3,204 research outputs found
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Never easy to say "sorry" : exploring the interplay of crisis involvement, brand image and message framing in developing effective crisis responses
textPlanning and executing a crisis response strategy that includes successful and effective communication with stakeholders are essential for companies, organizations and governments in order to maintain their reputations and sustain brands following a crisis. To determine the effectiveness of crisis response communication in terms of consumers’ evaluation and information processing, this study experimentally examined the impact of crisis involvement and brand image and interaction effect in a corporate product harm crisis. Using fictitious scenarios to manipulate crisis involvement, brand image, and message framing, this study examines the effect of crisis response strategies (i.e., apology) on post-crisis attitudes toward a crisis brand and apology message, future purchase intention, and intention to engage in negative eWOM. Specifically, the study attempts to identify whether the interplay between these factors would increase the effectiveness of a company’s crisis response regarding consumers’ favorable attitudes and behavioral intentions. The results of the present research showed that the overall three-way interaction between crisis involvement, brand image, and message framing is significant. First, in the case of high crisis involvement, the combination of rational framing and symbolic brand image increases the effectiveness of the apology message, while the combination of emotional framing of crisis communication and functional brand image increases the effectiveness of the apology message. In contrast, in the case of low crisis involvement, the combination of rational framing and functional brand image increases the effectiveness of the apology message, while the combination of emotional framing and symbolic brand image increases the effectiveness of the apology message. In addition, the study suggests that crisis involvement and brand image have a primary effect on the efficacy of the apology message from the crisis company in terms of attitude towards the crisis brand and purchase intention. The study has significant practical implications in that the results indicate that practitioners can alleviate the consequences suffered in a crisis by employing a crisis response strategy that properly aligns crisis type with level of involvement. Following a crisis, it is necessary to communicate with consumers using proper response messaging that takes into consideration consumers’ crisis involvement, brand image and message framing.Advertisin
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"Christian conversion" as a radical philosophical turn : Lukan literary efforts in describing Paul's "Conversion" in Acts 9, 22, and 26
textThe present report analyzes the three Lukan accounts on Paul's "conversion" in Acts 9:1-31, 22:6-21, and 26:12-17 in consideration of the contemporary literary milieu of the Greek philosophical and Hellenistic Jewish discourses on one's "conversion," i.e., a radical change as discarding his/her former thoughts. Through this analysis, I argue that Luke redescribed Paul’s experience of the risen Christ as a "conversion," and in doing so, constructed the concept of "Christian conversion" as a radical philosophical turn. In his undisputed letters, we find that Paul understood his encounter with the risen Christ as a "calling" within the Hebrew prophetic tradition. On the contrary, Luke stresses the radical rupture between Paul's before and after the revelatory experience by making it an immediate change and adding details such as Saul’s activities as a persecutor and his name change. In recasting Paul's experience as a "conversion," Luke utilized two main literary elements to characterize the nature of his experience as a radical cognitive shift. One is the metaphor of transition from darkness to light, which is applied to Paul in Acts 9 and 22 as he becomes blind after seeing the light and to the gentile conversion in Acts 26 that they should "turn from darkness to light (v.18)." Another is the notion of repentance that Luke applies directly to Paul in Acts 9 and 22 in his baptism and to the gentile conversion in Acts 26. These two motifs are what we often find in the Greek philosophical and Hellenistic Jewish texts discussing one's radical cognitive shift to a new philosophical system or the Jewish monotheism upon the revelation of a true teaching. By applying these motifs to the "conversion" of Saul, Luke identifies Paul's experience and "Christian conversion" as a radical philosophical turn from ignorance to a correct understanding of the messiah and the God. With the Lukan literary and conceptual efforts in Acts, Paul now becomes a paradigmatic "Christian convert" and a philosopher in Acts whose radical cognitive shift can be followed by Jews and gentiles in the Roman world.Religious Studie
The Study of International Regimes
Hundreds or even thousands of international legal instruments on "the environment" are in existence. What happens to international environmental agreements once they are signed, and how does the process of implementing such agreements influence their effectiveness? These are the questions that motivate the IIASA project "Implementation and Effectiveness of International Environmental Commitments (IEC)". Research teams are examining these questions from many angles and with different methods.
In this paper, the authors survey the literature on international "regimes". Regimes are social institutions that influence the behavior of states and their subjects. They consist of informal and formalized principles and norms, as well as specific rules and procedures. The term is explicitly broad and captures the unwritten understandings and relationships, as well as the formal legal agreements, that influence how states and individuals behave in any given issue-area. Scholarship over the last decade has elaborated how regimes are formed; this paper surveys that work and focuses on more recent scholarship that has turned from the formation of regimes to the question of what makes regimes "effective".
The paper is one foundation for IEC's effort to build a database about the characteristics of international regimes. The database will consist of key variables related to the formation and implementation of international agreements and will allow systematic use of historical evidence from a large number of cases. The goal is to make possible the testing of hypotheses and the drawing of general conclusions about which variables are causally linked to "effectiveness". Existing research has led to hypotheses and tests based on single case studies or small samples of cases, but conclusions have been difficult to generalize to other cases because variables are left uncontrolled and the social processes are complex. In contrast, the IEC effort will include all the major variables related to effectiveness. The team will employ experts in each case to perform the coding, thus allowing for assessments (including subjective evaluations) of a wide range of data.
The team is now preparing and testing a data protocol, as well as a manual that describes the major questions in the data protocol and how they should be answered. The protocol and manual will refine the variables we are coding and their relationship to major hypotheses
Metabolic profiling predicts response to anti-tumor necrosis factor α therapy in patients with rheumatoid arthritis
<p>Objective: Anti–tumor necrosis factor (anti-TNF) therapies are highly effective in rheumatoid arthritis (RA) and psoriatic arthritis (PsA), but a significant number of patients exhibit only a partial or no therapeutic response. Inflammation alters local and systemic metabolism, and TNF plays a role in this. We undertook this study to determine if the patient's metabolic fingerprint prior to therapy could predict responses to anti-TNF agents.</p>
<p>Methods: Urine was collected from 16 RA patients and 20 PsA patients before and during therapy with infliximab or etanercept. Urine metabolic profiles were assessed using nuclear magnetic resonance spectroscopy. Discriminating metabolites were identified, and the relationship between metabolic profiles and clinical outcomes was assessed.</p>
<p>Results: Baseline urine metabolic profiles discriminated between RA patients who did or did not have a good response to anti-TNF therapy according to European League Against Rheumatism criteria, with a sensitivity of 88.9% and a specificity of 85.7%, with several metabolites contributing (in particular histamine, glutamine, xanthurenic acid, and ethanolamine). There was a correlation between baseline metabolic profiles and the magnitude of change in the Disease Activity Score in 28 joints from baseline to 12 months in RA patients (P = 0.04). In both RA and PsA, urinary metabolic profiles changed between baseline and 12 weeks of anti-TNF therapy. Within the responders, urinary metabolite changes distinguished between etanercept and infliximab treatment.</p>
<p>Conclusion: The clear relationship between urine metabolic profiles of RA patients at baseline and their response to anti-TNF therapy may allow development of novel approaches to the optimization of therapy. Differences in metabolic profiles during treatment with infliximab and etanercept in RA and PsA may reflect distinct mechanisms of action.</p>
Design optimisation of air-fed full pressurised suits
This article is a post-print version of the published article which may be accessed at the link below.The JET machine and associated facilities require significant maintenance and enhancement installation activities in support of the experimental exploitation programme. A proportion of these activities are within radiological and respiratory hazardous environments. As such, breathing air-fed one-piece pressurised suits provide workers with protection from the inhalation of both airborne tritium and beryllium dust. The design of these suits has essentially developed empirically. There is a practical necessity to improve the design to optimise worker performance, protection and thermal comfort. This paper details the complexity of modeling the three-dimensional thermofluid domain between the inner surface of the suit and under garments that includes mass as well as heat transfer, suiting geometry, human metabolism and respiration and effects of limb movements. The methods used include computational fluid dynamics (CFD), theoretical adaptations of mixed-phase turbulent flow, profile scanning of a suit and actuating life size mannequin and data processing of the images and experimental validation trials. The achievements of the current programme and collaborations are presented in the paper and future endeavors are discussed.The author gratefully acknowledges the loan of the articulated mannequin from the Defence Science and Technology Laboratories. This work was funded jointly by EPSRC and by the European Communities under the contract of Association between EURATOM and UKAEA. The views and opinions expressed herein do not necessarily reflect those of the European Commission. This work was carried out within the framework of EFDA
Reduced maximum capacity of glycolysis in brown adipose tissue of genetically obese, diabetic (db/db) mice and its restoration following treatment with a thermogenic β-adrenoceptor agonist
AbstractThe maximal activities of the key glycolytic enzymes hexokinase and 6-phosphofructokinase, were reduced in brown adipose tissue in db/db mice compared to their lean littermates. Treatment of db/db mice with the thermogenic β-adrenoceptor agonist, BRL 26830, restored normoglycaemia. The only significant increase in activity of hexokinase and 6-phosphofructokinase in the BRL 26830-treated db/db mice occurred in brown adipose tissue where the total tissue activity increased 10- and 11-fold respectively. These changes together with increased 2-deoxyglucose uptake in vivo suggest that brown adipose tissue can play a quantitatively important role in the removal of glucose from the blood
The Chiral Model of Sakai-Sugimoto at Finite Baryon Density
In the context of holographic QCD we analyze Sakai-Sugimoto's chiral model at
finite baryon density and zero temperature. The baryon number density is
introduced through compact D4 wrapping S^4 at the tip of D8-\bar{D8}. Each
baryon acts as a chiral point-like source distributed uniformly over R^3, and
leads a non-vanishing U(1)_V potential on the brane. For fixed baryon charge
density n_B we analyze the bulk energy density and pressure using the canonical
formalism. The baryonic matter with point like sources is always in the
spontaneously broken phase of chiral symmetry, whatever the density. The
point-like nature of the sources and large N_c cause the matter to be repulsive
as all baryon interactions are omega mediated. Through the induced DBI action
on D8-\bar{D8}, we study the effects of the fixed baryon charge density n_B on
the pion and vector meson masses and couplings. Issues related to vector
dominance in matter in the context of holographic QCD are also discussed.Comment: V3: 39 pages, 16 figures, minor corrections, version to appear in
JHEP. V2: references added, typos correcte
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