images into the same reference frame to compare or distinguish the images. The majority of registration methods deal with registering only two images at a time. Recently, a clustering method that concurrently registers more than two multi-sensor images was proposed, dubbed ensemble clustering. In this thesis, we apply the ensemble clustering method to deformable registration scenario for the first time. Non-rigid deformation is implemented by a FFD model based on B-splines. A regularization term is added to the cost function of the method to limit the topology and degree of the allowable deformations. However, the increased degrees of freedom in the transformations caused the Newton-type optimization process to become ill-conditioned. This made the registration process unstable. We solved this problem by using the matrix approximation afforded by the singular value decomposition (SVD). Experiments showed that the method is successfully applied to non-rigid multi-sensor ensembles and overall yields better registration results than methods that register only 2 images at a time. In addition, we parallelized the ensemble clustering method to accelerate the performance of the method. The parallelization was implemented on GPUs using CUDA (Compute Unified Device Architecture) programming model. The GPU implementation greatly reduced the running time of the method

Career Barriers of College Women across Racial/Ethnic Groups: Examination of The Perception of Barriers Scale

The purpose of the study was to examine the factor structure, measurement invariance, and psychometric properties of a commonly used measure of perceived career barriers (The Perception of Barriers Scale; Luzzo & McWhirter, 2001) with a sample of racially diverse college women. The results supported a nine-factor structure of the Perception of Barriers Scale indicating different sources of barriers. In general, configural, metric, and scalar invariance of the Perception of Barriers subscales were found across Asian American, African American, Latina American, and White American college women for the nine-factor structure. All three groups of women of color reported higher career barriers due to racial discrimination, higher educational barriers due to finances concerns, and higher educational barriers due to lack of confidence and skills than White women. The results also demonstrated the potential difference in salient barriers across Asian American, African American, and Latina American women. The reliability estimates were satisfactory and construct validity was supported by negative associations among the scores on several Perception of Barriers subscales and a career-self-efficacy measure. The findings suggested that college women experience barriers from various sources when pursuing their career and educational goals