Risk Factors for Bleeding After Endoscopic Submucosal Dissection for Gastric Cancer in Elderly Patients Older Than 80 Years in Japan.

Introduction:As the aging of people in a society advances, the number of elderly patients older than 80 years in Japan with gastric cancer continues to increase. Although delayed ulcer bleeding is a major adverse event after endoscopic submucosal dissection (ESD), little is known about characteristic risk factors for bleeding in elderly patients undergoing ESD. This study aimed to evaluate risk factors for delayed bleeding after ESD for gastric cancer in elderly patients older than 80 years.Methods:We retrospectively evaluated the incidence of delayed bleeding after ESD in 10,320 patients with early-stage gastric cancer resected by ESD between November 2013 and January 2016 at 33 Japanese institutions and investigated risk factors for delayed bleeding in elderly patients older than 80 years.Results:The incidence of delayed bleeding in elderly patients older than 80 years was 5.7% (95% confidence interval [CI]: 4.6%-6.9%, 95/1,675), which was significantly higher than that in nonelderly (older than 20 years and younger than 80 years) patients (4.5%, 4.1%-5.0%, 393/8,645). Predictive factors for ESD-associated bleeding differed between nonelderly and elderly patients. On multivariate analysis of predictive factors at the time of treatment, risk factors in elderly patients were hemodialysis (odds ratio: 4.591, 95% CI: 2.056-10.248, P < 0.001) and warfarin use (odds ratio: 4.783, 95% CI: 1.689-13.540, P = 0.003).Discussion:This multicenter study found that the incidence of delayed bleeding after ESD in Japanese patients older than 80 years was high, especially in patients receiving hemodialysis and taking warfarin. Management of ESD to prevent delayed bleeding requires particular care in patients older than 80 years

Idiopathic Adult Intussusception : A Case Report

Adult intussusceptions account for 5-10％ of all intussusception cases and are considered rare, whereas they are most commonly encountered in children. Among adult cases, idiopathic intussusceptions are pretty rare. A 36-year-old male was admitted to our hospital with abdominal pain. His body temperature was 37.0℃, the white blood cell count was 14,000/μl and CRP 0.01mg/dl. A standing abdominal X-ray showed slight niveau formation. Computed tomography demonstrated the multiple concentric ring sign. His condition detoriorated and a laparotomy was performed. Intraoperatlvely,a mass measuring six centimeters in diameter was seen in the left side of the hepatic flexure of the transverse colon. The diseased intestine was reducted with Hutchinson’s maneuver. No lesions or malignancy were found, however an ileocecal resection was performed to prevent recurrence of the intussusception. The resected specimen showed congestion and wall thickening. Pathological examination of resected specimen showed marked congestion and hemorrhage with coagulation necrosis. The patient’s postoperative course was uneventful and he was discharged from our hospital on the 10th postoperative day. After nineteen months’follow up,no recurrence of the intussusception has been seen. Reduction of the bowel followed by minimum bowel resection should be considered to prevent recurrence of the intussusception and to avoid short gut or adhesional ileus

Malignant Lymphoma of the Ileum Treated by Laparoscopically Assisted Bowel Resection : A Case Report

Primary malignant lymphoma of the small intestine is uncommon. We herein present a case of malignant lymphoma of the ileum, which was treated by laparoscopically assisted surgery. A 60-yearold male with lower abdominal pain and vomiting was admitted to our hospital. A standing abdominal X-ray showed niveau formation. Computed tomography demonstrated circumferential wall thickening in the terminal ileum. Laparoscopically assisted surgery was performed under a diagnosis of tumor of the ileum. Under laparoscopic exploration, tumor of the ileum was detected. Partial resection of the ileum and dissection of lymph nodes were performed extracorporeally. Histological findings demonstrated diffuse large atypical lymphocytes with vesicle-like chromatin and clear nucleolus. Immunologically, CD20 and CD79a were positive. These findings were compatible with those of diffuse large B-cell lymphoma. Paraintestinal lymph nodes were also involved. The postoperative course was uneventful. Neither gallium scintigraphy nor FDG-PET showed any scintillation. The patient was given R-CHOP therapy and is currently doing well with no sign of recurrence. In conclusion, we propose that laparoscopic surgery for malignant lymphoma of the small intestine is a feasible and promising therapeutic option, especially in a case demonstrating bowel obstruction, because this procedure is thought to be minimally invasive,allows quick postoperative recovery and shortened hospital stay could be expected