IJTC2009-15084 THE STATIC CHARACTERISTICS OF BUMP FOIL THRUST BEARING CONSIDERING TILTING CONDITION

ABSTRACT Air foil thrust bearings are the critical component available on high-efficiency turbomachinery which needs ability to endure the large axial force. Previous investigations about the static characteristics were obtained over the region of the thin air film using finite-difference method and the characteristics of the corrugated bump foil using finite-element method. Moreover, a recent study demonstrated that bearing performance is sensitive to tilting thrust pad condition

Clinical characteristics of 2009 pandemic influenza A (H1N1) infection in children and the performance of rapid antigen test

PurposeIn autumn 2009, the swine-origin influenza A (H1N1) virus spread throughout South Korea. The aims of this study were to determine the clinical characteristics of children infected by the 2009 H1N1 influenza A virus, and to compare the rapid antigen and real-time polymerase chain reaction (PCR) tests.MethodsWe conducted a retrospective review of patients ≥18 years of age who presented to Soonchunhyang University Hospital in Seoul with respiratory symptoms, including fever, between September 2009 and January 2010. A real-time PCR test was used to definitively diagnose 2009 H1N1 influenza A infection. Medical records of confirmed cases were reviewed for sex, age, and the time of infection. The decision to perform rapid antigen testing was not influenced by clinical conditions, but by individual factors such as economic conditions. Its sensitivity and specificity were evaluated compared to real-time PCR test results.ResultsIn total, 934 patients tested positive for H1N1 by real-time PCR. The highest number of patients (48.9%) was diagnosed in November. Most patients (48.2%) were aged between 6 and 10 years. Compared with the H1N1 real-time PCR test results, the rapid antigen test showed 22% sensitivity and 83% specificity. Seventy-eight patients were hospitalized for H1N1 influenza A virus infection, and fever was the most common symptom (97.4%).ConclusionFor diagnosis of 2009 H1N1 influenza A virus infection, the rapid antigen test was inferior to the real-time PCR test in both sensitivity and specificity. This outcome suggests that the rapid antigen test is inappropriate for screening

AAD-2004, a potent spin trapping molecule and microsomal prostaglandin E synthase-1 inhibitor, shows safety and efficacy in a mouse model of ALS

While free radicals and inflammation constitute major routes of neuronal injury occurring in neurodegenerative diseases, neither antioxidants nor nonsteroidal anti-inflammatory drugs (NSAIDs) have shown significant efficacy in human clinical trials. To explore the possibility that concurrent blockade of free radicals and PGE2-mediated inflammation might constitute a safe and effective therapeutic approach to certain neurodegenerative diseases, we have developed 2-hydroxy-5-[2-(4-trifluoromethylphenyl)-ethylaminobezoic acid (AAD-2004) as a derivative of aspirin. AAD-2004 completely removed free radicals at 50 nM as a potent spin trapping molecule and inhibited microsomal prostaglandin E synthase-1 (mPGES-1) with an IC50 of 230 nM. Oral administration of AAD-2004 blocked free radical formation, PGE2 formation, and microglial activation in the spinal motor neurons of SOD1G93A mice. As a consequence, AAD-2004 reduced autophagosome formation, axonopathy, and motor neuron degeneration, improving motor function and increasing life span. In these assays, AAD-2004 was superior to ibuprofen or riluzole. Gastric bleeding was not induced by AAD-2004 even at a dose 400-fold higher than that required to obtain maximal therapeutic efficacy in SOD1G93A mice. Targeting both mPGES-1 and free radicals may be a promising approach to reduce neurodegeneration in ALS and possibly other neurodegenerative diseases

STATIC AND DYNAMIC CHARACTERISTICS OF AIR FOIL THRUST BEARING CONSIDERING TILTING PAD CONDITION

ABSTRACT The thrust pad of the rotor is used to sustain the axial force generated due to the pressure difference between the compressor and turbine sides of turbomachinery such as the gas turbines and turbochargers. Furthermore, this thrust pad has a role to maintain and determines the attitude of the rotor. In a real system, it also helps reinforce the stiffness and damping of the journal bearing. This study was performed for the purpose of analyzing the characteristics of the air foil thrust bearing. The model for the air foil thrust bearing used in this study is composed of two parts: one is an inclined plane, which plays a role to increase the load carrying capacity using the physical wedge effect, and the other is a flat plane. This study mainly consists of three parts. First, the static characteristics were obtained over the region of the thin air film using the finite difference method (FDM) and the bump foil characteristics using the finite element method (FEM). Second, the analysis of the dynamic characteristics was conducted by perturbation method. For more exact calculation, the rarefaction gas coefficients perturbed about the pressure and film thickness were taken into consideration. At last, the static and dynamic characteristics of the tilting condition of the thrust pad were obtained. Furthermore, the load carrying capacity and torque were calculated for both tilting and not-tilting conditions. From this study, several results were presented: 1) the stiffness and damping of the bump foil under the condition of the various bump parameters, 2) the load carrying capacity and bearing torque at the tilting state, 3) the bearing performance under various bearing parameters, 4) the effects considering the rarefaction gas coefficients

Heteroepitaxal fabrication and structural characterization of ultrafine GaN/ZnO coaxial nanorod heterostructures

We report on heteroepitaxial fabrication and structural characterizations of ultrafine GaN/ZnO coaxial nanorod heterostructures. The coaxial nanorod heterostructures were fabricated by epitaxial growth of a GaN layer on ultrafine ZnO nanorods. Epitaxial growth and precise control of GaN overlayer thickness were obtained by low pressure metalorganic vapor-phase epitaxy. ZnO nanorods grown on Si and sapphire substrates using catalyst-free metalorganic chemical vapor deposition exhibited diameters as small as 7 nm. Furthermore, structural properties of the coaxial nanorod heterostructures were investigated using both synchrotron-radiation x-ray diffraction and high resolution transmission electron microscopy. (C) 2004 American Institute of Physics