Modeling the hard states of XTE J1550--564 during its 2000 outburst

We study hard states of the black-hole binary XTE J1550--564 during its 2000 outburst. In order to explain those states at their highest luminosities, $L\sim 10$ of the Eddington luminosity, $L_{\rm E}$, we propose a specific hot accretion flow model. We point out that the highest values of the hard-state $L$ are substantially above the $L$ an advection-dominated accretion flow (ADAF) can produce, $\sim 0.4\alpha^2 L_{\rm E}$, which is only $\sim (3$--$4)$ even for $\alpha$ as high as 0.3. On the other hand, we successfully explain the hard states with $L\sim (4$--$10)$ using the luminous hot accretion flow (LHAF) model. As $10$ is also roughly the highest luminosity an LHAF can produce, such an agreement between the predicted and observed highest luminosities provides by itself strong support for this model. Then, we study multi-waveband spectral variability during the 2000 outburst. In addition to the primary maxima in the optical light curves, secondary maxima were detected after the transition from the very high state to the hard state. We show that the secondary maxima are well modeled by synchrotron emission from a jet formed during the state transition. We argue that the absence of the corresponding secondary peak in the X-ray light curve indicates that the X-ray jet emission, regardless of its radiative process, synchrotron or its Comptonization, is not important in the hard state compared to the emission from the accretion flow.Comment: 23 pages, 4 figures; the final version to appear in Ap

Exploring the Design Space of Employing AI-Generated Content for Augmented Reality Display

As the two most common display content of Augmented Reality (AR), the creation process of image and text often requires a human to execute. However, due to the rapid advances in Artificial Intelligence (AI), today the media content can be automatically generated by software. The ever-improving quality of AI-generated content (AIGC) has opened up new scenarios employing such content, which is expected to be applied in AR. In this paper, we attempt to explore the design space for projecting AI-generated image and text into an AR display. Specifically, we perform an exploratory study and suggest a ``user-function-environment'' design thinking by building a preliminary prototype and conducting focus groups based on it. With the early insights presented, we point out the design space and potential applications for combining AIGC and AR

X-ray Spectral Variability of TeV Blazars during Rapid Flares

The spectral energy distribution (SED) of TeV blazars peaks both at keV and TeV energies. The X-ray emission is generally believed to originate in the synchrotron emission from relativistic electrons (and positrons) in the jet of these sources, while the origin of the gamma-ray emission is still being debated. We report results from a systematic study of X-ray spectral variability of Mrk 421 and Mrk 501 during individual flares that last for several days, making use of some of the high-quality data that have recently become available. The X-ray spectra of the two sources fall on the opposite sides of the synchrotron peak of their respective SEDs, so they together may offer additional insights into the physical origin of X-ray variability. We modeled each of the time-resolved X-ray spectra over a {\em single} flare by adopting a homogeneous spatial distribution and an instantaneous power-law spectral distribution for the emitting particles. We focused on the variation of four key parameters: particle spectral index, maximum Lorentz factor, energy density, and magnetic field. While there is considerable degeneracy in the fits, we show that, in order to account for the X-ray spectral variability observed in Mrk 421, at least three of the parameters are required to vary in most cases, with the spectral index being one of them. The observations of Mrk 501 support the conclusion, although the quality of the data is not as good. We discuss the implications of the results.Comment: 17 pages, 4 figures, 4 tables, accepted by ApJ; one typo (unit of E_tot) correcte

Overexpression of Wnt7b antagonizes the inhibitory effect of dexamethasone on osteoblastogenesis of ST2 cells

Introduction: It is well established that glucocorticoid-induced osteoporosis is highly associated with preosteoblast differentiation and function. This study is based on the premise that Wnt7b can promote bone formation through Wnt signalling pathway because it can stimulate preosteoblast differentiation and increase its activity. However, it is unknown whether Wnt7b can rescue the inhibited osteoblast differentiation and function caused by exogenous glucocorticoid. Material and methods: In this study we used Wnt7b overexpression ST2 cells to explore whether Wnt7bcan rescue the inhibited osteoblast differentiation and function, which can provide strong proof to investigate a new drug for curing the glucocorticoid induced osteoporosis. Results/Conclusion: We found that Wnt7b can rescue the suppressed osteoblast differentiation and function without cell viability caused by dexamethasone

Characterization of Montmorillonite–Biochar Composite and Its Application in the Removal of Atrazine in Aqueous Solution and Soil

Atrazine is a widely used triazine herbicide, which poses a serious threat to human health and aquatic ecosystem. A montmorillonite–biochar composite (MMT/BC) was prepared for atrazine remediation. Biochar samples were characterized by using scanning electron microscope (SEM), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), and X-ray photoelectron spectrometer (XPS). Structural and morphological analysis of raw biochar (BC) and MMT/BC showed that MMT particles have been successfully coated on the surface of biochar. Sorption experiments in aqueous solution indicated that the MMT/BC has higher removal capacity of atrazine compared to BC (about 3.2 times). The sorption of atrazine on the MMT/BC was primarily controlled by both physisorption and chemisorption mechanisms. The amendment of MMT/BC increased the sorption capacity of soils and delayed the degradation of atrazine. Findings from this work indicate that the MMT/BC composite can effectively improve the sorption capacity of atrazine in aquatic environment and farmland soil and reduce the environmental risk.Characterization of Montmorillonite–Biochar Composite and Its Application in the Removal of Atrazine in Aqueous Solution and SoilpublishedVersio

Accretion Disk Spectra of the Brightest Ultra-luminous X-ray Source in M82

Emission spectra of hot accretion disks characteristic of advection dominated accretion flow (ADAF) models are investigated for comparison with the brightest ultra-luminous source, X-1, in the galaxy M82. If the spectral state of the source is similar to the low luminosity hard state of stellar mass black holes in our Galaxy, a fit to the {\it Chandra} X-ray spectrum and constraints from the radio and infrared upper limits, require a black hole mass in the range of 9 \times 10^4 - 5 \times 10^5 \msun. Lower black hole masses (\la 10^4 \msun) are possible if M82 X-1 corresponds to the high luminosity hard state of Galactic black hole X-ray binary sources. Both of these spectrally degenerate hot accretion disk solutions lead to an intermediate mass black hole interpretation for M82 X-1. Since these solutions have different spectral variability with X-ray luminosity and predict different infrared emission, they can be distinguished by future off axis {\it Chandra} observations or simultaneous sensitive infrared detections.Comment: 17 pages, 2 figures; accepted by Ap

HMGB1 can activate cartilage progenitor cells in response to cartilage injury through the CXCL12/CXCR4 pathway

Introduction: Recent studies have suggested that cartilage progenitor cells (CPCs) could be activated and differentiated into chondrocytes to produce matrix and to restore the integrity of damaged cartilage after injury. However, the mechanism involved in CPC activation upon damage is still unclear. This study aims to investigate the role of high mobility group box chromosomal protein 1 (HMGB1) in both activation and migration of CPCs during cartilage injury. Material and methods: Explants harvested from mature bovine stifle joints were used for impact injury. The proliferation and migration of CPCs were examined via confocal imaging. Gene and protein expression of Hmbg1, Cxcl12, and Cxcr4 was also examined by quantitative polymerase chain reaction (qPCR), ELISA, and western blot. Each experiment was repeated 3 times. ANOVA and Student’s t-test were performed for statistical analysis. Results: HMGB1 released from dead and damaged chondrocytes after an impact injury could activate CPCs in the superficial zone of cartilage and promote their migration and proliferation to injury sites. However, the block of HMGB1 activation with its specific binding inhibitor glycyrrhizin inhibits the proliferation and migration of CPCs. Further investigations demonstrate that HMGB1 promotes CPCs migration through the pathway of C-X-C motif chemokine 12 (CXCL12) and its receptor CXCR4. Quantitative analysis of HMGB1 in cell culture medium also indicates that CPCs may have a self-activation property after the HMGB1 released from dead cells has been exhausted. Conclusion: HMGB1 is a pivotal factor that could enhance the migration and proliferation of CPCs through the CXCL12/CXCR4 pathway after cartilage injury, which could provide useful information for cartilage repair and osteoarthritis treatment

Downregulation of RPL6 by siRNA Inhibits Proliferation and Cell Cycle Progression of Human Gastric Cancer Cell Lines

Our previous study revealed that human ribosomal protein L6 (RPL6) was up-regulated in multidrug-resistant gastric cancer cells and over-expression of RPL6 could protect gastric cancer from drug-induced apoptosis. It was further demonstrated that up-regulation of RPL6 accelerated growth and enhanced in vitro colony forming ability of GES cells while down-regulation of RPL6 exhibited the opposite results. The present study was designed to investigate the potential role of RPL6 in therapy of gastric cancer for clinic. The expression of RPL6 and cyclin E in gastric cancer tissues and normal gastric mucosa was evaluated by immunohistochemisty. It was found that RPL6 and cyclin E were expressed at a higher level in gastric cancer tissues than that in normal gastric mucosa and the two were correlative in gastric cancer. Survival time of postoperative patients was analyzed by Kaplan- Meier analysis and it was found that patients with RPL6 positive expression showed shorter survival time than patients that with RPL6 negative expression. RPL6 was then genetically down-regulated in gastric cancer SGC7901 and AGS cell lines by siRNA. It was demonstrated that down-regulation of RPL6 reduced colony forming ability of gastric cancer cells in vitro and reduced cell growth in vivo. Moreover, down-regulation of RPL6 could suppress G1 to S phase transition in these cells. Further, we evidenced that RPL6 siRNA down-regulated cyclin E expression in SGC7901 and AGS cells. Taken together, these data suggested that RPL6 was over-expressed in human gastric tissues and caused poor prognosis. Down-regulation of RPL6 could suppress cell growth and cell cycle progression at least through down-regulating cyclin E and which might be used as a novel approach to gastric cancer therapy

Degradation of difenoconazole in water and soil: Kinetics, degradation pathways, transformation products identification and ecotoxicity assessment

Difenoconazole is a widely used triazole fungicide that has been frequently detected in the environment, but comprehensive study about its environmental fate and toxicity of potential transformation products (TPs) is still lacking. Here, laboratory experiments were conducted to investigate the degradation kinetics, pathways, and toxicity of transformation products of difenoconazole. 12, 4 and 4 TPs generated by photolysis, hydrolysis and soil degradation were identified via UHPLC-QTOF/MS and the UNIFI software. Four intermediates TP295, TP295A, TP354A and TP387A reported for the first time were confirmed by purchase or synthesis of their standards, and they were further quantified using UHPLC-MS/MS in all tested samples. The main transformation reactions observed for difenoconazole were oxidation, dechlorination and hydroxylation in the environment. ECOSAR prediction and laboratory tests showed that the acute toxicities of four novel TPs on Brachydanio rerio, Daphnia magna and Selenastrum capricornutum are substantially lower than that of difenoconazole, while all the TPs except for TP277C were predicted chronically very toxic to fish, which may pose a potential threat to aquatic ecosystems. The results are important for elucidating the environmental fate of difenoconazole and assessing the environmental risks, and further provide guidance for scientific and reasonable use.acceptedVersio

A novel method for objectively, rapidly and accurately evaluating burn depth via near infrared spectroscopy

The accurate and objective evaluation of burn depth is a significant challenge in burn wound care. Herein, we used near infrared spectroscopy (NIRS) technology to measure the different depth of thermal burns in ex vivo porcine models. Based on the intensity of the spectral signals and the diffuse reflection theory, we extracted the optical parameters involved in functional (total hemoglobin and water content) and structural (tissue scattered size and scattered particles) features that reflect the changes in burn depth. Next, we applied support vector regression to construct a model including the optical property parameters and the burn depth. Finally, we histologically verified the burn depth data collected via NIRS. The results showed that our inversion model could achieve an average relative error of about 7.63%, while the NIRS technology diagnostic accuracy was in the range of 50 μm. For the first time, this novel technique provides physicians with real-time burn depth information objectively and accurately