Particle Simulation of Plume Flows From an Anode Layer Hall Thruster

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/76948/1/AIAA-2006-5026-913.pd

Effect of a Magnetic Field in Simulating the Very Near-Field Plume of an Anode Layer Hall Thruster

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/77305/1/AIAA-2007-5268-964.pd

Modeling an Anode Layer Hall Thruster and its Plume.

A study of the D55 Hall thruster are performed. The first part of this thesis investigates the xenon plasma properties within the D55 Hall thruster channel using a hydrodynamic model. The discharge voltage (V) and current (I) characteristic thruster are studied. The hydrodynamic model fails to accurately predict the V-I characteristics. This analysis shows that the model needs to be improved. Also, the hydrodynamic model is used to simulate the plasma flow within the D55 Hall thruster. This analysis is performed to investigate the plasma properties of the channel exit. It is found that the hydrodynamic model is very sensitive to initial conditions, and fails to simulate the complete domain of the D55 Hall thruster. However, the model successfully calculates the channel domain of the D55 thruster. The results show that, at the thruster exit, the plasma density has a maximum while the ion velocity has a minimum at the channel center. The results show that the flow angle varies almost linearly across the exit plane and increases from the center to the walls. The second part of the thesis presents axisymmetric simulations of the xenon plasma plume flow fields from the D55 Hall thruster. A hybrid particle-fluid method is used for the simulations. The magnetic field near the thruster exit is included in the calculation. The plasma properties obtained from the hydrodynamic model are used to determine boundary conditions for the simulations. The Boltzmann model and a detailed fluid model are used to compute the electron properties, the direct simulation Monte Carlo method models the collisions of heavy particles, and the Particle-In-Cell method models the transport of ions in an electric field. The accuracy of the simulation is assessed through comparison with various sets of measured data. It is found that a magnetic field significantly affects the profile of the plasma in the Detailed model. For instance, the plasma potential decreases more rapidly with distance from the thruster in the presence of a magnetic field. Results predicted by the Detailed model with the magnetic field are in better agreement with experimental data than those obtained with other models investigated.Ph.D.Aerospace EngineeringUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttp://deepblue.lib.umich.edu/bitstream/2027.42/60648/1/astron_1.pd

Negative Affect and Counterproductive Work Behavior: Roles of Arousal Level

Negative affect is examined for its influences on counterproductive work behavior (CWB) aimed at individuals (CWBI) or organizations (CWBO). The circumplex model of affect is applied to a sample of 264 employees in South Korea. Results support the predictions that high arousal negative affect is positively associated with CWBI and low arousal negative affect is positively associated with CWBO. Limitations and implications are discussed.This Study was supported by the Institute of Management Research at Seoul National Universit

A machine learning approach to discover migration modes and transition dynamics of heterogeneous dendritic cells

Dendritic cell (DC) migration is crucial for mounting immune responses. Immature DCs (imDCs) reportedly sense infections, while mature DCs (mDCs) move quickly to lymph nodes to deliver antigens to T cells. However, their highly heterogeneous and complex innate motility remains elusive. Here, we used an unsupervised machine learning (ML) approach to analyze long-term, two-dimensional migration trajectories of Granulocyte-macrophage colony-stimulating factor (GMCSF)-derived bone marrow-derived DCs (BMDCs). We discovered three migratory modes independent of the cell state: slow-diffusive (SD), slow-persistent (SP), and fast-persistent (FP). Remarkably, imDCs more frequently changed their modes, predominantly following a unicyclic SD→FP→SP→SD transition, whereas mDCs showed no transition directionality. We report that DC migration exhibits a history-dependent mode transition and maturation-dependent motility changes are emergent properties of the dynamic switching of the three migratory modes. Our ML-based investigation provides new insights into studying complex cellular migratory behavior

Dendritic Cell Migration Is Tuned by Mechanical Stiffness of the Confining Space

The coordination of cell migration of immune cells is a critical aspect of the immune response to pathogens. Dendritic cells (DCs), the sentinels of the immune system, are exposed to complex tissue microenvironments with a wide range of stiffnesses. Recent studies have revealed the importance of mechanical cues in immune cell trafficking in confined 3D environments. However, the mechanism by which stiffness modulates the intrinsic motility of immature DCs remains poorly understood. Here, immature DCs were found to navigate confined spaces in a rapid and persistent manner, surveying a wide range when covered with compliant gels mimicking soft tissues. However, the speed and persistence time of random motility were both decreased by confinement in gels with higher stiffness, mimicking skin or diseased, fibrotic tissue. The impact of stiffness of surrounding tissue is crucial because most in vitro studies to date have been based on cellular locomotion when confined by microfabricated polydimethylsiloxane structures. Our study provides evidence for a role for environmental mechanical stiffness in the surveillance strategy of immature DCs in tissues

A microfluidic chip for screening individual cancer cells via eavesdropping on autophagyinducing crosstalk in the stroma niche

Autophagy is a cellular homeostatic mechanism where proteins and organelles are digested and recycled to provide an alternative source of building blocks and energy to cells. The role of autophagy in cancer microenvironment is still poorly understood. Here, we present a microfluidic system allowing monitoring of the crosstalk between single cells. We used this system to study how tumor cells induced autophagy in the stromal niche. Firstly, we could confirm that transforming growth factor beta 1 (TGF beta 1) secreted from breast tumor cells is a paracrine mediator of tumor-stroma interaction leading to the activation of autophagy in the stroma component fibroblasts. Through proof of concept experiments using TGF beta 1 as a model factor, we could demonstrate real time monitoring of autophagy induction in fibroblasts by single tumor cells. Retrieval of individual tumor cells from the microfluidic system and their subsequent genomic analysis was possible, allowing us to determine the nature of the factor mediating tumor-stroma interactions. Therefore, our microfluidic platform might be used as a promising tool for quantitative investigation of tumor-stroma interactions, especially for and high-throughput screening of paracrine factors that are secreted from heterogeneous tumor cell populations

Effects of dietary supplementation with fermented and non-fermented brown algae by-products on laying performance, egg quality, and blood profile in laying hens

Objective This study was conducted to investigate the effects of dietary supplementation with fermented and non-fermented brown algae by-products on the laying performance, egg quality, relative organ weight, and blood profile of laying hens. Methods Hy-Line Brown chickens (n = 180; 70-week-old) were randomly divided into 5 groups with 4 replicates per group (3 hens per cage, 4 cages per replicate), and fed with 5 experimental diets, namely the basal control diet (CON) or the control diet supplemented with 0.5% brown seaweed (BS), 0.5% seaweed fusiforme (SF), 0.5% fermented brown seaweed (FBS), or 0.5% fermented seaweed fusiforme (FSF), for 4 weeks. Results Egg production rate and egg mass were greater in the BS group than in the other groups (p<0.05), and the SF and FSF groups had greater egg production than the control group (p<0.05). Egg weight was higher in the BS group than in the other groups (p<0.05). There were no differences in eggshell color, egg yolk color, eggshell strength, or eggshell thickness among the groups. There was no difference in Haugh units among the treatment groups, except for the FSF group, which had a significantly lower value (p<0.05). The non-fermented groups had greater relative organ weights, particularly the liver and cecum, than the other groups (p<0.05). Regarding blood profile, the supplemented-diet groups had higher albumin levels than the control group (p<0.05). The FBS group had higher total cholesterol and triglyceride levels than the other groups (p<0.05). The BS and FBS groups had higher glutamic pyruvic transaminase levels than the other groups (p<0.05). Conclusion This study demonstrated that dietary brown algae supplementation can improve egg-laying performance; however, supplementation with fermented seaweeds had no positive effect on the egg-laying performance of hens

Capacity of Wood as Flooring Material: Improvement of Thermal Performance of Wood/Phase Change Material Composites

Wood is a biomaterial with good carbon fixation capacity. Phase change materials (PCMs) can impart thermal storage performances to materials. The goal of this study is to improve thermal performance by impregnating PCM into porous wood. The chemical stability of the composites was analyzed to evaluate whether it was appropriate for PCM to be impregnated into wood. Thermal performance of the composites was evaluated through latent heat analysis and thermal conductivity analysis. As a result of the analysis, the composites showed improved thermal performance compared to pure wood. In addition, in order to evaluate the applicability of the composites for floor heating, the dynamic heat transfer test was conducted using specimens as flooring material. As a result, it was confirmed that room temperature maintained the indoor comfort temperature range for longer time in rooms where composite specimens were applied as floor material. Result suggests that the composites can reduce the time for operating heating energy for floor heating. Thus, composites produced in this study proved to have the potential to be used as floor finishing material for floor radiant heating systems

Particle Simulation of Plume Flows from an Anode-Layer Hall Thruster

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/76848/1/AIAA-28384-370.pd