Redshift Dependent Lag-Luminosity Relation in 565 BASTE Gamma Ray Bursts

We compared redshifts $z_Y$ from Yonetoku relation and $z_{lag}$ from the lag-luminosity relation for 565 BASTE GRBs and were surprised to find that the correlation is very low. Assuming that the luminosity is a function of both $z_Y$ and the intrinsic spectral lag $\tau_{lag}$, we found a new redshift dependent lag-luminosity relation as $L=7.5\times 10^{50}{\rm erg/s}(1+z)^{2.53}\tau_{lag}^{-0.282}$ with the correlation coefficient of 0.77 and the chance probability of $7.9\times 10^{-75}$. To check the validity of this method, we examined the other luminosity indicator, Amati relation, using $z_Y$ and the observed fluence and found the correlation coefficient of 0.92 and the chance probability of $5.2\times 10^{-106}$. Although the spectral lag is computed from two channels of BATSE, our new lag-luminosity relation suggests that a possible lag-luminosity relation in the \swift era should also depend on redshift

Constraints on w0w_0 and waw_a of Dark Energy from High Redshift Gamma Ray Bursts

We extend the Hubble diagram up to $z = 5.6$ using 63 gamma-ray bursts (GRBs) via peak energy-peak luminosity relation (so called Yonetoku relation), and obtain constraints on cosmological parameters including dynamical dark energy parametrized by $P/\rho\equiv w(z) = w_0 + w_a \cdot z/(1+z)$. It is found that the current GRB data are consistent with the concordance model, ($\Omega_m = 0.28, \Omega_{\Lambda} = 0.72, w_0 = -1, w_a = 0$), within two sigma level. Although constraints from GRBs themselves are not so strong, they can improve the conventional constraints from SNeIa because GRBs have much higher redshifts. Further we estimate the constraints on the dark-energy parameters expected by future observations with GLAST (Gamma-ray Large Area Space Telescope) and \swift by Monte-Carlo simulation. Constraints would improve substantially with another 150 GRBs.Comment: 5 pages, 6 figures. Submitted tu MNRA

Changes in Plasma Clozapine Levels after Smoking Cessation in Japanese Inpatients with Schizophrenia: A Retrospective Cohort Study

Although reported for Caucasians, changes in plasma clozapine levels after smoking cessation in East Asians remain unclear. We here investigated plasma clozapine levels before and after smoking cessation in Japanese inpatients with schizophrenia. We conducted a retrospective chart review of 14 inpatients with schizophrenia who were being treated with clozapine between June 1, 2019, and July 31, 2019 and who were smokers as of July 1, 2019, the day on which a smoking ban was instituted in the tertiary public psychiatric hospital. The primary outcome was individual differences in plasma clozapine levels between before and after the smoking ban, which were compared using paired t-tests. The mean plasma clozapine level was significantly increased, by 213.4 ng/mL (95% CI 119.9-306.8; p<0.01) or 53.2%. Four of the 14 inpatients experienced clinically significant side effects, such as myoclonus, drooling, and amnesia, due to the development of high plasma clozapine levels. Our findings indicated that close monitoring of plasma clozapine levels before and after smoking cessation and prior dose adjustment of clozapine may be necessary, to prevent a significant risk of developing high plasma clozapine levels, even in Japanese patients

Steep medial tibial slope and prolonged delay to surgery are associated with bilateral medial meniscus posterior root tear

Purpose Contralateral medial meniscus posterior root tear (MMPRT) can sometimes occur after primary surgeries for MMPRT and lead to unsatisfactory outcomes. The incidence rate and risk factors for contralateral MMPRT have not been well investigated, despite their clinical importance. Therefore, the incidence and predictors of bilateral MMPRT were aimed to be evaluated. Methods Fourteen patients with bilateral MMPRT (group B) and 169 patients with unilateral MMPRT (group U) were enrolled in this study. Sex, age, body mass index, time between injury and surgery, and medial tibial slope angle (MTSA) were compared between the groups. MTSA was measured using lateral radiographs. Results The incidence rate of bilateral MMPRT was 6.2% among all patients with MMPRTs. Multivariate logistic regression analysis showed that a prolonged time between injury and surgery (odds ratio [OR], 1.0; 95% confidence interval [CI] 1.00–1.01; P  10.0° was associated with bilateral MMPRT, with a sensitivity of 93% and specificity of 69%. Conclusion A longer time between injury and surgery and steeper MTSA were risk factors for the development of bilateral MMPRT. Surgeons need to pay close attention to the contralateral knee in addition to the primary injured knees when treating knees with steep MTSA. Besides, early meniscal repair of primary MMPRT would be important to prevent the events of contralateral MMPRT

High body mass index is a risk factor for unfavorable clinical outcomes after medial meniscus posterior root repair in well-aligned knees

BackgroundSevere chondral lesions and varus knee alignment are associated with poor outcomes following transtibial pullout repair for medial meniscus posterior root tears and meniscus tear is strongly associated with body mass index. The prognostic factors in well-aligned knees (femorotibial angle  MethodsWe retrospectively reviewed the files of 28 patients who had undergone pullout repair of medial meniscus posterior root tears between October 2016 and December 2017. We recorded the baseline characteristics (age, gender, height, weight, and body mass index) and the time between injury and surgery. We recorded the International Knee Documentation Committee scores, Knee injury and Osteoarthritis Outcome Scores, and pain visual analog scale scores. Using magnetic resonance imaging preoperatively and 1 year after surgery, we measured the medial meniscus body width and absolute and relative medial meniscus extrusion. Pearson correlation and multivariate linear regression analyses were used to assess potential associations between these factors and clinical outcomes. ResultsAge positively correlated (coefficient = 0.49, P  ConclusionsBody mass index > 30 kg/m(2) is a risk factor for unfavorable clinical outcomes following pullout repair of medial meniscus posterior root tears in well-aligned knees. Level of evidenceIII, Comparative retrospective study

An MRI-based suspension bridge sign can predict an arthroscopically favorable meniscal healing following the medial meniscus posterior root repair

Background Medial meniscus (MM) posterior root repairs show favorable clinical outcomes in patients with MM posterior root tears (MMPRTs). However, there is no useful magnetic resonance imaging (MRI) finding to determine a functionally good meniscal healing following MM posterior root repairs. We hypothesized that a characteristic postoperative MRI finding can predict a good meniscal healing following pullout repairs. The aim of this study was to investigate a clinical usefulness of several MRI findings for estimating an actual meniscal healing following MMPRT repairs. Methods Fifty eight patients who had a posteromedial painful popping of the injured knee and underwent an arthroscopic pullout repair for the MMPRT were included. Arthroscopic meniscal healing was assessed according to the Furumatsu scoring system at 1 year postoperatively. We evaluated postoperative MRI-based meniscal healing using signal intensity, continuity, suspension bridge-like sign of the MM posterior root, and MM medial extrusion on coronal images. Postoperative clinical outcome evaluations were performed at second-look arthroscopy. Results Twenty three patients showed good arthroscopic healing scores (≥7 points). Thirty five patients had moderate/poor arthroscopic healing scores ( Conclusions Our study demonstrated that the MRI-based suspension bridge sign can predict an arthroscopically favorable meniscal healing following the MM posterior root repair. The suspension bridge-like MRI finding of the MM would be a useful indicator to evaluate the actual meniscal healing in patients who underwent pullout repairs for MMPRTs

Transtibial pullout repair of the lateral meniscus posterior root tear combined with anterior cruciate ligament reconstruction reduces lateral meniscus extrusion: A retrospective study

Background Lateral meniscus (LM) posterior root tear (PRT) is often associated with anterior cruciate ligament (ACL) injury and can result in rotational instability, joint overloading, and degenerative changes in the knee. Improved rotational stability and kinematics have been reported after LMPRT repair. However, it is unclear what repair technique can achieve the greatest reduction in LM extrusion (LME). Hypothesis We hypothesized that transtibial pullout repair would decrease LME to a greater extent than other repair techniques. Patients and methods Seventeen patients with ACL injury and complete LMPRT were evaluated. Nine underwent ACL reconstruction (ACLR) and transtibial pullout repair, and eight underwent ACLR and other repairs such as inside-out suturing. Double-bundle ACLR was performed using hamstring tendons, and LMPRT pullout repair was performed through the bone tunnel for the posterolateral bundle. Magnetic resonance imaging was performed immediately preoperatively and at > 6 months postoperatively, and LME was measured from coronal images only. Results A significantly greater decrease in the value of LME from pre- to postoperative measurement was observed in the transtibial pullout repair group (−0.5 ± 0.7 mm) than in the other-repair group (1.0 ± 0.9 mm, p Discussion The most important finding of this study was that transtibial pullout repair resulted in a greater decrease in LME than other repair techniques in patients with ACL injury and LMPRT. This technique might be useful for restoring hoop tension by decreasing LME

The distance between the tibial tunnel aperture and meniscal root attachment is correlated with meniscal healing status following transtibial pullout repair for medial meniscus posterior root tear

Background To investigate the relationship between tibial tunnel aperture location and postoperative meniscal healing. Methods We enrolled 25 patients (20 women and five men, mean age: 62.5 years) who underwent transtibial pullout repair for medial meniscus (MM) posterior root repair. The expected MM posterior root attachment center (AC) and tibial tunnel center (TC) were identified using three-dimensional computed tomography, and the minimum AC–TC distance was calculated. The meniscal healing status following transtibial pullout repair was assessed by second-look arthroscopy (mean postoperative period: 15 months) using a previously reported scoring system (meniscal healing score; range: 0–10). The association between AC–TC distance and meniscal healing score was investigated using univariate linear regression models. The optimal AC–TC distance cut-off for improved MM healing score (≥ 7) was determined using receiver operating characteristic analysis. Results The AC–TC distance and meniscal healing score were significantly associated (y = − 0.42x + 9.48, R2 = 0.342; P = 0.002), with the optimum AC–TC distance being 5.8 mm. This cut-off had a sensitivity of 100% and specificity of 53%. Conclusions This study demonstrates that AC–TC distance is significantly correlated with postoperative meniscal healing. Anatomical repair within 5.8 mm of the AC may result in improved meniscal healing

Gamma-Ray Bursts in 1.8<z<5.61.8 < z < 5.6 Suggest that the Time Variation of the Dark Energy is Small

We calibrated the peak energy-peak luminosity relation of GRBs (so called Yonetoku relation) using 33 events with the redshift $z < 1.62$ without assuming any cosmological models. The luminosity distances to GRBs are estimated from those of large amount of Type Ia supernovae with $z<1.755$. This calibrated Yonetoku relation can be used as a new cosmic distance ladder toward higher redshifts. We determined the luminosity distances of 30 GRBs in $1.8 < z < 5.6$ using the calibrated relation and plotted the likelihood contour in $(\Omega_m,\Omega_\Lambda)$ plane. We obtained $(\Omega_m, \Omega_{\Lambda})= (0.37^{+0.14}_{-0.11}, 0.63^{+0.11}_{-0.14})$ for a flat universe. Since our method is free from the circularity problem, we can say that our universe in $1.8 < z < 5.6$ is compatible with the so called concordance cosmological model derived for $z < 1.8$. This suggests that the time variation of the dark energy is small or zero up to $z\sim 6$.Comment: 4 pages, 4 figures, accepted to MNRA