A Proposal of Color Image Processing Applications for Education

There are two main problems in the present style of education in which there are one teacher and many students in a class. The first problem is to improve communication between one teacher and many students in classes. The second problem is to realize personal education using IT systems. To solve the above two problems, we propose color image processing applications for education in this chapter. To improve communication between one teacher and many students, we realized automatic response analyzer that counts automatically students’ answers using color cards raised by students. The system is an easy-to-use simple system, which only consists of a PC, web cameras, and color cards. The recognition rate was 98% in brighter class and 93% in darker class. To realize automatic personal education, we realized two interactive IT systems using color image recognition. First, we realized color learning system with color analysis functions. Using the system, students can learn color distribution in 3D color space for their selected images. Second, we realized visual programming system that judges automatically the correctness of the graphical image output by student program. If the student’s output image is not correct, the system can point out the wrong part in the output image

Stimulation of nuclear receptor REV-ERBs suppresses production of pronociceptive molecules in cultured spinal astrocytes and ameliorates mechanical hypersensitivity of inflammatory and neuropathic pain of mice

The orphan nuclear receptors REV-ERBα and REV-ERBβ (REV-ERBs) are crucial in the regulation of inflammatory-related gene transcription in astroglioma cells, but their role in nociceptive transduction has yet to be elaborated. Spinal dorsal horn astrocytes contribute to the maintenance of chronic pain. Treatment of cultured spinal astrocytes with specific REV-ERBs agonists SR9009 or GSK4112 significantly prevented lipopolysaccharide (LPS)-induced mRNA upregulation of pronociceptive molecules interleukin-1β (IL-1β) mRNA, interleukin-6 (IL-6) mRNA and matrix metalloprotease-9 (MMP-9) mRNA, but not CCL2 mRNA expression. Treatment with SR9009 also blocked tumor necrosis factor-induced IL-1β mRNA, IL-6 mRNA and MMP-9 mRNA. In addition, treatment with SR9009 significantly blocked LPS-induced upregulation of IL-1β protein, IL-6 protein and MMP-9 activity. The inhibitory effects of SR9009 on LPS-induced expression of pronociceptive molecules were blocked by knockdown of REV-ERBs expression with short interference RNA, confirming that SR9009 exerts its effect through REV-ERBs. Intrathecal LPS treatment in male mice induces hind paw mechanical hypersensitivity, and upregulation of IL-1β mRNA, IL-6 mRNA and glial fibrillary acidic protein (GFAP) expression in spinal dorsal horn. Intrathecal pretreatment of SR9009 prevented the onset of LPS-induced mechanical hypersensitivity, cytokine expression and GFAP expression. Intrathecal injection of SR9009 also ameliorated mechanical hypersensitivity during the maintenance phase of complete Freund’s adjuvant-induced inflammatory pain and partial sciatic nerve ligation-, paclitaxel-, and streptozotocin-induced neuropathy in mice. The current findings suggest that spinal astrocytic REV-ERBs could be critical in the regulation of nociceptive transduction through downregulation of pronociceptive molecule expression. Thus, spinal REV-ERBs could be an effective therapeutic target in the treatment of chronic pain.This work was supported by Grant-in-Aid for Scientific Research (C) grant number 26460342, and grants from the Takeda Science Foundation, Suzuken Memorial Foundation, The Uehara Memorial Foundation and The Nakatomi Foundation. Experiments were carried out using equipment at the Analysis Center of Life Science, Hiroshima University and the Research Center for Molecular Medicine, Faculty of Medicine, Hiroshima University

Sunyaev-Zel'dovich power spectrum with decaying cold dark matter

Recent studies of structures of galaxies and clusters imply that dark matter might be unstable and decay with lifetime $\Gamma^{-1}$ about the age of universe. We study the effects of the decay of cold dark matter on the Sunyaev-Zel'dovich (SZ) power spectrum. We analytically calculate the SZ power spectrum taking finite lifetime of cold dark matter into account. We find the finite lifetime of dark matter decreases the power at large scale ($l < 4000$) and increases at small scale ($l > 4000$). This is in marked contrast with the dependence of other cosmological parameters such as the amplitude of mass fluctuations $\sigma_{8}$ and the cosmological constant $\Omega_{\lambda}$ (under the assumption of a flat universe) which mainly change the normalization of the angular power spectrum. This difference allows one to determine the lifetime and other cosmological parameters rather separately. We also investigate sensitivity of a future SZ survey to the cosmological parameters including the life time, assuming a fiducial model $\Gamma^{-1} = 10 h^{-1} {\rm Gyr}$, $\sigma_{8} = 1.0$, and $\Omega_{\lambda} = 0.7$. We show that future SZ surveys such as ACT, AMIBA, and BOLOCAM can determine the lifetime within factor of two even if $\sigma_{8}$ and $\Omega_{\lambda}$ are marginalized.Comment: 7 pages, 5 figure

Controlling negative and positive photothermal migration of centimeter-sized droplets

The photoinduced motion of an oil droplet on an aqueous solution under local irradiation by a green laser is reported. The results showed that a repulsive force is generated on pure water, while an attractive force is observed with an aqueous solution containing a surfactant. The driving force is discussed in terms of a thermal Marangoni effect. The switching on the photothermal effect is interpreted by taking into account the advection caused by the spatial gradient of the surface tension under local heating by a laser. A numerical model revealed that the geometrical profile of the surface tension around the droplet determines the mode of advection around the droplet and causes switching in the direction of migrations

Surgical Resection and Pazopanib Treatment for Recurrent Cardiac Angiosarcoma

Cardiac sarcoma treatment is challenging for surgeons because of frequent tumor recurrence and poor prognosis. In addition, optimal management of recurrences is not well established. The multi-targeted tyrosine kinase inhibitor, pazopanib, was recently approved for soft-tissue sarcoma. Herein, we present a case involving recurrent cardiac angiosarcoma where the patient survived for 2 years with complete remission of disease after repeated surgical resection and treatment with oral pazopanib. Based on our experience, aggressive surgical resection combined with pazopanib may be a valid treatment for recurrent cardiac angiosarcoma to improve patient survival

Long-term outcome of a dilated cardiomyopathy patient after mitral valve surgery combined with tissue-engineered myoblast sheets—report of a case

Abstract Background Dilated cardiomyopathy (DCM) is a life-threatening heart muscle disease characterized by progressive heart failure, which often requires left ventricular assist device (LVAD) implantation or heart transplantation (HTx). A tissue engineering strategy using cell sheets for end-stage heart failure has emerged in recent years. Case presentation Here, we describe a 50-year-old DCM patient with severe symptoms of heart failure with severe mitral regurgitation (MR) who was not a candidate for LVAD or HTx. The patient underwent mitral valve replacement followed by the transplantation of autologous myoblast sheets. Conclusion The patient’s clinical symptoms improved with a preservation of cardiac performance, and he has survived for over 6 years since the combined surgery. This combined method was feasible and appeared to be effective, and thus represents a promising strategy for treating severe heart failure in end-stage DCM and as an alternative treatment for selected patients who are not candidates for LVAD or HTx