Verifying Experimental Wet Bulb Globe Temperature Hindcasts Across the United States

Hot and humid heat exposures challenge the health of outdoor workers engaged in occupations such as construction, agriculture, first response, manufacturing, military, or resource extraction. Therefore, government institutes developed guidelines to prevent heat-related illnesses and death during high heat exposures. The guidelines use Wet Bulb Globe Temperature (WBGT), which integrates temperature, humidity, solar radiation, and wind speed. However, occupational heat exposure guidelines cannot be readily applied to outdoor work places due to limited WBGT validation studies. In recent years, institutions have started providing experimental WBGT forecasts. These experimental products are continually being refined and have been minimally validated with ground-based observations. This study evaluated a modified WBGT hindcast using the historical National Digital Forecast Database and the European Centre for Medium-Range Weather Forecasts Reanalysis v5. We verified the hindcasts with hourly WBGT estimated from ground-based weather observations. After controlling for geographic attributes and temporal trends, the average difference between the hindcast and in situ data varied from −0.64°C to 1.46°C for different Köppen-Geiger climate regions, and the average differences are reliable for decision making. However, the results showed statistically significant variances according to geographical features such as aspect, coastal proximity, land use, topographic position index, and Köppen-Geiger climate categories. The largest absolute difference was observed in the arid desert climates (1.46: 95% CI: 1.45, 1.47), including some parts of Nevada, Arizona, Colorado, and New Mexico. This research investigates geographic factors associated with systematic WBGT differences and points toward ways future forecasts may be statistically adjusted to improve accuracy

Spatial disparities in air conditioning ownership in Florida, United States

ABSTRACTThis study emphasizes the critical role of air conditioning (AC) in preventing heat-related illnesses such as heat exhaustion and heatstroke. The challenge of limited geographic coverage and outdated AC availability data hampers effective heat risk mapping and prevention efforts. We identified areas with significant AC needs and examined factors related to AC ownership in Florida, U.S. Local Indicators of Spatial Association results displayed distinct AC ownership disparities, with high-high clusters in coastal and metropolitan areas and AC-deficient clusters inland. Vulnerable urban communities, predominantly inhabited by marginalized groups, had limited to no AC availability. The Spatial Durbin Model results revealed a significant correlation between AC ownership and socioeconomic and urban factors. Notably, a higher proportion of AC-deficient households were in predominantly African-American neighborhoods, underscoring racial disparities in AC ownership. These findings provide valuable insights for targeted interventions to mitigate heat-related risks and adapt to evolving climate conditions in vulnerable neighborhoods

Vitamin C in Cancer: A Metabolomics Perspective

There is an ongoing interest in cellular antioxidants and oxidants as well as cellular mechanisms underlying their effects. Several reports suggest that vitamin C (L-ascorbic acid) functions as a pro-oxidant with selective toxicity against specific types of tumor cells. In addition, reduced glutathione plays an emerging role in reducing oxidative stress due to xenobiotic toxins such as metals and oxidants associated with diseases such as cancer, cardiovascular disease, and stroke. High-dose intravenous vitamin C and intravenous glutathione have been used as complementary, alternative, and adjuvant medicines. Here, we review the molecular mechanisms underlying the regulation of oxidation/reduction systems, focusing on the altered metabolomics profile in cancer cells following treatment with pharmacological vitamin C. This review focuses on the role of vitamin C in energy metabolism in terms of adenosine triphosphate, cysteine, and reduced glutathione levels, affecting cancer cell death

Supramolecular Velcro for Reversible Underwater Adhesion

X11123110sciescopu

Genome-Wide Association Study of Seed Morphology Traits in Senegalese Sorghum Cultivars

Sorghum is considered the fifth most important crop in the world. Despite the potential value of Senegalese germplasm for various traits, such as resistance to fungal diseases, there is limited information on the study of sorghum seed morphology. In this study, 162 Senegalese germplasms were evaluated for seed area size, length, width, length-to-width ratio, perimeter, circularity, the distance between the intersection of length & width (IS) and center of gravity (CG), and seed darkness and brightness by scanning and analyzing morphology-related traits with SmartGrain software at the USDA-ARS Plant Science Research Unit. Correlations between seed morphology-related traits and traits associated with anthracnose and head smut resistance were analyzed. Lastly, genome-wide association studies were performed on phenotypic data collected from over 16,000 seeds and 193,727 publicly available single nucleotide polymorphisms (SNPs). Several significant SNPs were found and mapped to the reference sorghum genome to uncover multiple candidate genes potentially associated with seed morphology. The results indicate clear correlations among seed morphology-related traits and potential associations between seed morphology and the defense response of sorghum. GWAS analysis listed candidate genes associated with seed morphologies that can be used for sorghum breeding in the future

The sexual brain, genes, and cognition: A machine-predicted brain sex score explains individual differences in cognitive intelligence and genetic influence in young children

Sex impacts the development of the brain and cognition differently across individuals. However, the literature on brain sex dimorphism in humans is mixed. We aim to investigate the biological underpinnings of the individual variability of sexual dimorphism in the brain and its impact on cognitive performance. To this end, we tested whether the individual difference in brain sex would be linked to that in cognitive performance that is influenced by genetic factors in prepubertal children (N = 9,658, ages 9-10 years old; the Adolescent Brain Cognitive Development study). To capture the interindividual variability of the brain, we estimated the probability of being male or female based on the brain morphometry and connectivity features using machine learning (herein called a brain sex score). The models accurately classified the biological sex with a test ROC-AUC of 93.32%. As a result, a greater brain sex score correlated significantly with greater intelligence (p(fdr) < .001, eta(2)(p) = .011-.034; adjusted for covariates) and higher cognitive genome-wide polygenic scores (GPSs) (p(fdr) < .001, eta(2)(p) < .005). Structural equation models revealed that the GPS-intelligence association was significantly modulated by the brain sex score, such that a brain with a higher maleness score (or a lower femaleness score) mediated a positive GPS effect on intelligence (indirect effects = .006-.009; p = .002-.022; sex-stratified analysis). The finding of the sex modulatory effect on the gene-brain-cognition relationship presents a likely biological pathway to the individual and sex differences in the brain and cognitive performance in preadolescence.N

Spatial disparities in air conditioning ownership in Florida, United States

This study emphasizes the critical role of air conditioning (AC) in preventing heat-related illnesses such as heat exhaustion and heatstroke. The challenge of limited geographic coverage and outdated AC availability data hampers effective heat risk mapping and prevention efforts. We identified areas with significant AC needs and examined factors related to AC ownership in Florida, U.S. Local Indicators of Spatial Association results displayed distinct AC ownership disparities, with high-high clusters in coastal and metropolitan areas and AC-deficient clusters inland. Vulnerable urban communities, predominantly inhabited by marginalized groups, had limited to no AC availability. The Spatial Durbin Model results revealed a significant correlation between AC ownership and socioeconomic and urban factors. Notably, a higher proportion of AC-deficient households were in predominantly African-American neighborhoods, underscoring racial disparities in AC ownership. These findings provide valuable insights for targeted interventions to mitigate heat-related risks and adapt to evolving climate conditions in vulnerable neighborhoods.</p

Hazardous heat exposure among incarcerated people in the United States

Climate change is predicted to increase the frequency of potentially hazardous heat conditions across the United States, putting the incarcerated population of 2 million at risk for heat-related health conditions. We evaluate the exposure to potentially hazardous heat for 4,078 continental US carceral facilities during 1982–2020. Results show that the number of hot days per year increased during 1982–2020 for 1,739 carceral facilities, primarily located in the southern United States. State-run carceral facilities in Texas and Florida accounted for 52% of total exposure, despite holding 12% of all incarcerated people. This highlights the urgency for enhanced infrastructure, health system interventions and treatment of incarcerated people, especially under climate change