Emergence of multicluster chimera states

We thank Prof. L. Huang for helpful discussions. This work was partially supported by ARO under Grant No. W911NF-14-1-0504 and by NSF of China under Grant No. 11275003. The visit of NY to Arizona State University was partially sponsored by Prof. Z. Zheng and the State Scholarship Fund of China.Peer reviewedPublisher PD

Expression profiling of ascorbic acid–related transporters in human and mouse eyes

PURPOSE: Ascorbic acid (AsA) is an important antioxidant in the eye. Ascorbic acid is usually transported by sodium-dependent AsA transporters (SVCTs), and dehydroascorbic acid (DHA) by glucose transporters (GLUTs). This study investigates these AsA-related transporters in human compared with mouse eyes. METHODS: Five pairs of human donor eyes and 15 pairs of mouse eyes were collected. Immunofluorescence and in situ hybridization were performed to detect SVCTs and GLUTs expression in the ciliary epithelium, retina, and lens epithelial cells (LECs). These tissues were isolated with laser microdissection followed by extraction of total RNA. Quantitative PCR (qPCR) was performed to examine the mRNA level of SVCTs and GLUTs in human and mouse ocular tissues. RESULTS: Immunofluorescence and in situ hybridization showed SVCT2 and GLUT1 expression in human ciliary epithelium with varied distributions. Sodium-dependent AsA transporter 2 is expressed only in the pigmented epithelium (PE), and GLUT1 is predominately expressed in the nonpigmented epithelium (NPE). However, SVCT2 was not identified in mouse ciliary epithelium, whereas GLUT1 expressed in both PE and NPE. Laser microdissection and qPCR revealed high levels of SVCT2 mRNA in human RPE cells and murine neural retina. Sodium-dependent AsA transporter 1 mRNA could be detected only in human and murine LECs. Glucose transporter 3 and GLUT4 mRNA could not be detected in either the human or mouse ciliary processes or in the lens epithelium. CONCLUSIONS: These fundamental findings indicate AsA transporter expression in eyes of humans is significantly different compared with mice. This may explain why human aqueous and vitreous humors contain higher AsA levels compared with other animals

Mesoscopic Interactions and Species Coexistence in Evolutionary Game Dynamics of Cyclic Competitions

Date of Acceptance: 27/11/2014Peer reviewedPublisher PD

[1,2-Bis(pyridin-2-ylmeth­oxy)benzene-κ4 N,O,O′,N′]bis­(nitrato-κO)cobalt(II)

In the title compound, [Co(NO3)2(C18H16N2O2)], the CoII ion is six-coordinated in a distorted octa­hedral environment defined by two O and two N atoms from the ligand and by two O atoms from two nitrate anions. A two-dimensional network parallel to the ab plane is built up by C—H⋯O hydrogen bonds, which link adjacent mol­ecules in the crystal structure

Effect of home nutrition support and nursing intervention on patients with enteral nutrition

目的  探讨居家营养支持护理干预对预防家庭肠内营养支持患者并发症发生和提高护理工作满意度的效果。方法  以在我院实行家庭肠内营养支持治疗与规范化护理模式的213例患者作为观察组；在南京市某三甲医院进行家庭肠内营养支持治疗及传统护理模式的185例患者作为对照组，比较两组患者6个月后的并发症发生率及对护理工作的满意度。结果  观察组患者在导管堵塞和腹泻发生率方面明显低于对照组（P＜0.01），对护理工作满意度明显高于对照组，且差异有统计学意义（97% vs.74%，P＜0.01）。结论  规范化的护理干预可有效降低家庭肠内营养支持患者并发症的发生率，改善患者预后，并提高患者对护理工作的满意度。Objective：To investigate the effect of home nutrition support nursing intervention on prevention of complications and improve the satisfaction degree of nursing in patients with enteral nutrition support. Methods: 213 cases in our hospital implementation of home enteral nutrition support nursing treatment and standardized patients as the observation group; 185 cases of home enteral nutrition support therapy and the traditional nursing mode of patients from Nanjing hospital as control group. The incidence of complications and nursing satisfaction were compared between the two groups after 6 months. Results: The incidence of catheter blockage and diarrhea in the observation group was significantly lower than the control group (P <0.01), the degree of satisfaction was significantly higher than the control group, and the difference was statistically significant (97% vs.74%, P<0.01). Conclusion: Standardized nursing intervention can effectively reduce the incidence of complications in patients with enteral nutrition support, improve the prognosis of patients, and improve the patient’s satisfaction with nursing work

[1,2-Bis(pyridin-2-ylmeth­oxy)benzene-κ4 N,O,O′,N′]dichloridocopper(II)

In the title compound, [CuCl2(C18H16N2O2)], the CuII atom lies on a twofold axis and is six-coordinated in a distorted octa­hedral environment defined by two N and two O atoms from the ligand and by two Cl atoms. In the crystal, π–π inter­actions [centroid–centroid distance = 3.838 (1) Å] and C—H⋯Cl hydrogen bonds link adjacent mol­ecules into a chain structure along [101]

Self-adaptation of chimera states

This work was partially supported by the National Natural Science Foundation of China (Grants No. 11647052 and No. 61431012), by the Scientific Research Program Funded by Shaanxi Provincial Education Department (Program No. 17JK0553), by the Young Talent fund of University Association for Science and Technology in Shaanxi, China (Program No. 20170606), and by the Natural Science Basic Research Plan in Shaanxi Province of China (Program No. 2018JQ1010). Z.-G.H acknowledges support of K. C. Wong Education Foundation. Y.-C.L is supported by ONR under Grant No. N00014-16-1-2828.Peer reviewedPublisher PD

Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate.

Type IIA topoisomerases (Top2s) manipulate the handedness of DNA crossovers by introducing a transient and protein-linked double-strand break in one DNA duplex, termed the DNA-gate, whose opening allows another DNA segment to be transported through to change the DNA topology. Despite the central importance of this gate-opening event to Top2 function, the DNA-gate in all reported structures of Top2-DNA complexes is in the closed state. Here we present the crystal structure of a human Top2 DNA-gate in an open conformation, which not only reveals structural characteristics of its DNA-conducting path, but also uncovers unexpected yet functionally significant conformational changes associated with gate-opening. This structure further implicates Top2's preference for a left-handed DNA braid and allows the construction of a model representing the initial entry of another DNA duplex into the DNA-gate. Steered molecular dynamics calculations suggests the Top2-catalyzed DNA passage may be achieved by a rocker-switch-type movement of the DNA-gate