Experimental Test of a New Equality: Measuring Heat Dissipation in an Optically Driven Colloidal System

Measurement of energy dissipation in small nonequilibrium systems is generally a difficult task. Recently, Harada and Sasa [Phys.Rev.Lett. 95, 130602(2005)] derived an equality relating the energy dissipation rate to experimentally accessible quantities in nonequilibrium steady states described by the Langevin equation. Here, we show the first experimental test of this new relation in an optically driven colloidal system. We find that this equality is validated to a fairly good extent, thus the irreversible work of a small system is estimated from readily obtainable quantities.Comment: 4 pages, 6 figure

Elastic Convection in Vibrated Viscoplastic Fluids

We observe a new type of behavior in a shear thinning yield stress fluid: freestanding convection rolls driven by vertical oscillation. The convection occurs without the constraint of container boundaries yet the diameter of the rolls is spontaneously selected for a wide range of parameters. The transition to the convecting state occurs without hysteresis when the amplitude of the plate acceleration exceeds a critical value. We find that a non-dimensional stress, the stress due to the inertia of the fluid normalized by the yield stress, governs the onset of the convective motion.Comment: 4 pages, 6 figure

Nonlinear Elasticity of Single Collapsed Polyelectrolytes

Nonlinear elastic responses of short and stiff polyelectrolytes are investigated by dynamic simulations on a single molecule level. When a polyelectrolyte condensate undergoes a mechanical unfolding, two types of force-extension curves, i.e., a force plateau and a stick-release pattern, are observed depending on the strength of the electrostatic interaction. We provide a physical interpretation of such force-extension behavior in terms of intramolecular structures of the condensates. We also describe a charge distribution of condensed counterions onto a highly stretched polyelectrolyte, which clarifies a formation of one-dimensional strongly correlated liquid at large Coulomb coupling regime where a stick-release pattern is observed. These findings may provide significant insights into the relationship between a molecular elasticity and a molecular mechanism of like-charge attractions observed in a wide range of charged biopolymer systems.Comment: 5pages, 5figure

Upregulation of IGF-I in the goldfish retinal ganglion cells during the early stage of optic nerve regeneration

金沢大学医薬保健研究域　医学系Goldfish retinal ganglion cells (RGCs) can regrow their axons after optic nerve injury. However, the reason why goldfish RGCs can regenerate after nerve injury is largely unknown at the molecular level. To investigate regenerative properties of goldfish RGCs, we divided the RGC regeneration process into two components: (1) RGC survival, and (2) axonal elongation processes. To characterize the RGC survival signaling pathway after optic nerve injury, we investigated cell survival/death signals such as Bcl-2 family members in the goldfish retina. Amounts of phospho-Akt (p-Akt) and phospho-Bad (p-Bad) in the goldfish retina rapidly increased four- to five-fold at the protein level by 3-5 days after nerve injury. Subsequently, Bcl-2 levels increased 1.7-fold, accompanied by a slight reduction in caspase-3 activity 10-20 days after injury. Furthermore, level of insulin-like growth factor-I (IGF-I), which activates the phosphatidyl inositol-3-kinase (PI3K)/Akt system, increased 2-3 days earlier than that of p-Akt in the goldfish retina. The cellular localization of these molecular changes was limited to RGCs. IGF-I treatment significantly induced phosphorylation of Akt, and strikingly induced neurite outgrowth in the goldfish retina in vitro. On the contrary, addition of the PI3K inhibitor wortmannin, and IGF-I antibody inhibited Akt phosphorylation and neurite outgrowth in an explant culture. Thus, we demonstrated, for the first time, the signal cascade for early upregulation of IGF-I, leading to RGC survival and axonal regeneration in adult goldfish retinas through PI3K/Akt system after optic nerve injury. The present data strongly indicate that IGF-I is one of the most important molecules for controlling regeneration of RGCs after optic nerve injury. © 2007 Elsevier Ltd. All rights reserved

X-ray diffractometry for the structure determination of a submicrometre single powder grain

A high-precision diffractometer with a synchrotron radiation microfocusing technique has been developed to investigate the crystal structure of a submicrometre-scale single grain of powder sample. The structure of a BaTiO3 single powder grain, of dimensions ∼600 × 600 × 300 nm, was determined

Risk factors and management of intraprocedural rupture during coil embolization of unruptured intracranial aneurysms: role of balloon guiding catheter

IntroductionIntraprocedural rupture (IPR) is a serious complication of endovascular coil embolization of unruptured intracranial aneurysms (UIAs). Although outcomes after IPR are poor, methods to prevent subsequent neurological deterioration have not yet been investigated. We evaluated the risk factors and management strategies for IPR, particularly the role of balloon guiding catheters (BGCs) in rapid hemostasis.MethodsWe retrospectively reviewed all UIA cases treated with coil embolization at three institutions between 2003 and 2021, focusing on preoperative radiological data, operative details, and outcomes.ResultsIn total, 2,172 aneurysms were treated in 2026 patients. Of these, 19 aneurysms in 19 patients (0.8%) ruptured during the procedure. Multivariate analysis revealed that aneurysms with a bleb (OR: 3.03, 95% CI: 1.21 to 7.57, p = 0.017), small neck size (OR: 0.56, 95% CI: 0.37 to 0.85, p = 0.007), and aneurysms in the posterior communicating artery (PcomA) (OR: 4.92, 95% CI: 1.19 to 20.18, p = 0.027) and anterior communicating artery (AcomA) (OR: 12.08, 95% CI: 2.99 to 48.79, p < 0.001) compared with the internal carotid artery without PcomA were significantly associated with IPR. The incidence of IPR was similar between the non-BGC and BGC groups (0.9% vs. 0.8%, p = 0.822); however, leveraging BGC was significantly associated with lower morbidity and mortality rates after IPR (0% vs. 44%, p = 0.033).DiscussionThe incidence of IPR was relatively low. A bleb, small aneurysm neck, and location on PcomA and AcomA are independent risk factors for IPR. The use of BGC may prevent fatal clinical deterioration and achieve better clinical outcomes in patients with IPR

The Subaru/XMM-Newton Deep Survey (SXDS) - VI. Properties of Active Galactic Nuclei Selected by Optical Variability

We present the properties of active galactic nuclei (AGN) selected by optical variability in the Subaru/XMM-Newton Deep Field (SXDF). Based on the locations of variable components and light curves, 211 optically variable AGN were reliably selected. We made three AGN samples; X-ray detected optically non-variable AGN (XA), X-ray detected optically variable AGN (XVA), and X-ray undetected optically variable AGN (VA). In the VA sample, we found a bimodal distribution of the ratio between the variable component flux and the host flux. One of these two components in the distribution, a class of AGN with a faint variable component $i'_{\rm{vari}}\sim25$ mag in bright host galaxies $i'\sim21$ mag, is not seen in the XVA sample. These AGN are expected to have low Eddington ratios if we naively consider a correlation between bulge luminosity and black hole mass. These galaxies have photometric redshifts $z_{\rm{photo}}\sim0.5$ and we infer that they are low-luminosity AGN with radiatively inefficient accretion flows (RIAFs). The properties of the XVA and VA objects and the differences from those of the XA objects can be explained within the unified scheme for AGN. Optical variability selection for AGN is an independent method and could provide a complementary AGN sample which even deep X-ray surveys have not found.Comment: 9 pages, 10 figures, accepted for publication in Ap

Verification of the Addiction Severity Index Japanese Version (ASI-J) as a Treatment-Customization, Prediction, and Comparison Tool for Alcohol-Dependent Individuals

Objective: To demonstrate the usefulness of the Addiction Severity Index Japanese Version (ASI-J) in Japanese alcohol-dependent individuals. The ASI is a frequently used clinical and research instrument that measures severities in seven functional domains in people with substance abuse disorders. Methods: A total of 370 male inpatients with a history of alcohol dependence participated in the study. Forty-nine participants were excluded in the final analysis due to lack of reliability (i.e., patient misrepresentation or inability to understand). We used the ASI-J and a series of indexes that determined patient states during and post-treatment. Results: The correlations between ASI Composite Scores (CSs), which were calculated through a weighted formula and indicated the severity of each problem area, were significant but low in eight relations and not significant in 13 relations, indicating substantial independence of the problem areas. Significant differences were found in Family/Social CSs between abstinent and relapsed alcohol-dependent individuals. The questions of undesirable attitude were significantly related to the CSs of Employment, Drug use, Family/Social, and Psychiatric sections. Significant differences were observed in patient demographics, CS, and ASI Severity Rating (SR) and interviewer’s subjective scoring between alcohol-dependent individuals and drug abusers. CSs in Japanese alcohol-dependent individuals were generally similar to corresponding CSs in individuals from other countries, with the exception of The Netherlands. Conclusions: This study demonstrated that the ASI-J is useful for understanding individual profiles of problems for each patient and planning customized treatment. The ASI-J served as a predictive tool for relapse and compliance to treatment afterward and was shown to be useful as a comparison tool in clarifying similarities and differences between substance abuser groups

The Subaru/XMM-Newton Deep Survey (SXDS) - V. Optically Faint Variable Object Survey

We present our survey for optically faint variable objects using multi-epoch (8-10 epochs over 2-4 years) $i'$-band imaging data obtained with Subaru Suprime-Cam over 0.918 deg$^2$ in the Subaru/XMM-Newton Deep Field (SXDF). We found 1040 optically variable objects by image subtraction for all the combinations of images at different epochs. This is the first statistical sample of variable objects at depths achieved with 8-10m class telescopes or HST. The detection limit for variable components is $i'_{\rm{vari}}\sim25.5$ mag. These variable objects were classified into variable stars, supernovae (SNe), and active galactic nuclei (AGN), based on the optical morphologies, magnitudes, colors, and optical-mid-infrared colors of the host objects, spatial offsets of variable components from the host objects, and light curves. Detection completeness was examined by simulating light curves for periodic and irregular variability. We detected optical variability for $36\pm2$ ($51\pm3$ for a bright sample with $i'<24.4$ mag) of X-ray sources in the field. Number densities of variable obejcts as functions of time intervals $\Delta{t}$ and variable component magnitudes $i'_{\rm{vari}}$ are obtained. Number densities of variable stars, SNe, and AGN are 120, 489, and 579 objects deg$^{-2}$, respectively. Bimodal distributions of variable stars in the color-magnitude diagrams indicate that the variable star sample consists of bright ($V\sim22$ mag) blue variable stars of the halo population and faint ($V\sim23.5$ mag) red variable stars of the disk population. There are a few candidates of RR Lyrae providing a possible number density of $\sim10^{-2}$ kpc$^{-3}$ at a distance of $>150$ kpc from the Galactic center.Comment: 18 pages, 17 figures, accepted for publication in Ap