ANTIBIOTIC SUSCEPTIBILITY PATTERN OF ESCHRICHIA COLI ISOLATES FROM CLINICAL SPECIMENS AT PIMS, ISLAMABAD

Background: E. coli is the most common producer of extended spectrum beta lactamase enzyme (ESBL) which confers broad spectrum resistance to antibiotics like penicillin, cephalosporin and monobactum. Methods and Materials: The present study was carried out at Pakistan Institute of Medical Sciences, Islamabad. The marked resistance was viewed against amoxicilline-clavulanic acid, ceftriaxone and ceftazidime. The most effective drugs established were sulbactum-cefoparazone, amikacin, pepircillin-tazobactum. A total of 220 samples of wide range were selected, i.e., blood, urine, pus, sputum, etc. and were analyzed using various techniques of Gram staining and biochemical identification. Results: After performing antibiotic sensitivity tests, 83% samples came out to be ESBL positive and 17% were ESBL negative. Conclusion: It was concluded that to ensure adequate treatment of infections arising especially from urinary pathogens and controlling spread of bacterial resistant strains, the continuous monitoring by bacterial susceptibility testing is essential

Stability analysis and dynamics of solitary wave solutions of the (3+1)-dimensional generalized shallow water wave equation using the Ricatti equation mapping method

Our aim is to examine the dynamic characteristics of the (3+1)-dimensional generalized equation governing shallow water waves. When the horizontal extent of the fluid significantly surpasses the vertical dimension, the employment of shallow water equations becomes appropriate. By employing an inventive Ricatti equation mapping approach, we have obtained a range of solitary wave solutions in both explicit and generalized forms. Solitons are particularly useful in signal and energy transmission due to their ability to preserve their shape during propagation. By studying soliton solutions in nonlinear systems, we can gain valuable knowledge applicable to practical fields. To deepen our grasp of the equation’s physical implications, we have presented some solutions through 3D, 2D, and contour graphics. Employing a linear stability approach, we confirm the equation’s stability. The method used distinguishes out for its simplicity, dependability, and ability to generate novel solutions for nonlinear partial differential equations in the area of mathematical physics. The research findings reported here demonstrate the viability of the used method in studying nonlinear phenomena in the studied equation as well as other nonlinear problems in mathematical physics. By employing this tool, academics have the chance to deepen and increase their grasp of the complex mathematical concepts underlying real-world problems

Non classical interaction aspects to a nonlinear physical model

This study deals the dynamics of waves to the conformable fractional (2+1)-dimensional Nizhnik–Novikov–Veselov (NNV) equations. The (2+1)-dimensional NNV equations are the isotropic Lax integrable extension of the (1+1)-dimensional Korteweg–de Vries equations. Fractional differential models (FDMs) from the corresponding integer order model can describes more complex behavior and even cover all properties of integer order model. By the usage of different test approaches, the Hirota bilinear method (HBM) has been successfully applied. The Hirota method is a well-known and reliable mathematical tool for finding the soliton solutions of fractional nonlinear partial differential equations in many fields. However, it demands bilinearization of nonlinear fractional PDE. A class of results in the shapes of lump-periodic, breather-type and two wave solutions have been extracted. Numerical visualizations of the results are also used to demonstrate the implications of the fractionality and parameters. It is acceptable to assume that many experts in engineering models will learn from this research. The results prove the used algorithm is effective, quick, easy, and flexible in its application to various systems