Rare coexistence of metastatic neuroblastoma of liver and solid pseudo papillary tumor of pancreas: Case report and literature review

Neuroblastoma is the second most common malignant solid tumor in children, and often metastasizes to liver, most notably in patients with stage 4S tumors. Solid pseudopapillary tumor of the pancreas (SPT) is a pancreatic borderline tumor with low malignant potential. Coexistence of these two tumors in one patient has never been reported before. Hereby, we present a case of an 8-month-old infant with coexisting tumors of SPT and metastatic neuroblastoma of liver. Dysdifferentiation of neural crest might be responsible for histogenesis of the coexisting tumors

The role of wnt signaling in diabetes-induced osteoporosis

Abstract Osteoporosis, a chronic complication of diabetes mellitus, is characterized by a reduction in bone mass, destruction of bone microarchitecture, decreased bone strength, and increased bone fragility. Because of its insidious onset, osteoporosis renders patients highly susceptible to pathological fractures, leading to increased disability and mortality rates. However, the specific pathogenesis of osteoporosis induced by chronic hyperglycemia has not yet been fully elucidated. But it is currently known that the disruption of Wnt signaling triggered by chronic hyperglycemia is involved in the pathogenesis of diabetic osteoporosis. There are two main types of Wnt signaling pathways, the canonical Wnt signaling pathway (β-catenin-dependent) and the non-canonical Wnt signaling pathway (non-β-catenin-dependent), both of which play an important role in regulating the balance between bone formation and bone resorption. Therefore, this review systematically describes the effects of abnormal Wnt pathway signaling on bone homeostasis under hyperglycemia, hoping to reveal the relationship between Wnt signaling and diabetic osteoporosis to further improve understanding of this disease

Characterization of electrical explosion of Schottky diode for one-shot switch applications

The electrical explosion characteristics of Schottky diode for one-shot switch applications were acquired by analysis of photographs of high speed camera and current-voltage histories. Four types of connections among Schottky diode, top electrode and discharge capacitor were studied. Results show that type B has the longest time (1.4 ms) of optical radiation and highest energy consumption, which makes it easier to turn on the switch. The charge flux of plasma was determined to be 24.5 Q/(s m2) by parallel electrode plates method. Atomic emission spectroscopic measurements were devoted to determine plasma temperature and density during electrical explosion. Results show that temperature is between 4000 K and 5000 K, and density is about 1024 m−3. The one-shot switch based on ceramics has been fabricated and characterized and the results show that the peak current and the rise time are about 963.77 A and 381.6 ns, respectively

Preparation of MIP Microspheres by Precipitation Polymerization with 1-Phenyl-1-propanol as Template

Molecular imprinting polymer microspheres were prepared by precipitation polymerization with methacrylic acid as functional monomer and 1-phenyl-1-propanol as template. The effects of synthesis conditions, including the kind of solvent, polymerization temperature, the concentration of template and initiator, rotational speed and pre-polymerization time, on the characteristics of the molecularly imprinted polymer microspheres were studied. The rebinding experiments showed that the molecularly imprinted polymer microspheres synthesized by precipitation polymerization at 60 degrees C, with acetonitrile as solvent and the concentrations of both template and initiator of 0.01mol L-1, have good specific recognition and higher affinity capacity

Preparation of MIP Microspheres by Precipitation Polymerization with 1-Phenyl-1-propanol as Template

Molecular imprinting polymer microspheres were prepared by precipitation polymerization with methacrylic acid as functional monomer and 1-phenyl-1-propanol as template. The effects of synthesis conditions, including the kind of solvent, polymerization temperature, the concentration of template and initiator, rotational speed and pre-polymerization time, on the characteristics of the molecularly imprinted polymer microspheres were studied. The rebinding experiments showed that the molecularly imprinted polymer microspheres synthesized by precipitation polymerization at 60 degrees C, with acetonitrile as solvent and the concentrations of both template and initiator of 0.01mol L-1, have good specific recognition and higher affinity capacity

Assessment of Amino Acid Neurotransmitters in Rat Brain Microdialysis Samples by High-Performance Liquid Chromatography with Coulometric Detection

<div><p>A simple method was developed for simultaneous determination of five amino acid neurotransmitters (taurine, glutamate, aspartate, glycine, and γ-aminobutyric acid) in brain microdialysates by high-performance liquid chromatography with coulometric detection. The microdialysates were derivatized with <i>o</i>-phthalaldehyde in 5 mM sodium sulfite and separated within 17 min using isocratic elution. Detection parameters for these transmitters were linearity (<i>r</i>²) > 0.999 over the concentration range from 0.1 to 15.00 µM (0.01–1.00 µM for GABA); reproducibility 2.88%–11.67% (relative standard deviation); the limits of detection 4.4–17.2 fmol; and recovery 86.66%–103.42%. This method was successfully applied to analyze these neurotransmitters in the brain. The changes of neurotransmitters were also investigated via local administration of potassium chloride and bicuculline, which was a γ-aminobutyric acid receptor antagonist. It was found that the developed method is more efficient as compared to previously reported methods in simultaneously determining five major neurotransmitters because it shows quick separation and sensitive detection, and is easy to operate. This method can be a practical choice for continuous monitoring of the amino acid neurotransmitters<i>in vivo</i>.</p></div