Lasiodiplodins from mangrove endophytic fungus <i>Lasiodiplodia</i> sp. 318#

<p>Four new lasiodiplodins (<b>1</b>–<b>4</b>), together with three known analogues, have been isolated from a mangrove endophytic fungus, <i>Lasiodiplodia</i> sp. 318#. Their structures were elucidated by spectroscopic techniques. Cytotoxic activities of compounds <b>1</b>–<b>7</b> were evaluated in vitro against human cancer lines THP1, MDA-MB-435, A549, HepG2 and HCT-116. Compound <b>4</b> exhibited moderate cytotoxic activities.</p

α-Glucosidase inhibitory and cytotoxic botryorhodines from mangrove endophytic fungus <i>Trichoderma</i> sp. 307

<p>One new depsidone, botryorhodine H (<b>1</b>), together with three known analogues, botryorhodines C, D and G (<b>2</b>–<b>4</b>), were obtained from the mangrove endophytic fungus <i>Trichoderma</i> sp. 307 by co-culturing with <i>Acinetobacter johnsonii</i> B2. Structures were determined by 1D and 2D NMR analyses and high-resolution mass spectrum. Compounds <b>1</b>–<b>3</b> showed α-glucosidase inhibitory activity with IC₅₀ ranging from 8.1 to 11.2 μM, and compound <b>1</b> exhibited potent cytotoxicity against rat prolactinoma MMQ and rat pituitary adenoma GH3 cell lines (IC₅₀ = 3.09 and 3.64 μM).</p

Asperterpenols A and B, New Sesterterpenoids Isolated from a Mangrove Endophytic Fungus <i>Aspergillus</i> sp. 085242

Asperterpenol A (<b>1</b>) and asperterpenol B (<b>2</b>), two novel sesterterpenoids with an unusual 5/8/6/6 tetracyclic ring skeleton, were isolated from a mangrove endophytic fungus <i>Aspergillus</i> sp. 085242. The structures were elucidated on the basis of spectroscopic methods and the absolute configurations determined by single-crystal X-ray diffraction analysis. Compounds <b>1</b> and <b>2</b> inhibit acetylcholinesterase with IC₅₀ values of 2.3 and 3.0 μM, respectively

Asperterpenols A and B, New Sesterterpenoids Isolated from a Mangrove Endophytic Fungus <i>Aspergillus</i> sp. 085242

Asperterpenol A (<b>1</b>) and asperterpenol B (<b>2</b>), two novel sesterterpenoids with an unusual 5/8/6/6 tetracyclic ring skeleton, were isolated from a mangrove endophytic fungus <i>Aspergillus</i> sp. 085242. The structures were elucidated on the basis of spectroscopic methods and the absolute configurations determined by single-crystal X-ray diffraction analysis. Compounds <b>1</b> and <b>2</b> inhibit acetylcholinesterase with IC₅₀ values of 2.3 and 3.0 μM, respectively

Asperterpenols A and B, New Sesterterpenoids Isolated from a Mangrove Endophytic Fungus <i>Aspergillus</i> sp. 085242

Asperterpenol A (<b>1</b>) and asperterpenol B (<b>2</b>), two novel sesterterpenoids with an unusual 5/8/6/6 tetracyclic ring skeleton, were isolated from a mangrove endophytic fungus <i>Aspergillus</i> sp. 085242. The structures were elucidated on the basis of spectroscopic methods and the absolute configurations determined by single-crystal X-ray diffraction analysis. Compounds <b>1</b> and <b>2</b> inhibit acetylcholinesterase with IC₅₀ values of 2.3 and 3.0 μM, respectively

Asperterpenoid A, a New Sesterterpenoid as an Inhibitor of <i>Mycobacterium tuberculosi</i>s Protein Tyrosine Phosphatase B from the Culture of <i>Aspergillus</i> sp. 16-5c

Asperterpenoid A (<b>1</b>), a novel sesterterpenoid with a new carbon skeleton, has been isolated from a mangrove endophytic fungus <i>Aspergillus</i> sp. 16-5c. Its structure was characterized by extensive spectroscopic methods, and the absolute configuration was determined by single crystal X-ray diffraction analysis. Asperterpenoid A (<b>1</b>) exhibited strong inhibitory activity against <i>Mycobacterium tuberculosis</i> protein tyrosine phosphatase B (<i>m</i>PTPB) with an IC₅₀ value of 2.2 μM

Aspterpenacids A and B, Two Sesterterpenoids from a Mangrove Endophytic Fungus Aspergillus terreus H010

Two new sesterterpenoids, aspterpenacids A (<b>1</b>) and B (<b>2</b>), with an unusual carbon skeleton of a 5/3/7/6/5 ring system were isolated from the mangrove endophytic fungus Aspergillus terreus H010. Their structures were elucidated on the basis of spectroscopic methods, single-crystal X-ray diffraction analysis, and electronic circular dichroism calculations. A biogenetic pathway for <b>1</b> and <b>2</b> is proposed. Both <b>1</b> and <b>2</b> showed no significant antibacterial activity or cytotoxicity at 50 μM

Aspterpenacids A and B, Two Sesterterpenoids from a Mangrove Endophytic Fungus Aspergillus terreus H010

Two new sesterterpenoids, aspterpenacids A (<b>1</b>) and B (<b>2</b>), with an unusual carbon skeleton of a 5/3/7/6/5 ring system were isolated from the mangrove endophytic fungus Aspergillus terreus H010. Their structures were elucidated on the basis of spectroscopic methods, single-crystal X-ray diffraction analysis, and electronic circular dichroism calculations. A biogenetic pathway for <b>1</b> and <b>2</b> is proposed. Both <b>1</b> and <b>2</b> showed no significant antibacterial activity or cytotoxicity at 50 μM

New lasiodiplodins from mangrove endophytic fungus <i>Lasiodiplodia</i> sp. 318^#

<p>Two new lasiodiplodins (<b>1</b>–<b>2</b>) together with three known analogues, were isolated from a mangrove endophytic fungus, <i>Lasiodiplodia</i> sp. 318^#. Their structures were established by spectroscopic techniques (1D- and 2D-NMR, HR-ESI-MS, etc.), and electronic circular dichroism. Cytotoxic activities of compounds <b>1</b>–<b>5</b> were evaluated <i>in vitro</i>. Compound <b>4</b> was the most potent, with IC₅₀ values of 5.29 μM against MMQ, 13.05 μM against GH3. Preliminary structural-activity analysis indicated that the functional group (resorcinol-3-OH) contributed greatly to the binding of Lasiodiplodins to the cytotoxic activities.</p