Cost- and Energy-Aware Multi-Flow Mobile Data Offloading Using Markov Decision Process

With the rapid increase in demand for mobile data, mobile network operators are trying to expand wireless network capacity by deploying wireless local area network (LAN) hotspots on which they can offload their mobile traffic. However, these network-centric methods usually do not fulfill the interests of mobile users (MUs). Taking into consideration many issues, MUs should be able to decide whether to offload their traffic to a complementary wireless LAN. Our previous work studied single-flow wireless LAN offloading from a MU's perspective by considering delay-tolerance of traffic, monetary cost and energy consumption. In this paper, we study the multi-flow mobile data offloading problem from a MU's perspective in which a MU has multiple applications to download data simultaneously from remote servers, and different applications' data have different deadlines. We formulate the wireless LAN offloading problem as a finite-horizon discrete-time Markov decision process (MDP) and establish an optimal policy by a dynamic programming based algorithm. Since the time complexity of the dynamic programming based offloading algorithm is still high, we propose a low time complexity heuristic offloading algorithm with performance sacrifice. Extensive simulations are conducted to validate our proposed offloading algorithms

Fast-Start Video Delivery in Future Internet Architectures with Intra-domain Caching

Current TCP/IP based network is suffering from the tremendous usage of IP. Recently, content centric network (CCN) is proposed as an alternative of the future network architecture. In CCN, data itself, which is authenticated and secured, is a name and can be directly requested at the network level instead of using IP and DNS. Moreover, routers in CCN have caching abilities. Then end users can obtain the data from routers instead of remote server if the content has been stored in the routers, thus the overall network performance could be improved by reducing the transmission hops. Orthogonally, video plays a more and more important role nowadays and dominates the network traffic. Response time of each video request greatly affects the quality of user experience (QoE), users may even abandon the requested video service if they have to wait for long time before the video playback. Hence how to provide fast-start video delivery in CCN is critical. In this paper, we target to provide users fast-start video delivery in CCN. Specifically, we design a new caching policy for popularity-aware video caching in topology-aware CCN. And we propose to encode the video using scalable video coding (SVC) for fast-start video delivery and cache each video layer separately following the designed caching policies. Given an assigned weight by users, the tradeoff between the waiting time and received video quality is studied. Simulations are conducted to verify the performances and the results show that the proposed scheme outperforms state-of-the-art schemes significantly in typical scenarios

Inter-Domain Popularity-aware Video Caching in Future Internet Architectures

Current TCP/IP based network is suffering from the usage of IP especially in the era of Internet of things (IoT). Recently Content Centric Network (CCN) is proposed as an alternative of the future network architecture. In CCN, data itself, which is authenticated and secured, is a name and can be directly requested at the network level instead of using IP and Domain Name System (DNS). Another difference between CCN and traditional networks is that the routers in CCN have the caching abilities. Then the end users can obtain the data from routers instead of from the remote server if the content has been stored in the router. Hence the overall network performance can be improved by reducing the required transmission hops and the advantage of the CCN caching has been shown in literature. In this paper, we design a new caching policy for the popularity-aware video caching in CCN to handle the `redundancy\u27 problem in the existing schemes, where the same content may be stored multiple times along the road from server to users, thus leading to a significant performance degradation. Simulations are conducted and we could observe that the proposed scheme performs better comparing with the existing caching policies.Location: Taipei, TAIWANDate: AUG 19-20, 201

Nationwide multicenter questionnaire surveys on countermeasures against antimicrobial resistance and infections in hospitals

[Background] The goals of the National Action Plan on Antimicrobial Resistance (AMR) of Japan include “implementing appropriate infection prevention and control” and “appropriate use of antimicrobials, ” which are relevant to healthcare facilities. Specifically, linking efforts between existing infection control teams and antimicrobial stewardship programs was suggested to be important. Previous studies reported that human resources, such as full-time equivalents of infection control practitioners, were related to improvements in antimicrobial stewardship. [Methods] We posted questionnaires to all teaching hospitals (n = 1017) regarding hospital countermeasures against AMR and infections. To evaluate changes over time, surveys were conducted twice (1st survey: Nov 2016, 2nd survey: Feb 2018). A latent transition analysis (LTA) was performed to identify latent statuses, which refer to underlying subgroups of hospitals, and effects of the number of members in infection control teams per bed on being in the better statuses. [Results] The number of valid responses was 678 (response rate, 66.7%) for the 1st survey and 559 (55.0%) for the 2nd survey. More than 99% of participating hospitals had infection control teams, with differences in activity among hospitals. Roughly 70% had their own intervention criteria for antibiotics therapies, whereas only about 60 and 50% had criteria established for the use of anti-methicillin-resistant Staphylococcus aureus antibiotics and broad-spectrum antibiotics, respectively. Only 50 and 40% of hospitals conducted surveillance of catheter-associated urinary tract infections and ventilator-associated pneumonia, respectively. Less than 50% of hospitals used maximal barrier precautions for central line catheter insertion. The LTA identified five latent statuses. The membership probability of the most favorable status in the 2nd study period was slightly increased from the 1st study period (23.6 to 25.3%). However, the increase in the least favorable status was higher (26.3 to 31.8%). Results of the LTA did not support a relationship between increasing the number of infection control practitioners per bed, which is reportedly related to improvements in antimicrobial stewardship, and being in more favorable latent statuses. [Conclusions] Our results suggest the need for more comprehensive antimicrobial stewardship programs and increased surveillance activities for healthcare-associated infections to improve antimicrobial stewardship and infection control in hospitals

Far-Infrared Census of Starburst-Seyfert Connection

Far-infrared flux densities are newly extracted from the IRAS database for the RSA and CfA complete samples of Seyfert galaxies. These data are used to classify the Seyfert galaxies into those where the far-infrared continuum emission is dominated by the active galactic nucleus (AGN), circumnuclear starburst, or host galaxy. While AGN-dominant objects consist of comparable numbers of Seyfert 1 and 2 galaxies, starburst- and host-dominant objects consist preferentially of Seyfert 2 galaxies. Thus, in addition to the dusty torus, the circumnuclear starburst region and host galaxy are important in hiding the broad-line region. Morphologically, starburst-dominant Seyfert galaxies are of later types and more strongly interacting than AGN-dominant Seyfert galaxies. In a later-type galaxy, the AGN central engine has a lower Eddington luminosity, and the gaseous content is higher. The gas is efficiently supplied to the starburst via a galaxy-galaxy interaction. Morphologies of host-dominant Seyfert galaxies are of various types. Since starbursts in Seyfert galaxies are older than those in classical starburst galaxies, we propose an evolution from starburst to starburst-dominant Seyfert to host-dominant Seyfert for a late-type galaxy. An evolution from AGN-dominant Seyfert to host-dominant Seyfert is proposed for an early-type galaxy. These sequences have durations of a few x 10^8 yr and occur repeatedly within a galaxy during its evolution from a late type to an early type.Comment: 27 pages (AASTeX 5.0), 3 ps files for 6 figures, to appear in The Astrophysical Journa

Novel insights into genetic characteristics of blaGES-encoding plasmids from hospital sewage

IntroductionThe prevalence of Guiana extended-spectrum (GES)-type carbapenemase producers is increasing worldwide, and hospital water environments are considered as potential reservoirs. However, the genetic features underlying this resistance are not yet fully understood. This study aimed to characterize blaGES-encoding plasmids from a single-hospital sewage sample in Japan.MethodsCarbapenemase producers were screened using carbapenemase-selective agar and polymerase chain reaction. Whole-genome sequencing analyzes were performed on the carbapenemase-producing isolates.ResultsEleven gram-negative bacteria (four Enterobacter spp., three Klebsiella spp., three Aeromonas spp., and one Serratia spp.) with blaGES-24 (n = 6), blaGES-6 (n = 4), and blaGES-5 (n = 1) were isolated from the sewage sample. Five blaGES-24 and a blaGES-5 were localized in IncP-6 plasmids, whereas three blaGES-6 plasmids were localized in IncC plasmids with IncF-like regions. The remaining blaGES-6 and blaGES-24 were, respectively, localized on IncFIB-containing plasmids with IncF-like regions and a plasmid with an IncW-like replication protein. The IncP-6 and IncW-like plasmids had a close genetic relationship with plasmids from Japan, whereas the IncC/IncF-like and IncFIB/IncF-like plasmids were closely related to those from the United States and Europe. All blaGES genes were located on the class 1 integron cassette of the Tn3 transposon-related region, and the IncC/IncF-like plasmid carried two copies of the integron cassette. Eight of the eleven blaGES-encoding plasmids contained toxin-antitoxin system genes.DiscussionThe findings on the plasmids and the novel genetic content from a single wastewater sample extend our understanding regarding the diversity of resistance and the associated spread of blaGES, suggesting their high adaptability to hospital effluents. These findings highlight the need for the continuous monitoring of environmental GES-type carbapenemase producers to control their dissemination

Molecular Characteristics of Extended-Spectrum Beta-Lactamases and qnr Determinants in Enterobacter Species from Japan

The incidence of extended-spectrum β-lactamases (ESBLs) has been increasing worldwide, but screening criteria for detection of ESBLs are not standardized for AmpC-producing Enterobacteriaceae such as Enterobacter species. In this study, we investigated the prevalence of ESBLs and/or AmpC β-lactamases in Japanese clinical isolates of Enterobacter spp. and the association of plasmid-mediated quinolone resistance (PMQR) determinants with ESBL producers. A total of 364 clinical isolates of Enterobacter spp. collected throughout Japan between November 2009 and January 2010 were studied. ESBL-producing strains were assessed by the CLSI confirmatory test and the boronic acid disk test. PCR and sequencing were performed to detect CTX-M, TEM, and SHV type ESBLs and PMQR determinants. For ESBL-producing Enterobacter spp., pulsed-field gel electrophoresis (PFGE) was performed using XbaI restriction enzyme. Of the 364 isolates, 22 (6.0%) were ESBL producers. Seven isolates of Enterobacter cloacae produced CTX-M-3, followed by two isolates producing SHV-12. Two isolates of Enterobacter aerogenes produced CTX-M-2. Of the 22 ESBL producers, 21 had the AmpC enzyme, and six met the criteria for ESBL production in the boronic acid test. We found a significant association of qnrS with CTX-M-3-producing E. cloacae. The 11 ESBL-producing Enterobacter spp. possessing blaCTX-M, blaSHV, or blaTEM were divided into six unique PFGE types. This is the first report about the prevalence of qnr determinants among ESBL-producing Enterobacter spp. from Japan. Our results suggest that ESBL-producing Enterobacter spp. with qnr determinants are spreading in Japan

Thymosin β10 Expression Driven by the Human TERT Promoter Induces Ovarian Cancer-Specific Apoptosis through ROS Production

Thymosin β10 (Tβ10) regulates actin dynamics as a cytoplasm G-actin sequestering protein. Previously, we have shown that Tβ10 diminishes tumor growth, angiogenesis, and proliferation by disrupting actin and by inhibiting Ras. However, little is known about its mechanism of action and biological function. In the present study, we establish a new gene therapy model using a genetically modified adenovirus, referred to as Ad.TERT.Tβ10, that can overexpress the Tβ10 gene in cancer cells. This was accomplished by replacing the native Tβ10 gene promoter with the human TERT promoter in Ad.TERT.Tβ10. We investigated the cancer suppression activity of Tβ10 and found that Ad.TERT.Tβ10 strikingly induced cancer-specific expression of Tβ10 as well as apoptosis in a co-culture model of human primary ovarian cancer cells and normal fibroblasts. Additionally, Ad.TERT.Tβ10 decreased mitochondrial membrane potential and increased reactive oxygen species (ROS) production. These effects were amplified by co-treatment with anticancer drugs, such as paclitaxel and cisplatin. These findings indicate that the rise in ROS production due to actin disruption by Tβ10 overexpression increases apoptosis of human ovarian cancer cells. Indeed, the cancer-specific overexpression of Tβ10 by Ad.TERT.Tβ10 could be a valuable anti-cancer therapeutic for the treatment of ovarian cancer without toxicity to normal cells

The potential impact of the COVID-19 pandemic on global antimicrobial and biocide resistance : an AMR Insights global perspective

The COVID-19 pandemic presents a serious public health challenge in all countries. However, repercussions of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections on future global health are still being investigated, including the pandemic’s potential effect on the emergence and spread of global antimicrobial resistance (AMR). Critically ill COVID-19 patients may develop severe complications, which may predispose patients to infection with nosocomial bacterial and/or fungal pathogens, requiring the extensive use of antibiotics. However, antibiotics may also be inappropriately used in milder cases of COVID-19 infection. Further, concerns such as increased biocide use, antimicrobial stewardship/infection control, AMR awareness, the need for diagnostics (including rapid and point-of-care diagnostics) and the usefulness of vaccination could all be components shaping the influence of the COVID-19 pandemic. In this publication, the authors present a brief overview of the COVID-19 pandemic and associated issues that could influence the pandemic’s effect on global AMR.This study was supported by internal funding.https://academic.oup.com/jacamram2022School of Health Systems and Public Health (SHSPH