ユング ニヨル パーソナリティ リロン サイコウ シゼン ノ ダイナミズム オ テガカリ トシテ

ユングのパーソナリティ理論はフロイトの精神分析理論に大いに触発されて発展した。意識と無意識に関するパーソナリティ理論として、タイプ論と個性化の理論は、心を自然の一部としてとらえる点にその独自性がみとめられる。ユングによれば、心の理論は生命にあふれた自然であり、心のダイナミズムは生命的要素に基づくものであった。本研究では、ユングのパーソナリティ理論や研究を、自然や生命論に由来するダイナミズムの観点からとらえることを試みる。そこで以下の二点が明らかになった。第一に彼のパーソナリティ理論において無意識の補償作用が重要な役割を果たしている。第二に、タイプ論と個性化理論は共に、個人がその人生において独自性を生きることを重要な目的としている。ユングのパーソナリティ理論においては、意識と無意識に関する理論、タイプ論、個性化理論が相互に関連しながら、自我中心主義を超越して、意識領域と無意識領域からなる本来の自分自身の実現に向かう動きを論じている理論体系である。C. G. Jung developed his personality theory, based on inspiration Freud’s Psychoanalysis. His personality theories on consciousness and unconsciousness, typology and individuation are unique in that he regarded mind as a part of nature. In Jung’s view, a model for the mind is living nature and the dynamism of mind is based on a biological factor. The aim of this research is to examine the personality theories of C. G. Jung in terms of nature and life science. At first his theories pay attention to the compensation function of the unconsciousness. Secondly, they have the same purpose which is to realize their own uniqueness as an individual from a biological view. Each of his theories, on consciousness and unconsciousness, typology and individuation are connected with each other and converge to transcendent ego-centrism, toward the realization of their own self which consists of a conscious mind and an unconscious realm.研究動

Intratumoral peptide injection enhances tumor cell antigenicity recognized by cytotoxic T lymphocytes: a potential option for improvement in antigen-specific cancer immunotherapy

Antigen-specific cancer immunotherapy is a promising strategy for improving cancer treatment. Recently, many tumor-associated antigens and their epitopes recognized by cytotoxic T lymphocytes (CTLs) have been identified. However, the density of endogenously presented antigen-derived peptides on tumor cells is generally sparse, resulting in the inability of antigen-specific CTLs to work effectively. We hypothesize that increasing the density of an antigen-derived peptide would enhance antigen-specific cancer immunotherapy. Here, we demonstrated that intratumoral peptide injection leads to additional peptide loading onto major histocompatibility complex class I molecules of tumor cells, enhancing tumor cell recognition by antigen-specific CTLs. In in vitro studies, human leukocyte antigen (HLA)-A*02:01-restricted glypican-3(144-152) (FVGEFFTDV) and cytomegalovirus(495-503) (NLVPMVATV) peptide-specific CTLs showed strong activity against all peptide-pulsed cell lines, regardless of whether the tumor cells expressed the antigen. In in vivo studies using immunodeficient mice, glypican-3(144-152) and cytomegalovirus(495-503) peptides injected into a solid mass were loaded onto HLA class I molecules of tumor cells. In a peptide vaccine model and an adoptive cell transfer model using C57BL/6 mice, intratumoral injection of ovalbumin(257-264) peptide (SIINFEKL) was effective for tumor growth inhibition and survival against ovalbumin-negative tumors without adverse reactions. Moreover, we demonstrated an antigen-spreading effect that occurred after intratumoral peptide injection. Intratumoral peptide injection enhances tumor cell antigenicity and may be a useful option for improvement in antigen-specific cancer immunotherapy against solid tumors

年齢に応じた血中活性型ビタミンD濃度, 腎Cyp27b1およびCyp24a1発現に対する食餌性リン反応性の変化には腎α-Klotho遺伝子発現が関連する

In this study, we investigated the relationship between age-related changes in renal α-Klotho gene expression, vitamin D metabolism and the responsiveness of dietary phosphate in 1, 2 and 13 month-old mice fed a high phosphate (phosphate 1.2%) diet or low phosphate (phosphate 0.02%) diet for 5 days. We found that 1,25-dihydroxyvitamin D levels in plasma were significantly lower in the high phosphate group than the low phosphate group for 1 and 2 month-old mice, but not 13 month-old mice. In addition, in the high phosphate group plasma 1,25-dihydroxyvitamin D levels were decreased in 2 month-old mice relative to 1 month-old mice, but 13 month-old mice had higher levels than 2 month-old mice. In fact, plasma 1,25-dihydroxyvitamin D levels showed a significant correlation with vitamin D metabolism gene Cyp27b1 and Cyp24a1 mRNA expression in the high phosphate group. Interestingly, renal α-Klotho mRNA and protein levels were significant change with age. Furthermore, α-Klotho mRNA expression showed a significant negative correlation with plasma 1,25-dihydroxyvitamin D levels in the high phosphate group. Our results suggest that age-related alterations in renal α-Klotho expression could affect the responsiveness of dietary phosphate to vitamin D metabolism

ステロール応答領域結合タンパク質1は腎近位尿細管細胞において25-水酸化ビタミンD3 24-水酸化酵素遺伝子の転写を活性化する

The physiological activity of the steroid derived hormone vitamin D is regulated by several enzymatic steps. Both 25-hydroxy vitamin D3 1a-hydroxylase (CYP27B1) and 25-hydroxyvitamin D3 24-hydroxylase (CYP24A1) modulate blood levels of 1,25-dihydroxyvitamin D3, an activated form of vitamin D. We previously demonstrated that CYP27B1 expression was trans-activated by sterol regulatory element binding protein 1 (SREBP1), although whether SREBP1 also regulates CYP24A1 transcription was unclear. Here we investigated the ability of SREBP1 to affect CYP24A1 transcription. In a luciferase reporter assay, mouse and human CYP24A1 promoter activity was strongly activated by SREBP1 in opossum kidney proximal tubular cells (OK-P). Three putative SREs (pSREs) were found in the mouse Cyp24a1 gene promoter and the SREBP1 protein showed specific binding to the pSRE1 element in EMSAs. Site-directed mutagenesis of the pSRE1 element strongly decreased SREBP1-mediated Cyp24a1 gene transcription. Moreover, siRNA-mediated SREBP1 knock-down repressed CYP24A1 expression in human renal proximal tubular epithelial cells (HKC-8). In animal studies, mice given various doses of thyroid hormone (T3) showed dose-dependent reductions in renal Srebp1c and Cyp24a1 mRNA levels. Taken together, our results suggest that SREBP1 trans-activates CYP24A1 expression through SREBP binding elements present in the promoter

From the Bloch sphere to phase space representations with the Gottesman-Kitaev-Preskill encoding

In this work, we study the Wigner phase-space representation of qubit states encoded in continuous variables (CV) by using the Gottesman-Kitaev-Preskill (GKP) mapping. We explore a possible connection between resources for universal quantum computation in discrete-variable (DV) systems, i.e. non-stabilizer states, and negativity of the Wigner function in CV architectures, which is a necessary requirement for quantum advantage. In particular, we show that the lowest Wigner logarithmic negativity of qubit states encoded in CV with the GKP mapping corresponds to encoded stabilizer states, while the maximum negativity is associated with the most non-stabilizer states, H-type and T-type quantum states.Comment: (v1) Accepted for publication in the Springer's "Mathematics for Industry" series. (v2) Typo in the abstract fixed; URL of the conference where the paper has been presented added: International Symposium on Mathematics, Quantum Theory, and Cryptography (MQC), held in September 2019 in Fukuoka, Japan (https://www.mqc2019.org/mqc2019/program

Os desafios urbano e ambientais da Microbacia do Lageado no Itaim Paulista

This article presents the urban environmental challenges of the Lageado stream Microbasin in Itaim Paulista, east of São Paulo. It is a highly urbanized area with medium and low standard buildings and precarious settlements in risky areas. Many flooding points are concentrated in the Microbasin's outflow. Based on the climate action policy of the city of São Paulo, we discuss the potential of hydrological modeling for a local action within the Lab Itaim Paulista Laboratory of Urban Policy and Local Planning at Universidade São Judas Tadeu.Este artículo presenta los desafíos ambientales urbanos de la microcuenca del arroyo Lageado en Itaim Paulista, al este de São Paulo. Es una zona muy urbanizada con edificaciones de nivel medio y bajo y asentamientos precarios en zonas de riesgo. Muchos puntos de inundación se concentran en el desagüe de la microcuenca. A partir de la política de acción climática de la ciudad de São Paulo, discutimos el potencial de la modelización hidrológica para una acción local dentro del Laboratorio Itaim Paulista de Política Urbana y Planificación Local de la Universidade São Judas Tadeu.Este artigo apresenta os desafios urbano ambientais da Microbacia do ribeirão do Lageado no Itaim Paulista zona leste de São Paulo. Trata-se de uma área altamente urbanizada com edificações de padrão médio e baixo e assentamentos precários em áreas de risco. No exutório da Microbacia concentra-se muitos pontos de alagamento. Com base na política de ação climática da cidade de São Paulo discutimos as potencialidades da modelagem hidrológica para uma ação local no âmbito das atividades do Lab Itaim Paulista Laboratório de Política Urbana e Planejamento Local da Universidade São Judas Tadeu