DC-Informative Joint Color-Frequency Modulation for Visible Light Communications

In this paper, we consider the problem of constellation design for a visible light communication (VLC) system using red/green/blue light-emitting diodes (RGB LED), and propose a method termed DC-informative joint color-frequency modulation (DCI-JCFM). This method jointly utilizes available diversity resources including different optical wavelengths, multiple baseband subcarriers, and adaptive DC-bias. Constellation is designed in a high dimensional space, where the compact sphere packing advantage over lower dimensional counterparts is utilized. Taking into account multiple practical illumination constraints, a non-convex optimization problem is formulated, seeking the least error rate with a fixed spectral efficiency. The proposed scheme is compared with a decoupled scheme, where constellation is designed separately for each LED. Notable gains for DCI-JCFM are observed through simulations where balanced, unbalanced and very unbalanced color illuminations are considered.Comment: submitted to Journal of Lightwave Technology, Aug. 5th 201

Hybrid Millimeter-Wave Systems: A Novel Paradigm for HetNets

Heterogeneous Networks (HetNets) are known to enhance the bandwidth efficiency and throughput of wireless networks by more effectively utilizing the network resources. However, the higher density of users and access points in HetNets introduces significant inter-user interference that needs to be mitigated through complex and sophisticated interference cancellation schemes. Moreover, due to significant channel attenuation and presence of hardware impairments, e.g., phase noise and amplifier nonlinearities, the vast bandwidth in the millimeter-wave band has not been fully utilized to date. In order to enable the development of multi-Gigabit per second wireless networks, we introduce a novel millimeter-wave HetNet paradigm, termed hybrid HetNet, which exploits the vast bandwidth and propagation characteristics in the 60 GHz and 70-80 GHz bands to reduce the impact of interference in HetNets. Simulation results are presented to illustrate the performance advantage of hybrid HetNets with respect to traditional networks. Next, two specific transceiver structures that enable hand-offs from the 60 GHz band, i.e., the V-band to the 70-80 GHz band, i.e., the E-band, and vice versa are proposed. Finally, the practical and regulatory challenges for establishing a hybrid HetNet are outlined.Comment: 12 pages, 5 Figures, IEEE Communication Magazine. In pres

Accurate Reconstruction of Molecular Phylogenies for Proteins Using Codon and Amino Acid Unified Sequence Alignments (CAUSA)

Based on molecular clock hypothesis, and neutral theory of molecular evolution, molecular phylogenies have been widely used for inferring evolutionary history of organisms and individual genes. Traditionally, alignments and phylogeny trees of proteins and their coding DNA sequences are constructed separately, thus often different conclusions were drawn. Here we present a new strategy for sequence alignment and phylogenetic tree reconstruction, codon and amino acid unified sequence alignment (CAUSA), which aligns DNA and protein sequences and draw phylogenetic trees in a unified manner. We demonstrated that CAUSA improves both the accuracy of multiple sequence alignments and phylogenetic trees by solving a variety of molecular evolutionary problems in virus, bacteria and mammals. Our results support the hypothesis that the molecular clock for proteins has two pointers existing separately in DNA and protein sequences. It is more accurate to read the molecular clock by combination (additive) of these two pointers, since the ticking rates of them are sometimes consistent, sometimes different. CAUSA software were released as Open Source under GNU/GPL license, and are downloadable free of charge from the website www.dnapluspro.com

Berberine hydrochloride: anticancer activity and nanoparticulate delivery system

Wen Tan, Yingbo Li, Meiwan Chen, Yitao WangState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao Special Administrative Region, ChinaBackground: Berberine hydrochloride is a conventional component in Chinese medicine, and is characterized by a diversity of pharmacological effects. However, due to its hydrophobic properties, along with poor stability and bioavailability, the application of berberine hydrochloride was hampered for a long time. In recent years, the pharmaceutical preparation of berberine hydrochloride has improved to achieve good prospects for clinical application, especially for novel nanoparticulate delivery systems. Moreover, anticancer activity and novel mechanisms have been explored, the chance of regulating glucose and lipid metabolism in cancer cells showing more potential than ever. Therefore, it is expected that appropriate pharmaceutical procedures could be applied to the enormous potential for anticancer efficacy, to give some new insights into anticancer drug preparation in Chinese medicine.Methods and results: We accessed conventional databases, such as PubMed, Scope, and Web of Science, using “berberine hydrochloride”, “anti-cancer mechanism”, and “nanoparticulate delivery system” as search words, then summarized the progress in research, illustrating the need to explore reprogramming of cancer cell metabolism using nanoparticulate drug delivery systems.Conclusion: With increasing research on regulation of cancer cell metabolism by berberine hydrochloride and troubleshooting of issues concerning nanoparticulate delivery preparation, berberine hydrochloride is likely to become a natural component of the nanoparticulate delivery systems used for cancer therapy. Meanwhile, the known mechanisms of berberine hydrochloride, such as decreased multidrug resistance and enhanced sensitivity of chemotherapeutic drugs, along with improvement in patient quality of life, could also provide new insights into cancer cell metabolism and nanoparticulate delivery preparation.Keywords: berberine hydrochloride, anticancer mechanisms, nanoparticulate drug progres

Preparation and adsorbing sodium borohydride of porous hollow capsules

AbstractSodium borohydride, a solid material, has great attractive for its hydrogen storage and preparation properties. The solubility of sodium borohydride in water is up to 35% at room temperature. It can react with water for generating hydrogen. The merits of this reaction include high purity, mild reaction conditions and the high theoretical density of hydrogen generation. Complete hydrolysis of sodium borohydride can produce hydrogen and sodium metaborate, which can be recovered by advanced technology for sodium borohydride recycling. Porous hollow capsules containing nickel boride were prepared and used as storage and reaction space for sodium borohydride. The influences of the concentration of polymer solution, the ratio of the coagulation bath, the concentration and temperature on the porous structure of hollow capsule were investigated. The adsorption of porous hollow capsule was influenced and optimized by soaking time, adsorption conditions, the drying temperature and time. The best conditions of preparation of porous hollow capsule are: 15 wt% PVDF into capsule system configuration, with adding 15wt % attapulgite or 5 wt% PVP. The adsorption amount is up to 36%. The preparation method of porous hollow capsule is simple and easy to operate, low energy consumption, simple process only including dissolving, mixing, molding, adsorption and drying. The structure of porous hollow is stable and easy to storage and use. Hydrogen can be simple to release when mixed the adsorbed capsules with water