Automatic Labeled LiDAR Data Generation based on Precise Human Model

Following improvements in deep neural networks, state-of-the-art networks have been proposed for human recognition using point clouds captured by LiDAR. However, the performance of these networks strongly depends on the training data. An issue with collecting training data is labeling. Labeling by humans is necessary to obtain the ground truth label; however, labeling requires huge costs. Therefore, we propose an automatic labeled data generation pipeline, for which we can change any parameters or data generation environments. Our approach uses a human model named Dhaiba and a background of Miraikan and consequently generated realistic artificial data. We present 500k+ data generated by the proposed pipeline. This paper also describes the specification of the pipeline and data details with evaluations of various approaches.Comment: Accepted at ICRA201

Molecular mechanisms of microtubule-dependent kinetochore transport toward spindle poles

In mitosis, kinetochores are initially captured by the lateral sides of single microtubules and are subsequently transported toward spindle poles. Mechanisms for kinetochore transport are not yet known. We present two mechanisms involved in microtubule-dependent poleward kinetochore transport in Saccharomyces cerevisiae. First, kinetochores slide along the microtubule lateral surface, which is mainly and probably exclusively driven by Kar3, a kinesin-14 family member that localizes at kinetochores. Second, kinetochores are tethered at the microtubule distal ends and pulled poleward as microtubules shrink (end-on pulling). Kinetochore sliding is often converted to end-on pulling, enabling more processive transport, but the opposite conversion is rare. The establishment of end-on pulling is partly hindered by Kar3, and its progression requires the Dam1 complex. We suggest that the Dam1 complexes, which probably encircle a single microtubule, can convert microtubule depolymerization into the poleward kinetochore-pulling force. Thus, microtubule-dependent poleward kinetochore transport is ensured by at least two distinct mechanisms

An Adaptive Two-Stage Dose-Response Design Method for Establishing Proof of Concept in Drug Development

In clinical drug development, searching for the true dose-response curve is ethically and logistically challenging. Establishing evidence of dose-response or Proof of Concept (PoC) is the first step for both determining the best dose-response model and optimizing a treatment dose correctly for clinical use. To overcome these challenges, we employ an adaptive two-stage design where both adding and dropping treatment arms is possible between stages. In the first part of this dissertation, we develop a method extending the Multiple Comparison Procedures and Modeling (MCP-Mod) approach into this adaptive two-stage design. Our goal is to establish "global" PoC across the stages. Between stages, we propose using an Adding and/or Dropping Treatment Adaptation Rule (ADTAR). In the ADTAR method, dose specifications in the second stage depend on the first stage's results. Treating the unobserved doses and imbalanced aggregate sample sizes in the second stage as missing data, we derive weights and adjust the test statistics in the second stage. Specifically, we assume that the missing data mechanism caused by ADTAR is missing at random. At the end of the second stage, we perform the global PoC test combining the test results from both stages. To preserve the family-wise error rate, we use a Conditional Error Function. Using simulation studies, we evaluated our design method and compared it to a conventional (one-stage) study design and different fixed two-stage designs. Our method showed overall robust high power for detecting the global PoC across three forms of true dose-response curves. In the second part of this dissertation, we find constraints for choosing doses in the original and extended MCP-Mod methods. Specifically, we establish lower bounds of the number and levels of doses for each method using simulation studies. Our proposed method is a viable tool in searching for a dose-response relationship. In accordance with ICH guidelines, our method helps to provide optimal doses of drugs for treating or preventing different diseases. Since drugs are widely used in human populations, such methods have a great Public Health impact in appropriately treating or preventing many types of diseases

Culture Mediator Model as a Predictor for Somatic Complaints among Japanese and Japanese Americans

[Abstract Not Included

Search for the Infrared Emission Features from Deuterated Interstellar Polycyclic Aromatic Hydrocarbons

We report the results of a search for emission features from interstellar deuterated polycyclic aromatic hydrocarbons (PAHs) in the 4um region with the Infrared Camera (IRC) onboard AKARI. No significant excess emission is seen in 4.3-4.7um in the spectra toward the Orion Bar and M17 after the subtraction of line emission from the ionized gas. A small excess of emission remains at around 4.4 and 4.65um, but the ratio of their intensity to that of the band emission from PAHs at 3.3-3.5um is estimated as 2-3%. This is an order of magnitude smaller than the values previously reported and also those predicted by the model of deuterium depletion onto PAHs. Since the subtraction of the ionized gas emission introduces an uncertainty, the deuterated PAH features are also searched for in the reflection nebula GN 18.14.0, which does not show emission lines from ionized gas. We obtain a similar result that excess emission in the 4um region, if present, is about 2% of the PAH band emission in the 3um region. The present study does not find evidence for the presence of the large amount of deuterated PAHs that the depletion model predicts. The results are discussed in the context of deuterium depletion in the interstellar medium.Comment: 24 pages, 6 figures, to appear in Ap

Hemodynamic impact of ephedrine on hypotension during general anesthesia : a prospective cohort study on middle-aged and older patients

Background Ephedrine is a mixed α- and β-agonist vasopressor that is frequently used for the correction of hypotension during general anesthesia. β-responsiveness has been shown to decrease with age; therefore, this study aimed to determine whether aging would reduce the pressor effect of ephedrine on hypotension during general anesthesia. Methods Seventy-five patients aged ≥ 45 years were included in this study, with 25 patients allocated to each of the three age groups: 45–64 years, 65–74 years, and ≥ 75 years. All patients received propofol, remifentanil, and rocuronium for the induction of general anesthesia, followed by desflurane and remifentanil. Cardiac output (CO) was estimated using esCCO technology. Ephedrine (0.1 mg/kg) was administered for the correction of hypotension. The primary and secondary outcome measures were changes in the mean arterial pressure (MAP) and CO, respectively, at 5 min after the administration of ephedrine. Results The administration of ephedrine significantly increased MAP (p < 0.001, mean difference: 8.34 [95% confidence interval (CI), 5.95–10.75] mmHg) and CO (p < 0.001, mean difference: 7.43 [95% CI, 5.20–9.65] %) across all groups. However, analysis of variance revealed that the degree of elevation of MAP (F [2, 72] = 0.546, p = 0.581, η2 = 0.015 [95% CI, 0.000–0.089]) and CO (F [2, 72] = 2.023, p = 0.140, η2 = 0.053 [95% CI, 0.000–0.162]) did not differ significantly among the groups. Similarly, Spearman’s rank correlation and multiple regression analysis revealed no significant relation between age and the changes in MAP or CO after the administration of ephedrine. Conclusion The administration of ephedrine significantly increased MAP and CO; however, no significant correlation with age was observed in patients aged > 45 years. These findings suggest that ephedrine is effective for the correction of hypotension during general anesthesia, even in elderly patients

Anesthetic management of a patient with mandibular hypoplasia, deafness, progeroid features, lipodystrophy syndrome : a case report

Background: Mandibular hypoplasia, deafness, progeroid features, and lipodystrophy (MDPL) syndrome is a rare autosomal dominant disorder that presents unique challenges for anesthetic management due to its multisystemic manifestations. This report outlines the anesthetic considerations for MDPL patients based on our case experience. Case presentation: A 15-year-old male with MDPL syndrome underwent testicular extraction under general anesthesia. Insertion of a peripheral venous catheter was challenging due to scleroderma-like skin. Although the facial features of MDPL syndrome suggested a difficult airway, intubation with a McGrath™ Mac video laryngoscope was successful. Despite MDPL syndrome’s association with hypertriglyceridemia due to lipodystrophy, this patient’s triglyceride levels were normal. Thiamylal and sevoflurane were used without issues such as delayed emergence from anesthesia. Conclusions: MDPL syndrome requires careful preoperative assessment and tailored anesthetic management due to potential airway challenges arising from its distinctive facial features and the possibility of altered anesthetic pharmacokinetics associated with lipodystrophy