Voting System for removing intergenerational inequality taking account of the population projection and space

科学研究費助成事業(学術研究助成基金助成金)研究成果報告書：挑戦的萌芽研究2011-2012課題番号：2365115

欧州における間接税競争・税調和政策の実態調査

科学研究費助成事業（科学研究費補助金）研究成果報告書：基盤研究(B) 平成14～17年度 課題番号：144020121.　日本における地域間消費税競争モデル-地方分権と税確保.....12.　Customer Mobility and Commodity Tax Competetion....293. Two-dimensional fiscal competetion........................................444. A spatial tax harmonization model.............................................575. 付加価値税に関する競争・協調モデル...........................................746.　現地調査データ6-1.ルクセンブルク高速道路サービスエリア給油車ナンバープレート調査...916-2.ベルギー・ルクセンブルグ　ガソリン価格調査...........................926-3.アンドラ・スペイン　ガソリン価格調査........................................942 以降については著作権保護のため、つくばリポジトリでの公開はいたしません

Fairness Scheduling in Dense User-Centric Cell-Free Massive MIMO Networks

We consider a user-centric scalable cell-free massive MIMO network with a total of $LM$ distributed remote radio unit antennas serving $K$ user equipments (UEs). Many works in the current literature assume $LM\gg K$, enabling high UE data rates but also leading to a system not operating at its maximum performance in terms of sum throughput. We provide a new perspective on cell-free massive MIMO networks, investigating rate allocation and the UE density regime in which the network makes use of its full capability. The UE density $K$ approximately equal to $\frac{LM}{2}$ is the range in which the system reaches the largest sum throughput. In addition, there is a significant fraction of UEs with relatively low throughput, when serving $K>\frac{LM}{2}$ UEs simultaneously. We propose to reduce the number of active UEs per time slot, such that the system does not operate at ``full load'', and impose throughput fairness among all users via a scheduler designed to maximize a suitably defined concave componentwise non-decreasing network utility function. Our numerical simulations show that we can tune the system such that a desired distribution of the UE throughput, depending on the utility function, is achieved

Overloaded Pilot Assignment with Pilot Decontamination for Cell-Free Systems

The pilot contamination in cell-free massive multiple-input-multiple-output (CF-mMIMO) must be addressed for accommodating a large number of users. In previous works, we have investigated a decontamination method called subspace projection (SP). The SP separates interference from co-pilot users by using the orthogonality of the principal components of the users' channel subspaces. Non-overloaded pilot assignment (PA), where each radio unit (RU) does not assign the same pilot to different users, limits the spectral efficiency (SE) of the system, since SP channel estimation is able to deal with co-pilot users that have nearly orthogonal subspaces. Motivated by this limitation, this paper introduces overloaded PA methods adjusted for the decontamination in order to improve the sum SE of CF systems. Numerical simulations show that the overloaded PA methods give higher SE than that of non-overloaded PA at a high user density scenario.Comment: 7 pages, 2 figures, this paper was submitted to IEEE WCNC 202

Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow

Mesenchymal stem cells (MSCs) are defined as cells that undergo sustained in vitro growth and can give rise to multiple mesenchymal lineages. Because MSCs have only been isolated from tissue in culture, the equivalent cells have not been identified in vivo and little is known about their physiological roles or even their exact tissue location. In this study, we used phenotypic, morphological, and functional criteria to identify and prospectively isolate a subset of MSCs (PDGFRα+Sca-1+CD45−TER119−) from adult mouse bone marrow. Individual MSCs generated colonies at a high frequency and could differentiate into hematopoietic niche cells, osteoblasts, and adipocytes after in vivo transplantation. Naive MSCs resided in the perivascular region in a quiescent state. This study provides the useful method needed to identify MSCs as defined in vivo entities

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

「コロナ制圧タスクフォース」COVID-19患者由来の血液細胞における遺伝子発現の網羅的解析 --重症度に応じた遺伝子発現の変化には、ヒトゲノム配列の個人差が影響する--. 京都大学プレスリリース. 2022-08-23.Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease that has caused millions of deaths, where comprehensive understanding of disease mechanisms is still unestablished. In particular, studies of gene expression dynamics and regulation landscape in COVID-19 infected individuals are limited. Here, we report on a thorough analysis of whole blood RNA-seq data from 465 genotyped samples from the Japan COVID-19 Task Force, including 359 severe and 106 non-severe COVID-19 cases. We discover 1169 putative causal expression quantitative trait loci (eQTLs) including 34 possible colocalizations with biobank fine-mapping results of hematopoietic traits in a Japanese population, 1549 putative causal splice QTLs (sQTLs; e.g. two independent sQTLs at TOR1AIP1), as well as biologically interpretable trans-eQTL examples (e.g., REST and STING1), all fine-mapped at single variant resolution. We perform differential gene expression analysis to elucidate 198 genes with increased expression in severe COVID-19 cases and enriched for innate immune-related functions. Finally, we evaluate the limited but non-zero effect of COVID-19 phenotype on eQTL discovery, and highlight the presence of COVID-19 severity-interaction eQTLs (ieQTLs; e.g., CLEC4C and MYBL2). Our study provides a comprehensive catalog of whole blood regulatory variants in Japanese, as well as a reference for transcriptional landscapes in response to COVID-19 infection

DOCK2 is involved in the host genetics and biology of severe COVID-19

「コロナ制圧タスクフォース」COVID-19疾患感受性遺伝子DOCK2の重症化機序を解明 --アジア最大のバイオレポジトリーでCOVID-19の治療標的を発見--. 京都大学プレスリリース. 2022-08-10.Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge. Here we conducted a genome-wide association study (GWAS) involving 2, 393 cases of COVID-19 in a cohort of Japanese individuals collected during the initial waves of the pandemic, with 3, 289 unaffected controls. We identified a variant on chromosome 5 at 5q35 (rs60200309-A), close to the dedicator of cytokinesis 2 gene (DOCK2), which was associated with severe COVID-19 in patients less than 65 years of age. This risk allele was prevalent in East Asian individuals but rare in Europeans, highlighting the value of genome-wide association studies in non-European populations. RNA-sequencing analysis of 473 bulk peripheral blood samples identified decreased expression of DOCK2 associated with the risk allele in these younger patients. DOCK2 expression was suppressed in patients with severe cases of COVID-19. Single-cell RNA-sequencing analysis (n = 61 individuals) identified cell-type-specific downregulation of DOCK2 and a COVID-19-specific decreasing effect of the risk allele on DOCK2 expression in non-classical monocytes. Immunohistochemistry of lung specimens from patients with severe COVID-19 pneumonia showed suppressed DOCK2 expression. Moreover, inhibition of DOCK2 function with CPYPP increased the severity of pneumonia in a Syrian hamster model of SARS-CoV-2 infection, characterized by weight loss, lung oedema, enhanced viral loads, impaired macrophage recruitment and dysregulated type I interferon responses. We conclude that DOCK2 has an important role in the host immune response to SARS-CoV-2 infection and the development of severe COVID-19, and could be further explored as a potential biomarker and/or therapeutic target