Financial transactions tax : panacea, threat, or damp squib ?

Attempts to raise a significant percentage of gross domestic product in revenue from a broad-based financial transactions tax are likely to fail both by raising much less revenue than expected and by generating far-reaching changes in economic behavior. Although the side-effects would include a sizable restructuring of financial sector activity, this would not occur in ways corrective of the particular forms of financial overtrading that were most conspicuous in contributing to the crisis.Debt Markets,Emerging Markets,Taxation&Subsidies,Banks&Banking Reform,Economic Theory&Research

Online Versus In-person Mathematics Instruction: A Comparison of Two Instructional Models

Our paper explores the differences between online and traditional, in-person teaching and learning modalities, looking specifically at courses preparing teachers to be mathematics teacher leaders. In the context of current research on the teaching and learning of mathematics in an online setting, we share our own experiences. We describe the preparation for and teaching of online mathematics, focusing on establishing norms and the use of technology. The changing teaching and learning opportunities of the 21st century require discussion of these vital issues. We include stories of interactions between candidates and teachers and among groups of candidates in mathematics courses, detailing not just the discursive and work-sharing tools but the nature and nuance of these interactions and how they mediate mathematics learning. We share our online teaching and learning experiences, drawing on research to frame our impressions. By identifying key similarities and differences between instructional modalities and by reflecting critically on our own successes and challenges, we present a vision of online teaching and learning for mathematics courses, in particular those for mathematics specialists, that can be effective, inclusive, and relational

Deletion of airway cilia results in noninflammatory bronchiectasis and hyperreactive airways

The mechanisms for the development of bronchiectasis and airway hyperreactivity have not been fully elucidated. Although genetic, acquired diseases and environmental influences may play a role, it is also possible that motile cilia can influence this disease process. We hypothesized that deletion of a key intraflagellar transport molecule, IFT88, in mature mice causes loss of cilia, resulting in airway remodeling. Airway cilia were deleted by knockout of IFT88, and airway remodeling and pulmonary function were evaluated. In IFT88− mice there was a substantial loss of airway cilia on respiratory epithelium. Three months after the deletion of cilia, there was clear evidence for bronchial remodeling that was not associated with inflammation or apparent defects in mucus clearance. There was evidence for airway epithelial cell hypertrophy and hyperplasia. IFT88− mice exhibited increased airway reactivity to a methacholine challenge and decreased ciliary beat frequency in the few remaining cells that possessed cilia. With deletion of respiratory cilia there was a marked increase in the number of club cells as seen by scanning electron microscopy. We suggest that airway remodeling may be exacerbated by the presence of club cells, since these cells are involved in airway repair. Club cells may be prevented from differentiating into respiratory epithelial cells because of a lack of IFT88 protein that is necessary to form a single nonmotile cilium. This monocilium is a prerequisite for these progenitor cells to transition into respiratory epithelial cells. In conclusion, motile cilia may play an important role in controlling airway structure and function

The effect of summertime shelf break upwelling on nutrient flux in southeastern United States continental shelf waters

Gulf Stream-induced upwelling at the shelf break of the South Atlantic Bight (SAB) presents water which, in summer, can intrude onto the continental shelf. In July 1979, an XBT survey of the continental shelf revealed such an intrusion of cold water off St. Augustine, Florida. From weekly mappings, it was determined that Gulf Stream water \u3c22.5°C covered 3280 km2 and occupied 38 km3 shoreward of the 42 m isobath. Using temperature and nitrate distributions and the T°C:NO3 relationship, we determined that 3200 metric tons of nitrate-nitrogen were advected into the study area. Net nitrate-nitrogen fluxes were 32 μmoles · m−2 · sec−1 across the 42 m isobath and 30 μmoles · m−2 · sec−1 across the 30 m isobath.The advection of nitrate-enriched water into the photic zone caused a dramatic increase in phytoplankton biomass. The decreasing nitrate concentrations correlated with chlorophyll increases indicating phytoplankton production was mainly at the expense of nitrate advected into the area. Prior to the intrusion, production was likely supported by regenerated nutrients.Summertime intrusions supply an estimated 2.9 × 104 mtons NO3-N · yr−1 to the middle shelf area of the southern SAB and are thus a major source of nitrogen to that area

U.S. Billion-ton Update: Biomass Supply for a Bioenergy and Bioproducts Industry

The Report, Biomass as Feedstock for a Bioenergy and Bioproducts Industry: The Technical Feasibility of a Billion-Ton Annual Supply (generally referred to as the Billion-Ton Study or 2005 BTS), was an estimate of “potential” biomass within the contiguous United States based on numerous assumptions about current and future inventory and production capacity, availability, and technology. In the 2005 BTS, a strategic analysis was undertaken to determine if U.S. agriculture and forest resources have the capability to potentially produce at least one billion dry tons of biomass annually, in a sustainable manner—enough to displace approximately 30% of the country’s present petroleum consumption. To ensure reasonable confidence in the study results, an effort was made to use relatively conservative assumptions. However, for both agriculture and forestry, the resource potential was not restricted by price. That is, all identified biomass was potentially available, even though some potential feedstock would more than likely be too expensive to actually be economically available. In addition to updating the 2005 study, this report attempts to address a number of its shortcoming

High-threshold and low-overhead fault-tolerant quantum memory

Quantum error correction becomes a practical possibility only if the physical error rate is below a threshold value that depends on a particular quantum code, syndrome measurement circuit, and a decoding algorithm. Here we present an end-to-end quantum error correction protocol that implements fault-tolerant memory based on a family of LDPC codes with a high encoding rate that achieves an error threshold of $0.8\%$ for the standard circuit-based noise model. This is on par with the surface code which has remained an uncontested leader in terms of its high error threshold for nearly 20 years. The full syndrome measurement cycle for a length-$n$ code in our family requires $n$ ancillary qubits and a depth-7 circuit composed of nearest-neighbor CNOT gates. The required qubit connectivity is a degree-6 graph that consists of two edge-disjoint planar subgraphs. As a concrete example, we show that 12 logical qubits can be preserved for ten million syndrome cycles using 288 physical qubits in total, assuming the physical error rate of $0.1\%$. We argue that achieving the same level of error suppression on 12 logical qubits with the surface code would require more than 4000 physical qubits. Our findings bring demonstrations of a low-overhead fault-tolerant quantum memory within the reach of near-term quantum processors

Physiological and Perceived Effects of Forearm or Head Cooling During Simulated Firefighting Activity and Rehabilitation.

CONTEXT:  Cooling devices aim to protect firefighters by attenuating a rise in body temperature. Devices for head cooling (HC) while firefighting and forearm cooling (FC) during rehabilitation (RHB) intervals are commonly marketed, but research regarding their efficacy is limited. OBJECTIVE:  To investigate the physiological and perceived effects of HC and FC during firefighting drills and RHB. DESIGN:  Randomized controlled clinical trial. SETTING:  Firefighter training center. PATIENTS OR OTHER PARTICIPANTS:  Twenty-seven male career firefighters (age = 39 ± 7 years; height = 169 ± 7 cm; weight = 95.4 ± 16.8 kg). INTERVENTION(S):  Firefighters were randomly assigned to 1 condition: HC (n = 9), in which participants completed drills wearing a cold gel pack inside their helmet; FC (n = 8), in which participants sat on a collapsible chair with water-immersion arm troughs during RHB; or control (n = 10), in which participants used no cooling devices. Firefighters completed four 15-minute drills (D1-D4) wearing full bunker gear and breathing apparatus. Participants had a 15-min RHB after D2 (RHB1) and D4 (RHB2). MAIN OUTCOME MEASURE(S):  Change (Δ) in gastrointestinal temperature (T RESULTS:  The T CONCLUSIONS:  The HC did not attenuate rises in physiological or perceptual variables during firefighting drills. The FC effectively reduced

CRISPR/Cas9 Genome Editing to Disable the Latent HIV-1 Provirus

HIV-1 infection can be successfully controlled with anti-retroviral therapy (ART), but is not cured. A reservoir of cells harboring transcriptionally silent integrated provirus is able to reestablish replicating infection if ART is stopped. Latently HIV-1 infected cells are rare, but may persist for decades. Several novel strategies have been proposed to reduce the latent reservoir, including DNA sequence targeted CRISPR/Cas9 genome editing of the HIV-1 provirus. A significant challenge to genome editing is the sequence diversity of HIV-1 quasispecies present in patients. The high level of quasispecies diversity will require targeting of multiple sites in the viral genome and personalized engineering of a CRISPR/Cas9 regimen. The challenges of CRISPR/Cas9 delivery to the rare latently infected cells and quasispecies sequence diversity suggest that effective genome editing of every provirus is unlikely. However, recent evidence from post-treatment controllers, patients with controlled HIV-1 viral burden following interruption of ART, suggests a correlation between a reduced number of intact proviral sequences and control of the virus. The possibility of reducing the intact proviral sequences in patients by a genome editing technology remains intriguing, but requires significant advances in delivery to infected cells and identification of effective target sites

Enhanced monography in a collaboratively evolved hub for systematic biology

No abstract available