Medicinal Plants in the Northwestern China and Their Medicinal Uses

The Northwestern China is a typical arid and semi-arid region of inner Asia, where some important medicinal species such as Angelica sinensis, Radix astragali, Radix codonopsis, Radix et rhizoma rhei, Radix glycyrrhizae, Lycium barbarum L are found and grew in the mountains areas, or desert areas. Among them, A. sinensis, R. astragali and R. glycyrrhizae are frequently used in traditional Chinese medicines and herbal prescriptions, thus encouraged many researchers to investigate and develop them. Our purpose is to provide a review of recent advances about three typical medicinal plants of A. sinensis, Astragalus membranaceus and R. glycyrrhizae in Northwestern China, mainly referring to botanical identity, chemical constituents, pharmacological studies, application in formulation, safety and cultivation practices. That will provide some valuable information for the further study and development of medicinal plants in Northwestern China

Tirofiban for Stroke without Large or Medium-Sized Vessel Occlusion

The effects of the glycoprotein IIb/IIIa receptor inhibitor tirofiban in patients with acute ischemic stroke but who have no evidence of complete occlusion of large or medium-sized vessels have not been extensively studied. In a multicenter trial in China, we enrolled patients with ischemic stroke without occlusion of large or medium-sized vessels and with a National Institutes of Health Stroke Scale score of 5 or more and at least one moderately to severely weak limb. Eligible patients had any of four clinical presentations: ineligible for thrombolysis or thrombectomy and within 24 hours after the patient was last known to be well; progression of stroke symptoms 24 to 96 hours after onset; early neurologic deterioration after thrombolysis; or thrombolysis with no improvement at 4 to 24 hours. Patients were assigned to receive intravenous tirofiban (plus oral placebo) or oral aspirin (100 mg per day, plus intravenous placebo) for 2 days; all patients then received oral aspirin until day 90. The primary efficacy end point was an excellent outcome, defined as a score of 0 or 1 on the modified Rankin scale (range, 0 [no symptoms] to 6 [death]) at 90 days. Secondary end points included functional independence at 90 days and a quality-of-life score. The primary safety end points were death and symptomatic intracranial hemorrhage. A total of 606 patients were assigned to the tirofiban group and 571 to the aspirin group. Most patients had small infarctions that were presumed to be atherosclerotic. The percentage of patients with a score of 0 or 1 on the modified Rankin scale at 90 days was 29.1% with tirofiban and 22.2% with aspirin (adjusted risk ratio, 1.26; 95% confidence interval, 1.04 to 1.53, P = 0.02). Results for secondary end points were generally not consistent with the results of the primary analysis. Mortality was similar in the two groups. The incidence of symptomatic intracranial hemorrhage was 1.0% in the tirofiban group and 0% in the aspirin group. In this trial involving heterogeneous groups of patients with stroke of recent onset or progression of stroke symptoms and nonoccluded large and medium-sized cerebral vessels, intravenous tirofiban was associated with a greater likelihood of an excellent outcome than low-dose aspirin. Incidences of intracranial hemorrhages were low but slightly higher with tirofiban

Construction and Method Study of the State of Charge Model for Lithium-Ion Packs in Electric Vehicles Using Ternary Lithium Packs as an Example

Accurate and real-time estimation of pack system-level chips is essential for the performance and reliability of future electric vehicles. Firstly, this study constructed a model of a nickel manganese cobalt cell on the ground of the electrochemical process of the packs. Then, it used methods on the grounds of the unscented Kalman filter and unscented Kalman particle filter for system-level chip estimation and algorithm construction. Both algorithms are on the ground of Kalman filters and can handle nonlinear and uncertain system states. In comparative testing, it can be seen that the unscented Kalman filter algorithm can accurately evaluate the system-level chip of the nickel manganese cobalt cell under intermittent discharge conditions. The system-level chip was 0.53 at 1000 s and was reduced to 0.45 at 1500 s. These results demonstrate that the evaluation of the ternary lithium battery pack’s performance is time-dependent and indicate the accuracy of the algorithm used during this time period. These data should be considered in the broader context of the study for a comprehensive understanding of their meaning. In the later stage, the estimation error of the recursive least-squares unscented Kalman particle filter method for system-level chips began to significantly increase, gradually exceeding 1%, with a corresponding root-mean-square error of 0.002171. This indicates that the recursive least-squares optimization algorithm, the unscented Kalman particle filter algorithm, diminished its root mean square error by 27.59%. The unscented Kalman filter and unscented Kalman particle filter are effective in estimating the system-level chip of nickel manganese cobalt cells. However, UPF performs more robustly in handling complex situations, such as pack aging and temperature changes. This study provides a new perspective and method that has a high reference value for pack management systems. This helps to achieve more effective energy management and improve pack life, thereby enhancing the reliability and practicality of electric vehicles

KELM: Knowledge Enhanced Pre-Trained Language Representations with Message Passing on Hierarchical Relational Graphs

Incorporating factual knowledge into pre-trained language models (PLM) such as BERT is an emerging trend in recent NLP studies. However, most of the existing methods combine the external knowledge integration module with a modified pre-training loss and re-implement the pre-training process on the large-scale corpus. Re-pretraining these models is usually resource-consuming, and difficult to adapt to another domain with a different knowledge graph (KG). Besides, those works either cannot embed knowledge context dynamically according to textual context or struggle with the knowledge ambiguity issue. In this paper, we propose a novel knowledge-aware language model framework based on fine-tuning process, which equips PLM with a unified knowledge-enhanced text graph that contains both text and multi-relational sub-graphs extracted from KG. We design a hierarchical relational-graph-based message passing mechanism, which can allow the representations of injected KG and text to mutually update each other and can dynamically select ambiguous mentioned entities that share the same text. Our empirical results show that our model can efficiently incorporate world knowledge from KGs into existing language models such as BERT, and achieve significant improvement on the machine reading comprehension (MRC) task compared with other knowledge-enhanced models.Comment: ICLR 2022 on DLG4NL

A Two Fiber Bragg Gratings Sensing System to Monitor the Torque of Rotating Shaft

By fixing two FBGs on the surface of a rotating shaft along the direction of ±45° and using dynamic wavelength demodulation technology, we propose an optical fiber sensing system to monitor the driving torque and torsion angle of the rotating shaft. In theory, the dependence relation of the dynamic difference of central wavelengths on the torque and torsion angle of the rotating shaft has been deduced. To verify an optical fiber sensing system, a series of sensing experiments have been completed and the measured data are approximately consistent with the theoretical analysis. The difference of two central wavelengths can be expressed as the sum of two parts: a “DC” part and a harmonic “AC” part. The driving torque or torsion angle is linear with the “DC” part of the difference of two central wavelengths, the harmonic “AC” part, meaning the torsion angle vibration, illustrates that periodic vibration torque may be caused by inhomogeneous centrifugal forces or inhomogeneous additional torques produced by the driving system and the load

Signal Processing for Time Domain Wavelengths of Ultra-Weak FBGs Array in Perimeter Security Monitoring Based on Spark Streaming

To detect perimeter intrusion accurately and quickly, a stream computing technology was used to improve real-time data processing in perimeter intrusion detection systems. Based on the traditional density-based spatial clustering of applications with noise (T-DBSCAN) algorithm, which depends on manual adjustments of neighborhood parameters, an adaptive parameters DBSCAN (AP-DBSCAN) method that can achieve unsupervised calculations was proposed. The proposed AP-DBSCAN method was implemented on a Spark Streaming platform to deal with the problems of data stream collection and real-time analysis, as well as judging and identifying the different types of intrusion. A number of sensing and processing experiments were finished and the experimental data indicated that the proposed AP-DBSCAN method on the Spark Streaming platform exhibited a fine calibration capacity for the adaptive parameters and the same accuracy as the T-DBSCAN method without the artificial setting of neighborhood parameters, in addition to achieving good performances in the perimeter intrusion detection systems