Evolution of Beryllium and Boron in the Inhomogeneous Early Galaxy

A model of supernova-driven chemical evolution of the Galactic halo, recently proposed by Tsujimoto, Shigeyama, & Yoshii (1999, ApJL, 519, 64), is extended in order to investigate the evolution of light elements such as Be and B (BeB), which are produced mainly through spallative reactions with Galactic cosmic rays. In this model each supernova sweeps up the surrounding interstellar gas into a dense shell and directly enriches it with ejecta which consist of heavy elements produced in each Type II supernova with different progenitor masses. We propose a two-component source for GCRs such that both interstellar gas and fresh SN ejecta engulfed in the shell are accelerated by the shock wave. Our model results include: (1) a prediction of the intrinsic scatter in BeB and [Fe/H] abundances within the model, (2) a successful prediction of the observed linear trend between BeB and [Fe/H], (3) a proposal for using BeB as a cosmic clock, as an alternative to [Fe/H], and (4) a method for possibly constraining the BBN model from future observations of metal-poor stars.Comment: 3 color figures in 7 pages, accepted by ApJ Letter

Neurobiology of Depression and Anxiety in Parkinson's Disease

Depression and anxiety are common in Parkinson's disease (PD) and have important consequences on quality of life. These have long been recognized as frequent accompanying syndromes of PD, and several reports suggest that these are the causative process or risk factors that are present many years before the appearance of motor symptoms. The neurochemical changes in PD involving dopamine, norepinephrine, and serotonin might be related to the pathophysiology of depression and anxiety, but this is still not clear. Several studies showed that anxiety in PD patients occurs earlier than depression, during premotor phase, suggesting that there may be a link between the mechanisms that cause anxiety and PD. Whereas a recent study reported that PD patients with depression and anxiety were associated with different demographic and clinical features

Gelatin microspheres crosslinked with γ-ray : Preparation, sorption of proteins, and biodegradability

A new type of gelatin microspheres was manufactured with the crosslinking method by using γ-ray irradiation. Microspheres thus obtained were characterized by microscopic observation and enzymatic degradability. The mean diameter of the microspheres was in the range from 2.4 to 3.6 μm and the size distribution was quite small. The size decreased with increasing the shear rate of the emulsifier used in the preparation and was not affected by the radiation dose. The enzymatic degradability decreased with increasing the radiation dose and decreasing the gelatin concentration of the microsphere. In other words, the rate of the enzymatic decomposition of microspheres can be controlled by these two parameters. These trends were consistent with our previous results for the gel sheet made of gelatin. Their sorption of proteins was also investigated with the use of three types of proteins labeled by fluorescent pigment. From the fluorescence micrographs, it was observed that the gelatin microspheres adsorbed only proteins having the opposite charge.Terao, K., Karino, T., Nagasawa, N., Yoshii, F., Kubo, M. and Dobashi, T. (2004), Gelatin microspheres crosslinked with γ-ray: Preparation, sorption of proteins, and biodegradability. J. Appl. Polym. Sci., 91: 3083-3087. https://doi.org/10.1002/app.13574

Metabolism of Dietary and Microbial Vitamin B Family in the Regulation of Host Immunity

Vitamins are micronutrients that have physiological effects on various biological responses, including host immunity. Therefore, vitamin deficiency leads to increased risk of developing infectious, allergic, and inflammatory diseases. Since B vitamins are synthesized by plants, yeasts, and bacteria, but not by mammals, mammals must acquire B vitamins from dietary or microbial sources, such as the intestinal microbiota. Similarly, some intestinal bacteria are unable to synthesize B vitamins and must acquire them from the host diet or from other intestinal bacteria for their growth and survival. This suggests that the composition and function of the intestinal microbiota may affect host B vitamin usage and, by extension, host immunity. Here, we review the immunological functions of B vitamins and their metabolism by intestinal bacteria with respect to the control of host immunity

Alleviation of Brain Hypoperfusion after Preventative Treatment with Lomerizine in an Elderly Migraineur with Aura

Previous studies of brain single-photon emission tomography (SPECT) showed changes of regional cerebral blood flow (rCBF) in migraineurs during prodromes or headache attacks. Little is known about how successful medication of migraine prevention can reflect rCBF in migraineurs. We highlighted alternation of brain SPECT findings in a migraineur with aura before and after prophylactic treatment with lomerizine, a calcium channel blocker. A 70-year-old man with migraine developed visual disturbance frequently at walking exercise for the recent 3 months. After this visual attack, a mild-degree of throbbing headache occured occasionally. Brain SPECT using 99mTc-ethyl cysteinate dimer was performed at interictal time of migraine. Brain SPECT before lomerizine treatment revealed hypoperfusion in the frontal, parietal, and occipital regions. He was diagnosed with recurrence of migraine with aura (MA). Lomerizine (10 mg/day, po) was administered for 3 months. MA and visual aura without headache were dramatically improved. Migraine attacks and visual disturbance were not induced at exercise. At 3 months after lomerizine medication, brain SPECT showed remarkable increase of rCBF. These SPECT changes of our patient indicated that antimigraine mechanism of lomerizine could contribute to restoration of cerebral hypoperfusion

Nanometer-sized gelatin particles prepared by means of gamma-ray irradiation

Nanometer-sized gelatin particles have been prepared by means of gamma-ray irradiation and characterized by static and dynamic light scattering combined with circular dichroism measurements. The molecular weight of the nanoparticles was much larger than that of the original gelatin molecules, whereas the hydrodynamic radius was much smaller. Radius of gyration evaluated from the angular dependence of the static light scattering intensity decreased with increasing irradiation dose. Circular dichroism spectra of the gelatin nanoparticles were independent of temperature, and it is suggested that the nanoparticles consist of highly and randomly packed gelatin and their conformation is stable against the temperature change