Quantum Artificial Intelligence on Cryptanalysis

With the recent development of quantum computers, various studies on quantum artificial intelligence technology are being conducted. Quantum artificial intelligence can improve performance in terms of accuracy and memory usage compared to deep learning on classical computers. In this work, we proposed an attack technique that recovers keys by learning patterns in cryptographic algorithms by applying quantum artificial intelligence to cryptanalysis. Cryptanalysis was performed in the current practically usable quantum computer environment, and this is the world\u27s first study to the best of our knowledge. As a result, we reduced 70 epochs and reduced the parameters by 19.6%. In addition, higher average BAP (Bit Accuracy Probability) was achieved despite using fewer epochs and parameters. For the same epoch, the method using a quantum neural network achieved a 2.8% higher BAP with fewer parameters. In our approach, quantum advantages in accuracy and memory usage were obtained with quantum neural networks. It is expected that the cryptanalysis proposed in this work will be better utilized if a larger-scale stable quantum computer is developed in the future

Taurine in drinking water recovers learning and memory in the adult APP/PS1 mouse model of Alzheimer's disease

Alzheimer's disease (AD) is a lethal progressive neurological disorder affecting the memory. Recently, US Food and Drug Administration mitigated the standard for drug approval, allowing symptomatic drugs that only improve cognitive deficits to be allowed to accelerate on to clinical trials. Our study focuses on taurine, an endogenous amino acid found in high concentrations in humans. It has demonstrated neuroprotective properties against many forms of dementia. In this study, we assessed cognitively enhancing property of taurine in transgenic mouse model of AD. We orally administered taurine via drinking water to adult APP/PS1 transgenic mouse model for 6 weeks. Taurine treatment rescued cognitive deficits in APP/PS1 mice up to the age-matching wild-type mice in Y-maze and passive avoidance tests without modifying the behaviours of cognitively normal mice. In the cortex of APP/PS1 mice, taurine slightly decreased insoluble fraction of Aβ. While the exact mechanism of taurine in AD has not yet been ascertained, our results suggest that taurine can aid cognitive impairment and may inhibit Aβ-related damages.MIT International Science and Technology InitiativesKorea Health Industry Development Institute (H14C04660000)Korea Institute of Science and Technology (Open Research 2E24582)Korea Institute of Science and Technology (Flagship 2E25023

Capillary force lithography with impermeable molds

Capillary force lithography (CFL) with impermeable mold is presented. For the CFL to be operative over large area, either the mold or the substrate has to be flexible. With a silicon wafer mold and a flexible substrate, a repeated line and space pattern with a spacing of 30 nm is shown to be well patterned. With a flexible mold and a hard substrate, a similar pattern with a spacing of 60 nm is demonstrated by CFL. The flexibility is needed for the intimate contact that is required between the mold and the substrate for the capillarity to take hold over large area. The forte of CFL with impermeable mold lies in the fact that the driving force for the patterning, which is capillary force, increases with decreasing pattern size.This work was supported by the Korea Foundation Grant funded by MOEHRD (KRF-2005-041-D00250)

Medical students’ thought process while solving problems in 3 different types of clinical assessments in Korea: clinical performance examination, multimedia case-based assessment, and modified essay question

Purpose This study aimed to explore students’ cognitive patterns while solving clinical problems in 3 different types of assessments—clinical performance examination (CPX), multimedia case-based assessment (CBA), and modified essay question (MEQ)—and thereby to understand how different types of assessments stimulate different patterns of thinking. Methods A total of 6 test-performance cases from 2 fourth-year medical students were used in this cross-case study. Data were collected through one-on-one interviews using a stimulated recall protocol where students were shown videos of themselves taking each assessment and asked to elaborate on what they were thinking. The unit of analysis was the smallest phrases or sentences in the participants’ narratives that represented a meaningful cognitive occurrence. The narrative data were reorganized chronologically and then analyzed according to the hypothetico-deductive reasoning framework for clinical reasoning. Results Both participants demonstrated similar proportional frequencies of clinical reasoning patterns on the same clinical assessments. The results also revealed that the three different assessment types may stimulate different patterns of clinical reasoning. For example, the CPX strongly promoted the participants’ reasoning related to inquiry strategy, while the MEQ strongly promoted hypothesis generation. Similarly, data analysis and synthesis by the participants were more strongly stimulated by the CBA than by the other assessment types. Conclusion This study found that different assessment designs stimulated different patterns of thinking during problem-solving. This finding can contribute to the search for ways to improve current clinical assessments. Importantly, the research method used in this study can be utilized as an alternative way to examine the validity of clinical assessments

Prevalence of Treated Epilepsy in Korea Based on National Health Insurance Data

The Korean national health security system covers the entire population and all medical facilities. We aimed to estimate epilepsy prevalence, anticonvulsant utilization pattern and the cost. We identified prevalent epilepsy patients by the prescription of anticonvulsants under the diagnostic codes suggesting seizure or epilepsy from 2007 Korean National Health Insurance databases. The information of demography, residential area, the kind of medical security service reflecting economic status, anticonvulsants, and the costs was extracted. The overall prevalence of treated epilepsy patients was 2.41/1,000, and higher for men than women. The age-specific prevalence was the lowest in those in their thirties and forties. Epilepsy was more prevalent among lower-income individuals receiving medical aid. The regional prevalence was the highest in Jeju Island and lowest in Ulsan city. New anticonvulsants were more frequently used than old anticonvulsants in the younger age group. The total annual cost of epilepsy or seizure reached 0.46% of total medical expenditure and 0.27% of total expenditure on health. This is the first nationwide epidemiological report issued on epilepsy in Korea. Epilepsy prevalence in Korea is comparable to those in developed countries. Economic status and geography affect the prevalence of epilepsy

Is focusing enough in category learning?

We examined whether selective attention, which is mainly theorized as the ability to focus on the category-relevant dimension, is a sole construct in understanding category learning. As the attention literature dissociates selective attention into focusing and filtering, we argue that filtering is another component that should be considered to fully understanding category learning. In the study, we provide an experimental paradigm that can dissociate filtering from focusing. By utilizing the paradigm along with collecting individual attention control measures, we show that filtering is related to the ability to inhibit irrelevant information. We also present that the current computational models that incorporate selective attention only as an ability to focus can not explain the results from the current study

Novel Enhanced Mammalian Cell Transient Expression Vector via Promoter Combination

During the emergence of infectious diseases, evaluating the efficacy of newly developed vaccines requires antigen proteins. Available methods enhance antigen protein productivity; however, structural modifications may occur. Therefore, we aimed to construct a novel transient overexpression vector capable of rapidly producing large quantities of antigenic proteins in mammalian cell lines. This involved expanding beyond the exclusive use of the human cytomegalovirus (CMV) promoter, and was achieved by incorporating a transcriptional enhancer (CMV enhancer), a translational enhancer (woodchuck hepatitis virus post-transcriptional regulatory element), and a promoter based on the CMV promoter. Twenty novel transient expression vectors were constructed, with the vector containing the human elongation factor 1-alpha (EF-1a) promoter showing the highest efficiency in expressing foreign proteins. This vector exhibited an approximately 27-fold higher expression of enhanced green fluorescent protein than the control vector containing only the CMV promoter. It also expressed the highest level of severe acute respiratory syndrome coronavirus 2 receptor-binding domain protein. These observations possibly result from the simultaneous enhancement of the transcriptional activity of the CMV promoter and the human EF-1a promoter by the CMV enhancer. Additionally, the synergistic effect between the CMV and human EF-1a promoters likely contributed to the further enhancement of protein expression

Analysis of the technical status of multiunit risk assessment in nuclear power plants

Since the Fukushima Daiichi nuclear disaster, concern and worry about multiunit accidents have been increasing. Korea has a higher urgency to evaluate its site risk because its number of nuclear power plants (NPPs) and population density are higher than those in other countries. Since the 1980s, technical documents have been published on multiunit probabilistic safety assessment (PSA), but the Fukushima accident accelerated research on multiunit PSA. It is therefore necessary to summarize the present situation and draw implications for further research. This article reviews journal and conference papers on multiunit or site risk evaluation published between 2011 and 2016. The contents of the reviewed literature are classified as research status, initiators, and methodologies representing dependencies, and the insights and conclusions are consolidated. As of 2017, the regulatory authority and nuclear power utility have launched a full-scale project to assess multiunit risk in Korea. This article provides comprehensive reference materials on the necessary enabling technology for subsequent studies of multiunit or site risk assessment. Keywords: Multiunit, Nuclear Power Plant, Probabilistic Safety Assessment, Site Risk Assessmen