看護基礎教育におけるキャリア支援と評価

島根県立大学短期大学部・出雲キャンパスでは統合・法人化した平成19年度に、キャリアセンターが組織的に位置づけられた。それを機に今まで行なっていた就職支援等を、キャリア支援プログラムとして整理し、大学行事として企画・運営している。今回は、出雲キャンパス・キャリアセンターとして入学から卒業までを支援した看護学科の学生80名を対象に、毎回の進路セミナー終了時と進路が決定した卒業時の学生評価を比較した。その結果から、キャリア開発プログラム等について意義や効果が明らかになったので報告する

Crude α-Mangostin Suppresses the Development of Atherosclerotic Lesions in <i>Apoe</i>-Deficient Mice by a Possible M2 Macrophage-Mediated Mechanism

Lifestyle choices play a significant role in the etiology of atherosclerosis. Male Apoe&#8722;/&#8722; mice that develop spontaneous atherosclerotic lesions were fed 0%, 0.3%, and 0.4% mangosteen extracts, composed largely of &#945;-mangostin (MG), for 17 weeks. Body weight gains were significantly decreased in both MG-treated groups compared to the control, but the general condition remained good throughout the study. The levels of total cholesterol (decreased very-low-density lipoprotein in lipoprotein profile) and triglycerides decreased significantly in the MG-treated mice in conjunction with decreased hepatic HMG-CoA synthase and Fatty acid transporter. Additionally, increased serum lipoprotein lipase activity and histopathology further showed a significant reduction in atherosclerotic lesions at both levels of MG exposure. Real-time PCR analysis for macrophage indicators showed a significant elevation in the levels of Cd163, an M2 macrophage marker, in the lesions of mice receiving 0.4% MG. However, the levels of Nos2, associated with M1 macrophages, showed no change. In addition, quantitative immunohistochemical analysis of macrophage subtypes showed a tendency for increased M2 populations (CD68+/CD163+) in the lesions of mice given 0.4% MG. In further analysis of the cytokine-polarizing macrophage subtypes, the levels of Interleukin13 (Il13), associated with M2 polarization, were significantly elevated in lesions exposed to 0.4% MG. Thus, MG could suppress the development of atherosclerosis in Apoe&#8722;/&#8722; mice, possibly through an M2 macrophage-mediated mechanism