Purification and complete amino acid sequence of canine pancreatic secretory trypsin inhibitor

AbstractPancreatic secretory trypsin inhibitor (PSTI) was purified from canine pancreatic juice by HPLC. Canine PSTI inhibited bovine trypsin activity stoichiometrically and strongly with a dissociation constant of below 10−9 M. The amino acid sequence of canine PSTI was determined by conventional methods. It had one more amino acid residue at the amino-terminus than other mammalian PSTIs, i.e. human, porcine, bovine and ovine

Porous Plug Phase Separator and Superfluid Film Flow Suppression System for the Soft X-Ray Spectrometer Onboard Hitomi

When using superfluid helium in low gravity environments, porous plug phase separators are commonly used to vent boiloff gas while confining the bulk liquid to the tank. Invariably, there is a flow of superfluid film from the perimeter of the porous plug down the vent line. For the Soft X-ray Spectrometer onboard ASTRO-H (Hitomi), its approximately 30-liter helium supply has a lifetime requirement of more than 3 years. A nominal vent rate is estimated as ~ 30 ug/s, equivalent to ~ 0.7 mW heat load. It is therefore critical to suppress any film flow whose evaporation would not provide direct cooling of the remaining liquid helium. That is, the porous plug vent system must be designed to both minimize film flow and to ensure maximum extraction of latent heat from the film. The design goal for Hitomi is to reduce the film flow losses to <2 ug/s, corresponding to a loss of cooling capacity of <40 uW. The design adopts the same general design as implemented for Astro-E and E2, using a vent system composed of a porous plug, combined with an orifice, a heat exchanger, and knife-edge devices. In this paper, design, on-ground testing results and in-orbit performance are described

The ASTRO-H X-ray Observatory

The joint JAXA/NASA ASTRO-H mission is the sixth in a series of highly successful X-ray missions initiated by the Institute of Space and Astronautical Science (ISAS). ASTRO-H will investigate the physics of the high-energy universe via a suite of four instruments, covering a very wide energy range, from 0.3 keV to 600 keV. These instruments include a high-resolution, high-throughput spectrometer sensitive over 0.3-2 keV with high spectral resolution of Delta E < 7 eV, enabled by a micro-calorimeter array located in the focal plane of thin-foil X-ray optics; hard X-ray imaging spectrometers covering 5-80 keV, located in the focal plane of multilayer-coated, focusing hard X-ray mirrors; a wide-field imaging spectrometer sensitive over 0.4-12 keV, with an X-ray CCD camera in the focal plane of a soft X-ray telescope; and a non-focusing Compton-camera type soft gamma-ray detector, sensitive in the 40-600 keV band. The simultaneous broad bandpass, coupled with high spectral resolution, will enable the pursuit of a wide variety of important science themes.Comment: 22 pages, 17 figures, Proceedings of the SPIE Astronomical Instrumentation "Space Telescopes and Instrumentation 2012: Ultraviolet to Gamma Ray

Highly active BaTi4O9/RuO2 photocatalyst by polymerized complex method

科研費報告書収録論文(課題番号:08455403・基盤研究(B)(2)・H8～H10/研究代表者:佐藤, 次雄/眉間包接半導体擬似分子の創製と光化学特性

A CASE OF OCCULT ECTOPIC CORTICOTROPIN (ACTH) SYNDROME MAITAINING REMISSION STATE OVER 4 YEARS AFTER BILATERAL ADRENALECTOMY

A long-lasting state of remission of over 4 years of occult ectopic cor- ticotropin (ACTH) syndrome in a 68-year-old female is reported. She presented with general malaise, muscle atrophy and weakness of extremities, general petechiae and hypokalemia. Although ectopic ACTH syndrome was suspected due to marked hypercor- tisolism and ACTH elevation, the source of ACTH secretion could not detected by any diagnostic technique. Because of that effective suppression of plasma cortisol levels by torilostane, a 3 β-hydroxy-steroid-dehydrogenase inhibitor, could not obtained, so bilateral adrenalectomy was performed. After the operation, supplemental therapy of hydrocor- tisone and Florinef, 9 α-fluorohydrocortisone, was initiated and the plasma ACTH levels decreased gradually. At the 6th postoperative month, the levels of ACTH remained within the normal range and her general status markedly improved. At the 4th postoperative year, the plasma ACTH still maintained normal levels with no recurrence. Cases of occult ectopic ACTH syndrome which remain in remission for a long period after bilateral adrenalectomy are rare and interesting. Bilateral adrenalectomy may be the first choice of treatment for occult ectopic ACTH syndrome with the support of chemical therapy