Coupling of spontaneous changes in muscle sympathetic nerve activity to blood pressure in humans : potential influence of age [abstract]

Previous studies indicate a 5.5 second latency between a burst of muscle sympathetic nerve activity (MSNA) and the resultant peak blood pressure response, which averages up to 3 mmHg. Aging may attenuate α-adrenergic sensitivity, impair baroreflex function, and hence affect the ability to sympathetically modulate blood pressure. Yet a thorough examination of these relationships in older adults has not been performed. Purpose: To compare the relationship between spontaneous changes in MSNA to changes in blood pressure in young and older men

Selective attenuation of carotid-cardiac responses to hypertension at the onset of static handgrip in humans [abstract]

Previous studies have indicated that at the onset of exercise cardiac baroreflex function is reduced in an intensity-dependent manner, which appears to be mediated by a blunted ability to buffer hypertensive challenges. However, whether cardiac baroreflex responses to a hypotensive stimulus are altered at exercise onset is unclear

Insulin-mediated increases in arterial baroreflex control of muscle sympathetic nerve activity following meal intake in humans [abstract]

Animal studies indicate that insulin enhances arterial baroreflex (ABR) control of sympathetic nerve activity (SNA); however, the extent to which these findings can be extrapolated to humans is unknown. To begin to address this, we utilized a mixed meal as a physiological method to evoke sustained increases in plasma insulin