Dynamic analysis of Th1/Th2 cytokine concentration during antiretroviral therapy of HIV-1/HCV co-infected Patients

<p>Abstract</p> <p>Background</p> <p>Co-infection with hepatitis C (HCV) is very common in human immunodeficiency virus 1 (HIV-1) infected patients. Although HIV co-infection clearly accelerates progression of HCV-related fibrosis and liver disease, controversy remains as to the impact of HCV on HIV disease progression in co-infected patients. HIV can cause immune dysfunction, in which the regulatory function of T helper (Th) cells is very essential. Moreover, cytokines derived from Th cells play a prominent role in viral infection. Investigating the functional changes of Th1 and Th2 cells in cytokine level can improve the understanding of the effect of co-infected HCV on HIV infection.</p> <p>Methods</p> <p>In this study, we measured the baseline Th1/Th2 cytokine concentration in sera by using flow cytometry in HIV/HCV co-infection, HIV mono-infection, HCV mono-infection, and healthy control group, as well as the dynamic changes of these cytokine levels after receiving highly active antiretroviral therapy (HAART).</p> <p>Results</p> <p>The ratio of Th1 and Th2 cytokine concentration in HIV/HCV co-infection was higher than HCV mono-infection and healthy control group, while lower than HIV mono-infection group. After HAART was initiated, the Th1/Th2 ratio of HIV/HCV co-infection group decreased to the same level of healthy control, while HIV mono-infection group was still higher than the control group.</p> <p>Conclusions</p> <p>There was no significant evidence showing co-infected with HCV had negative effect on HIV related diseases. However, co-infected with HCV can decrease Th1/Th2 ratio by affecting Th1 cytokine level, especially the secretion of IFN-γ. With the initiation of HAART, Th1 and Th2 cytokine levels were progressively reduced. HIV was the main stimulating factor of T cells in HIV/HCV co-infection group.</p

X-ray emission for 424 MeV/u C ions impacting on selected targets

In inertial Confinement Fusion (ICF), X-ray radiation drives the implosion requiring not only sufficient conversion efficiency of the drive energy to the X-ray but also the highly spatial symmetry..

Lateglacial and Holocene climate change in the NE Tibetan Plateau : Reconciling divergent proxies of Asian summer monsoon variability

The nature of Holocene Asian summer monsoon (ASM) evolution documented by diverse natural archives remains controversial, with a contentious issue being whether or not a strong Asian summer monsoon prevailed during the early Holocene. Here we present sequences of multiple proxies measured in sediment cores from Genggahai Lake in the NE Tibetan Plateau (NETP). The results suggest that a higher lake level and relatively lower terrestrial vegetation cover occurred synchronously during the early Holocene (11.3–8.6 kyr cal BP), compared with the period from 8.6 to 6.9 kyr cal BP. This finding clearly reflects the existence of different hydroclimatic conditions between the lake and its catchment due to diverse driving mechanisms. The early Holocene high stand of the lake, as demonstrated by the stratigraphic variability of the remains of aquatic biota, may have responded to the strengthened ASM and increased monsoonal precipitation; the relatively low vegetation cover in the marginal region of the Asian monsoon during the early Holocene, and the coeval widespread active sand dune mobility in both the NE Tibetan Plateau and NE China, most likely resulted from a low level of effective moisture due to high evaporation, and hence they cannot be interpreted as evidence of a weak ASM. Our results potentially reconcile the current divergent interpretations of various proxy climate records from the region. Our findings suggest that the ASM evolution was characterized by a consistent pattern across the monsoonal regions, as indicated by the oxygen isotope record of Chinese speleothems.Peer reviewe