O(100GeV)\mathscr{O}(100 GeV) Deci-weak W′/Z′W^\prime/Z^\prime at Tevatron and LHC

Recently Tevatron released their measurements on invariant mass spectrum of electron/positron, as well as the di-jet arising from WW+WZ production with one W leptonically decay. Though the statistics is not significant, there are two bumps around 240 GeV and 120-160 GeV respectively. We proposed that the two bumps correspond to the extra light gauge bosons $Z^\prime$ and $W^\prime$, which couple with quarks with the deci-weak strength. In this brief report, we also simulated di-jet invariant mass distribution at the current running LHC.Comment: 8 pages, 3 EPS figures, ref added, figures update

New Color-Octet Vector Boson Revisit

Motivated by CDF recent measurements on di-jet invariant mass spectrum where di-jet is associated production with charged leptons ($e/\mu$) and missing energy, we re-examine the previous proposed massive color-octet axial-vector-like boson $Z_c$. Our simulation showed that the di-jet bump around 120-160 GeV can be induced by $Z_c$ with effective coupling $g_{Z_c q \bar q} =0.2 g_s$ (q represents the quark other than top and $g_s$ is the strong coupling constant). Moreover our numerical investigation indicated that the top quark forward-backward asymmetry $A_{FB}^t$ can be reproduced without distorting shape of differential cross section $d\sigma/d M_{t\bar t}$, provided that the $Z_c$ and top quark coupling is appropriately chosen ($g_{Z_c t \bar t} \simeq 4.5 g_{Z_c q \bar q}$). Our results also showed that the theoretical $A_{FB}^t$ as functions of $\Delta y$ and $M_{t\bar t}$ can be consistent with data within $1\sigma$ and $1.8\sigma$ respectively.Comment: 8 pages, 3 EPS figure

固本益肺汤联合腹针治疗尘肺30例疗效观察

Objective: To observe the clinical effect of Guben Yifei decoction combined with acupoint sticking therapy on pneumoconiosis. Methods: 60 cases of pneumoconiosis with syndrome of deficiency of both lung and kidney were randomly divided into two groups. The two groups were treated with oxygen, anti fibrosis, antiasthmatic, expectorant, and so on for 15 days of a course. In addition to the treatment program of control group, the patients in treatment group were also treated with Guben Yifei decoction (1 doses /d, water decoction) combined with abdominal acupuncture therapy, 1 times /d, for two courses. Observation of patients with cough, sputum, asthma, pulmonary rales and other effects was made and paid attention to symptoms and signs, serum immunoglobulin and changes of blood oxygen saturation before and after the treatment. Results: symptoms, signs disappeared time and healing time, oxygen saturation, serum immunoglobulin were better than the control group (P < 0.05), there was significant difference (P < 0.05). Conclusions: The curative effect of Guben Yifei decoction combined with abdominal acupuncture therapy on pneumoconiosis is remarkable.目的  观察固本益肺汤联合穴位贴敷治疗尘肺的临床疗效。方法  将60例辨证为肺肾两虚型尘肺的患者随机分为两组，两组均予以吸氧，抗纤维化，平喘，化痰等治疗。两组均以15天为1个疗程。治疗组在对照组治疗方案基础上加固本益肺汤治疗，1剂/d，水煎服，同时联合腹针疗法，1次/d，连续治疗两个疗程。观察患者咳嗽、咳痰、喘憋、肺部罗音等疗效，同时观察治疗前后症状、体征、血氧饱和度、血清免疫球蛋白等变化情况。结果  治疗组在症状、体征消失时间及治愈时间、血氧饱和度、血清免疫球蛋白等方面均优于对照组（P＜0.05），两组疗效比较，有显著性差异（P＜0.05）。结果  固本益肺汤联合腹针疗法治疗尘肺疗效显著

Effects of matrine on collagen proliferation and TNF-α, TGF-β1 and CTGF in atrial tissues of dogs with persistent atrial fibrillation

目的 探讨苦参碱对犬心房颤动（房颤）心房肌组织中胶原合成以及肿瘤坏死因子（tumor necrosis factor alpha,TNF-α）、转化生长因子（transforming growth factor-β1，TGF-β1）和结缔组织生长因子（connective Tissue Growth Factor，CTGF）表达变化的影响。方法 健康比格犬10只采用快速右心室起搏造房颤模型，随机分成房颤组和房颤+苦参碱组各5只。采用天狼星红染色，计算胶原容积分数（collagen volume fraction，CVF）以测定纤维化程度；采用免疫组织化学法检测右心房TNF-α、TGF-β1和CTGF的蛋白表达情况；用逆转录-聚合酶链反应（RT-PCR）技术检测TNF-α、TGF-β1和CTGF的mRNA水平表达情况。结果 与房颤组相比，房颤+苦参碱组纤维化程度降低，CVF明显下降（P＜0.05），TNF-α、TGF-β1和CTGF蛋白表达水平下降，且TNF-α和TGF-β1的mRNA表达水平显著下降（P＜0.05，P＜0.01）。结论 苦参碱可能通过抑制TNF-α、TGF-β1和CTGF的表达，抑制房颤心房肌胶原合成，改善心房组织纤维化程度。Objective:To study the effects of matrine (mat) on collagen synthesis and expression of tumor necrosis factoralpha (TNF-α), and transforming growth factor-β1 (TGF-β1) and connective tissue growth factor (CTGF) in atrial tissues of dogs with persistent atrial fibrillation (AF). Methods : Ten healthy beagle dogs were randomly divided into two groups: AF group (n=5) and AF/Mat group (n=5), using right ventricular pacing to establish AF model. The collagen volume fraction (CVF) in atrial tissue were detected by sirius red staining to determine the level of fabrication. The level of TNF-α, TGF-β1 and CTGF were detected by immunohisto-chemistry. The mRNA expression level of TNF-α, TGF-β1 and CTGF were detected by reverse transcription-polymerase chain reaction (RT-PCR). Results:  Compared with the AF group, the fabriation level of AF/Mat was decreased obviously (P<0.05), the expression levels of TNF-α, TGF-β1 and CTGF were decreased, and the mRNA expression level were decreased significantly in atrial tissues (P<0.05 and P<0.01). Conclusion: Matrine may inhibits fabrosis in atrial tissues through inhibition collagen proliferation and expression of TNF-α, TGF-β1 and CTGF

Synergistic Anti-MRSA Activity of Cationic Nanostructured Lipid Carriers in Combination With Oxacillin for Cutaneous Application

Nanoparticles have become a focus of interest due to their ability as antibacterial agents. The aim of this study was to evaluate the anti-methicillin-resistant Staphylococcus aureus (MRSA) activity of cationic nanostructured lipid carriers (NLC) combined with oxacillin against ATCC 33591 and clinical isolate. The cationic resource on the NLC surface was soyaethyl morpholinium ethosulfate (SME). NLC loaded with oxacillin was produced to assess the antibacterial activity and the effectiveness of topical application for treating cutaneous infection. The hydrodynamic diameter and zeta potential of oxacillin-loaded NLC were 177 nm and 19 mV, respectively. When combined with NLC, oxacillin exhibited synergistic MRSA eradication. After NLC encapsulation, the minimum bactericidal concentration (MBC) of oxacillin decreased from 250 to 62.5 μg/ml. The combined NLC and oxacillin reduced the MRSA biofilm thickness from 31.2 to 13.0 μm, which was lower than the effect of NLC (18.2 μm) and antibiotic (25.2 μm) alone. The oxacillin-loaded NLC showed significant reduction in the burden of intracellular MRSA in differentiated THP-1 cells. This reduction was greater than that achieved with individual treatment. The mechanistic study demonstrated the ability of cationic NLC to disrupt the bacterial membrane, leading to protein leakage. The cell surface disintegration also increased oxacillin delivery into the cytoplasm, activating the bactericidal process. Topical NLC treatment of MRSA abscess in the skin decreased the bacterial load by log 4 and improved the skin’s architecture and barrier function. Our results demonstrated that a combination of nanocarriers and an antibiotic could synergistically inhibit MRSA growth

Permutation-invariant Feature Restructuring for Correlation-aware Image Set-based Recognition

We consider the problem of comparing the similarity of image sets with variable-quantity, quality and un-ordered heterogeneous images. We use feature restructuring to exploit the correlations of both inner$\&$inter-set images. Specifically, the residual self-attention can effectively restructure the features using the other features within a set to emphasize the discriminative images and eliminate the redundancy. Then, a sparse/collaborative learning-based dependency-guided representation scheme reconstructs the probe features conditional to the gallery features in order to adaptively align the two sets. This enables our framework to be compatible with both verification and open-set identification. We show that the parametric self-attention network and non-parametric dictionary learning can be trained end-to-end by a unified alternative optimization scheme, and that the full framework is permutation-invariant. In the numerical experiments we conducted, our method achieves top performance on competitive image set/video-based face recognition and person re-identification benchmarks.Comment: Accepted to ICCV 201

Protective effect of human serum amyloid P on CCl4-induced acute liver injury in mice.

Human serum amyloid P (hSAP), a member of the pentraxin family, inhibits the activation of fibrocytes in culture and inhibits experimental renal, lung, skin and cardiac fibrosis. As hepatic inflammation is one of the causes of liver fibrosis, in the present study, we investigated the hepatoprotective effects of hSAP against carbon tetrachloride (CCl4)-induced liver injury. Our data indicated that hSAP attenuated hepatic histopathological abnormalities and significantly decreased inflammatory cell infiltration and pro-inflammatory factor expression. Moreover, CCl4-induced apoptosis in the mouse liver was inhibited by hSAP, as measured by terminal-deoxynucleotidyl transferase mediated nick-end labeling (TUNEL) assay and cleaved caspase-3 expression. hSAP significantly restored the expression of B cell lymphoma/leukemia (Bcl)-2 and suppressed the expression of Bcl-2-associated X protein (Bax) in vivo. The number of hepatocytes in early apoptosis stained with Annexin V was significantly reduced by 28-30% in the hSAP treatment group compared with the CCl4 group, and the expression of Bcl-2 was increased, whereas the expression of Bax and cleaved caspase-3 were significantly inhibited in the hSAP pre-treatment group compared with the CCl4 group. hSAP administration also inhibited the migration and activation of hepatic stellate cells (HSCs) in CCl4-injured liver and suppressed the activation of isolated primary HSCs induced by transforming growth factor (TGF)-β1 in vitro. Collectively, these findings suggest that hSAP exerts a protective effect againts CCl4-induced hepatic injury by suppressing the inflammatory response and hepatocyte apoptosis, potentially by inhibiting HSC activation

Expression of the Androgen Receptor and its Correlation with Molecular Subtypes in 980 Chinese Breast Cancer Patients

Background Recent studies have shown that androgen displays an inhibitory effect on breast cancer cell lines that express androgen receptor (AR) but not estrogen receptor (ER) and progesterone receptor (PR). We have previously reported that approximately 1/3 of ER negative high grade invasive ductal carcinomas express AR. Thus, AR can serve as a potential therapeutic target for this group of patients. Aim Here we investigated AR expression patterns in 980 consecutive breast carcinomas. Results We found that (1) AR was expressed more frequently (77%) than ER (61%) and PR (60%) in breast carcinomas; (2) AR expression was associated with ER and PR expression ( P < 0.0001), small tumor size ( P = 0.0324) and lower Ki-67 expression ( P = 0.0013); (3) AR expression was found in 65% of ER negative tumors; (4) AR expression was associated with PR and Ki-67 in ER negative tumors, but not in ER positive tumors; (5) AR expression was higher in ER positive subtypes (Luminal A, Luminal B and Luminal HER2 subtypes, 80%-86%) and lower in ER negative subtypes [HER2, triple negative (TN), and TN EFGR positive subtypes; 52%-66%], with over 50% of TN tumors expressing AR. Conclusion More breast carcinomas express AR than ER and PR, including significant numbers of ER negative and TN tumors, for which AR could serve as a potential therapeutic target

Calorie restriction and endurance exercise share potent anti-inflammatory function in adipose tissues in ameliorating diet-induced obesity and insulin resistance in mice

<p>Abstract</p> <p>Background</p> <p>Calorie restriction (CR) and endurance exercise are known to attenuate obesity and improve the metabolic syndrome. The aim of this study was to directly compare the effects of CR and endurance exercise in a mouse model of diet-induced obesity and insulin resistance.</p> <p>Methods</p> <p>Adult male C57BL/6N mice were randomly assigned and subjected to one of the six interventions for 8 weeks: low-fat diet (LC, 10% fat), low-fat diet with 30% calorie restriction (LR), high-fat diet (HC, 60% fat), high-fat diet with 30% calorie restriction (HR), high-fat diet with voluntary running exercise (HE), and high-fat diet with a combination of 30% calorie restriction and exercise (HRE). The impacts of the interventions were assessed by comprehensive metabolic analyses and pro-inflammatory cytokine gene expression.</p> <p>Results</p> <p>Endurance exercise significantly attenuated high-fat diet-induced obesity. CR dramatically prevented high-fat diet-induced metabolic abnormalities. A combination of CR and endurance exercise further reduced obesity and insulin resistance under the condition of high-fat diet. CR and endurance exercise each potently suppressed the expression of inflammatory cytokines in white adipose tissues with additive effects when combined, but the effects of diet and exercise interventions in the liver were moderate to minimal.</p> <p>Conclusions</p> <p>CR and endurance exercise share a potent anti-inflammatory function in adipose tissues in ameliorating diet-induced obesity and insulin resistance.</p