Femtosecond Pulse Radiolysis

Ultrafast pulse radiolysis with a short-pulsed electron beam and a short-pulsed analyzing light is a powerful time-resolved spectroscopic technique to study the kinetics and reactions of short-lived intermediate species or precursors in radiation chemistry and biology. In this chapter, first, we give an overview of historical developments of ultrafast pulse radiolysis. Then, we describe a femtosecond pulse radiolysis instrument, including the generation of femtosecond electron pulses by a photocathode radio frequency (rf) gun-based linear electron accelerator, the synchronization of femtosecond analyzing laser with the electron pulses, the transient absorption measurement with double-pulse technique, and the observations of the formation processes and ultrafast reactions of hydrated electrons in water. Finally, two innovative techniques, which enable to improve the time resolution in next pulse radiolysis development, are presented

顎関節症患者の関節滑液中におけるアグリカナーゼの発現に関する検討

取得学位 : 博士（医学）, 学位授与番号 : 医博甲第1708号 , 学位授与年月日 : 平成17年6月30日, 学位授与大学 : 金沢大

Asymmetric desymmetrization of meso-diols by C(2)-symmetric chiral 4-pyrrolidinopyridines.

In this work we developed C(2)-symmetric chiral nucleophilic catalysts which possess a pyrrolidinopyridine framework as a catalytic site. Some of these organocatalysts effectively promoted asymmetric desymmetrization of meso-diols via enantioselective acylation

Cochlear implantation in patients with bilateral deafness caused by otitis media with ANCA-associated vasculitis (OMAAV): A report of four cases

Objective: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) without systemic symptoms but with initial symptoms related to the ear, such as hearing loss, otalgia, and dizziness, has recently been reported. We have categorized this condition as otitis media with AAV (OMAAV), and have recently proposed its diagnostic criteria. Methods: To determine the effectiveness of cochlear implantation (CI) in patients with profound hearing loss due to OMAAV. We examined the language understanding ability of four patients with bilateral profound or total deafness due to OMAAV, who underwent CI. Results: In three of the four patients, the language understanding ability with CI was poor. These three patients with poor performance had characteristic features, including a short interval from the onset of ear symptoms to total deafness and clear enhancement of the cochlea on magnetic resonance imaging (MRI). Conclusion: The poor results observed in patients with a rapidly progressive history of hearing loss were attributed to possible severe and profuse intracochlear bleeding and/or destruction of structures, including the spiral ganglion. All the three patients showed contrast enhancement in the inner ear on MRI. We believe that preoperative evaluation of the history of hearing loss as well as the findings of contrast-enhanced MRI is important for predicting the prognosis after CI

Development of Phonon Dynamics Measurement System by MIR- FEL and Pico-second Laser

FEL2015, Daejeon, Republic of KoreaCoherent control of a lattice vibration in bulk solid (mode-selective phonon excitation: MSPE) is one of the attractive methods in the solid state physics because it becomes a powerful tool for the study of ultrafast lattice dynamics (e.g. electron-phonon interaction and phonon-phonon interaction). Not only for that, MSPE can control electronic, magnetic, and structural phases of materials. In 2013, we have directly demonstrated MSPE of a bulk material with MIR-FEL (KU-FEL) by anti-Stokes Raman scattering spectroscopy. For the next step, we are starting a phonon dynamics measurement to investigate the difference of physical property between thermally excited phonon (phonon of equilibrium state) and optically excited phonon (phonon of non-equilibrium state) by time-resolved method in combination with a pico-second VIS laser. By using pico-second laser, we also expect to perform the anti-Stokes hyper-Raman scattering spectroscopy to extend MSPE method to the phonon mode which has Raman inactive . As the first step, we have commissioned the time-resolved phonon measurement system and started measurement on 6H-SiC. In this conference, we will present the outline of measurement system, and experimental results

Two elderly patients with advanced maxillary gingival carcinoma with complete response to concurrent radiotherapy and S-1 chemotherapy

金沢大学附属病院歯科口腔外科The use of the novel oral fluoropyrimidine anticancer drug S-1 as a single agent or in combined chemotherapy has been reported to be useful for the treatment of advanced oral cancer. We report two elderly patients with advanced oral cancer who achieved complete response (CR) after concurrent radiotherapy and S-1 chemotherapy. Patient 1 was an 81-year-old woman who had a 50. mm × 40. mm tumor erosion in the right upper gingival region. At 2.5 years after the end of concurrent radiotherapy and S-1 chemotherapy, tumor relapse was observed, although CR continued temporarily. The patient died 3 years after the end of concurrent radiotherapy and S-1 chemotherapy due to tumor relapse and high blood pressure resulting in deterioration of patient condition. Patient 2 was an 89-year-old woman who had a 40. mm × 30. mm tumor ulcer in the right gingiva. Neither relapse nor metastasis was seen, and patient condition remained good for the 3 years after concurrent radiotherapy and S-1 chemotherapy. In both patients, MRI showed that the tumor had deeply invaded the palatal bone, almost reaching the nasal cavity, with metastasis to the right upper superior internal jugular nodes. In both patients, biopsy showed a well-differentiated squamous cell carcinoma. Concurrent radiotherapy and S-1 chemotherapy induced CR without severe adverse effects. © 2010 Asian Association of Oral and Maxillofacial Surgeons

Comparison of maxillary stability after Le Fort I osteotomy for occlusal cant correction surgery and maxillary advanced surgery

金沢大学医学部附属病院歯科口腔外科Objective: To compare postoperative maxillary stability following Le Fort I osteotomy for the correction of occlusal cant as compared with conventional Le Fort I osteotomy for maxillary advancement. Study design: The subjects were 40 Japanese adults with jaw deformities. Of these, 20 underwent a Le Fort I osteotomy and intraoral vertical ramus osteotomy (IVRO) to correct asymmetric skeletal morphology and inclined occlusal cant. The other 20 patients underwent a Le Fort I osteotomy and sagittal split ramus osteotomy (SSRO) to advance the maxilla. Lateral and posteroanterior cephalograms were taken postoperatively and assessed statistically. Thereafter, the 2 groups were followed for time-course changes. Results: There was no significant difference between the 2 groups with regard to time-course changes during the immediate postoperative period. Conclusion: This suggests that maxillary stability after Le Fort I osteotomy for cant correction does not differ from that after Le Fort I osteotomy for maxillary advancement. © 2007 Mosby, Inc. All rights reserved

Evaluation of upper lip hypoesthesia with a trigeminal somatosensory-evoked potential following Le Fort I osteotomy in combination with mandibular osteotomy

金沢大学医学部附属病院歯科口腔外科Purpose: The purpose of this study was to objectively evaluate hypoesthesia of the upper lip following Le Fort I osteotomy in combination with mandibular osteotomy with trigeminal somatosensory evoked potential (TSEP). Subjects and methods: The subjects consisted of 25 patients with mandibular prognathism with maxillary retrognathism mandibular prognathism with or without asymmetry, who underwent Le Fort I osteotomy in combination with sagittal split ramus osteotomy (SSRO) or intraoral vertical ramus osteotomy (IVRO).Trigeminal nerve hypoesthesia at the region of the upper lip was assessed bilaterally by the TSEP method. The electrodes were placed exactly above the highest point of the vermilion border and on the mucosa of the upper lip. An electroencephalograph recording system (Neuropack Sigma; Nihon Koden Corp., Tokyo, Japan) was used to analyze the potentials. Each patient was evaluated preoperatively and then postoperatively at 1 week, 2 weeks, 1 month, 3 months, 6 months, and 1 year. Results: The average measurable period and standard deviation of TSEP of the upper lip was 7.8 ± 10.7 weeks following Le Fort I osteotomy, TSEP of the lower lip was 4.6 ± 9.2 weeks in the patients who underwent SSRO with Le Fort I osteotomy, and 1.2 ± 0.4 weeks in the patients who underwent IVRO with Le Fort I osteotomy. Conclusion: This study objectively proved that hypoesthesia could appear in the upper lips following Le Fort I osteotomy with TSEP. The measurable period for the upper lip following Le Fort I osteotomy tended to be longer than that for the lower lip in the patients who underwent SSRO and IVRO with Le Fort I osteotomy. © 2007 Mosby, Inc. All rights reserved

2α+t2\alpha+t cluster structure in 11^{11}B

The cluster structures of the excited states in $^{11}$B are studied by analyzing the isoscalar monopole and quadrupole strengths in the $^{11}$B($d$,$d'$) reaction at $E_d=200$ MeV. The excitation strengths are compared with the predictions by the shell-model and antisymmetrized molecular-dynamics (AMD) calculations. It is found that the large monopole strength for the $3/2^-_3$ state at $E_x=8.56$ MeV is well described by the AMD calculation and is an evidence for a developed $2\alpha+t$ cluster structure.Comment: Revised according to the referees' comment

Condylar and disc positions after intraoral vertical ramus osteotomy with and without a Le Fort I osteotomy

金沢大学医学部附属病院歯科口腔外科The purpose of this study was to examine the changes in temporomandibular joint (TMJ) morphology and clinical symptoms after intraoral vertical ramus osteotomy (IVRO) with and without a Le Fort I osteotomy. Of 50 Japanese patients with mandibular prognathism with mandibular and bimaxillary asymmetry, 25 underwent IVRO and 25 underwent IVRO in combination with a Le Fort I osteotomy. The TMJ symptoms and joint morphology, including disc tissue, were assessed preoperatively and postoperatively by magnetic resonance imaging and axial cephalogram. Improvement was seen in just 50% of joints with anterior disc displacement (ADD) that received IVRO and 52% of those that received IVRO with Le Fort I osteotomy. Fewer or no TMJ symptoms were reported postoperatively in 97% of the joints that received IVRO and 90% that received IVRO with Le Fort I osteotomy. Postoperatively, there were significant condylar position changes and horizontal changes in the condylar long axis on both sides in the two groups. There were no significant differences between improved ADD and unimproved ADD in condylar position change and the angle of the condylar long axis, although distinctive postoperative condylar sag was seen. These results suggest that IVRO with or without Le Fort I osteotomy can improve ADD and TMJ symptoms along with condylar position and angle, but it is difficult to predict the amount of improvement in ADD. © 2006 International Association of Oral and Maxillofacial Surgeons