Research progress on bio-inspired flapping-wing rotor micro aerial vehicle development

Flapping-wing rotor (FWR) is an innovative bio-inspired micro aerial vehicle capable of vertical take-off and landing. This unique design combines active flapping motion and passive wing rotation around a vertical central shaft to enhance aerodynamic performance. The research on FWR, though relatively new, has contributed to 6% of core journal publications in the micro aerial vehicle field over the past two decades. This paper presents the first comprehensive review of FWR, analysing the current state of the art, key advances, challenges, and future research directions. The review highlights FWR’s distinctive kinematics and aerodynamic superiority compared to traditional flapping wings, fixed wings, and rotary wings, discussing recent breakthroughs in efficient, passive wing pitching and asymmetric stroke amplitude for lift enhancement. Recent experiments and remote-controlled take-off and hovering tests of single and dual-motor FWR models have showcased their effectiveness. The review compares FWR flight performance with well-developed insect-like flapping-wing micro aerial vehicles as the technology readiness level progresses from laboratory to outdoor flight testing, advancing from the initial flight of a 2.6 g prototype to the current free flight of a 60-gram model. The review also presents ongoing research in bionic flexible wing structures, flight stability and control, and transitioning between hovering and cruise flight modes for an FWR, setting the stage for potential applications.Journal of Bionic Engineerin

NG2 glia protect against prion neurotoxicity by inhibiting prostaglandin E2 signaling

Oligodendrocyte-lineage cells of patients and animal models undergo prominent changes in various neurodegenerative disorders. This raises the question of how myelinating cells interact with neurodegenerative processes. Here, we investigated the role of oligodendrocyte precursor cells (NG2 glia) in prion infections. We found that NG2 glia were activated in prion-infected cerebellar organotypic cultured slices (COCS) and in brains of prion-inoculated mice. In both model systems, depletion of NG2 glia exacerbated prion-induced neurodegeneration and accelerated prion pathology, suggesting a protective effect for NG2 glia. Loss of NG2 glia unleashed a microglial reaction promoting the biosynthesis of prostaglandin E2 (PGE2), which augmented prion toxicity in HovS cells and COCS through binding to the EP1 and EP4 receptors. Pharmacological or genetic inhibition of PGE2 biosynthesis attenuated prion-induced neurodegeneration in COCS and mice, antagonized the enhanced neurodegeneration in NG2 glia-depleted COCS and brains after prion infection, and dampened the acceleration of prion disease in NG2 glia-depleted mice. These data unveil a non-cell-autonomous interaction involving NG2 glia and microglia in prion disease and suggest that PGE2 signaling may represent an actionable target against prion diseases

NG2 glia protect against prion neurotoxicity by inhibiting microglia-to-neuron prostaglandin E2 signaling

Oligodendrocyte-lineage cells, including NG2 glia, undergo prominent changes in various neurodegenerative disorders. Here, we identify a neuroprotective role for NG2 glia against prion toxicity. NG2 glia were activated after prion infection in cerebellar organotypic cultured slices (COCS) and in brains of prion-inoculated mice. In both model systems, depletion of NG2 glia exacerbated prion-induced neurodegeneration and accelerated prion pathology. Loss of NG2 glia enhanced the biosynthesis of prostaglandin E2 (PGE2) by microglia, which augmented prion neurotoxicity through binding to the EP4 receptor. Pharmacological or genetic inhibition of PGE2 biosynthesis attenuated prion-induced neurodegeneration in COCS and mice, reduced the enhanced neurodegeneration in NG2-glia-depleted COCS after prion infection, and dampened the acceleration of prion disease in NG2-glia-depleted mice. These data unveil a non-cell-autonomous interaction between NG2 glia and microglia in prion disease and suggest that PGE2 signaling may represent an actionable target against prion diseases

Aerodynamic performance of a flyable flapping wing rotor with dragonfly-like flexible wings

Drawing inspiration from insect flapping wings, a Flapping Wing Rotor (FWR) has been developed for Micro Aerial Vehicle (MAV) applications. The FWR features unique active flapping and passive rotary kinematics of motion to achieve a high lift coefficient and flight efficiency. This study thoroughly investigates the aerodynamic performance and design of a bio-inspired flexible wing for FWR-MAVs, emphasizing its novel backward-curved wingtip and variable spanwise stiffness resembling a dragonfly's wing. The research departs from previous aerodynamic studies of FWR, which focused predominantly on rectangular and rigid wings, and delves into wing flexibility. Employing Computational Fluid Dynamics (CFD), Computational Structural Dynamics (CSD), and experimental measurements, the study demonstrates the aerodynamic benefits of the dragonfly-inspired FWR wingtip shape and its reinforced structure. Fluid-Structure Interaction (FSI) analysis is used to examine the effects of elastic deformation encompassing twist and bending on aerodynamic forces. The results underscore the importance of bending deformation in enhancing lift and power efficiency and propose a method for analysing variable stiffness along the wingspan using a vortex delay mechanism that is induced by delayed flapping motion. By comparing modelled and measured stiffness, the study validates the flexibility of the FWR wing, revealing optimal aerodynamic efficiency is achieved through moderate flexibility and spanwise stiffness variation. The curving leading-edge beam forming the sweep-back wingtip offers a practical approach to obtaining variable stiffness and aerodynamic benefits for FWR-MAVs. Using the same pair of dragonfly-like flexible wings, FWR-MAVs have effectively exhibited VTOL and hovering flight capabilities, spanning from a 25-g single-motor drive model to a 51-g dual-motor drive model. This research provides valuable insights into flexible wing design for FWR-MAVs, leveraging biomimicry to improve flight efficiency

Optimization of Minimum Negative Current BCM Synchronous Buck Converter

Non-isolated DC-DC converters are widely used in renewable energy applications, such as the hybrid energy storage system (HESS), charging and discharging system of batteries and supercapacitors and the photovoltaic power generation. With the advantages of achieving zero-voltage-switching (ZVS), high efficiency and power density, low cost, and fast dynamic response, the converters operating in boundary current mode (BCM) have caught researchers' eyes recently. Taking the synchronous buck converters as an example, this paper briefly introduces the working principle and advantages of BCM converter realize soft switching. Firstly, it is pointed out that the phenomenon of circulating energy exists in the BCM converter. Then, the relationship between circulating energy and negative current is analyzed, and an optimal control strategy of negative current minimization is proposed to reduce the circulating energy. In the condition of realizing ZVS, negative current minimization not only improves the efficiency of the converter, but also reduces the ripple of inductor current to a certain extent. Finally, the experimental platform of 100 W synchronous buck converter is built. Experimental results validate that the optimal control of minimum negative current has good effect on improving efficiency of converter and reducing the ripple of inductor current

The value of Apolipoprotein B/Apolipoprotein A1 ratio for metabolic syndrome diagnosis in a Chinese population: a cross-sectional study

BACKGROUND: The apoB/apoA1 ratio has been reported to be associated with the metabolic syndrome (MetS), and it may be a more convenient biomarker in MetS predicting. However, whether apoB/apoA1 ratio is a better indicator of metabolic syndrome than other biomarkers and what is the optimal cut-off value of apoB/apoA1 ratio as an indicator of metabolic syndrome in Chinese population remain unknown. Thus, we carried out the current study to assess the predictive value of apoB/apoA1 ratio and determine the optimal cut-off value of apoB/apoA1 ratio for diagnosing MetS in a Chinese population. METHOD: We selected 1,855 subjects with MetS and 6,265 individuals without MetS based on the inclusion and exclusion criteria from the China Health Nutrition Survey (CHNS) in 2009. MetS was identified based on the diagnostic criteria of International Diabetes Federation (2005). Logistic regression was used to estimate the association between the apoB/apoA1 ratio and risk of MetS, and receiver operating characteristics (ROC) curve analysis was performed to test the predictive value of apoB/apoA1 ratio and calculate the appropriate cut-off value. RESULTS: Compared with the lowest quartile of apoB/apoA1 ratio, subjects in the fourth quartile had a higher risk of MetS in both men [odds ratio (OR) = 2.64, 95% confidence interval (CI) =1.82-3.83] and women (OR = 5.18, 95% CI = 3.87-6.92) after adjustment for potential confounders. The optimal cut-off value of apoB/apoA1 ratio for MetS detection was 0.85 in men and 0.80 in women. Comparisons of ROC curves indicated that apoB/apoA1 ratio was better than traditional biomarkers in predicting MetS. CONCLUSION: Our results suggest that, apoB/apoA1 ratio has a promising predictive effectiveness in detection of MetS. An apoB/apoA1 ratio higher than 0.85 in men and 0.80 in women may be a promising and convenient marker of MetS