<p>Four new lasiodiplodins (<b>1</b>–<b>4</b>), together with three known analogues, have been isolated from a mangrove endophytic fungus, <i>Lasiodiplodia</i> sp. 318#. Their structures were elucidated by spectroscopic techniques. Cytotoxic activities of compounds <b>1</b>–<b>7</b> were evaluated in vitro against human cancer lines THP1, MDA-MB-435, A549, HepG2 and HCT-116. Compound <b>4</b> exhibited moderate cytotoxic activities.</p
