Effector Caspases and Leukemia

Caspases, a family of aspartate-specific cysteine proteases, play a major role in apoptosis and a variety of physiological and pathological processes. Fourteen mammalian caspases have been identified and can be divided into two groups: inflammatory caspases and apoptotic caspases. Based on the structure and function, the apoptotic caspases are further grouped into initiator/apical caspases (caspase-2, -8, -9, and -10) and effector/executioner caspases (caspase-3, -6, and -7). In this paper, we discuss what we have learned about the role of individual effector caspase in mediating both apoptotic and nonapoptotic events, with special emphasis on leukemia-specific oncoproteins in relation to effector caspases

From the Complete Yang Model to Snyder's Model, de Sitter Special Relativity and Their Duality

By means of Dirac procedure, we re-examine Yang's quantized space-time model, its relation to Snyder's model, the de Sitter special relativity and their UV-IR duality. Starting from a dimensionless dS_5-space in a 5+1-d Mink-space a complete Yang model at both classical and quantum level can be presented and there really exist Snyder's model, the dS special relativity and the duality.Comment: 7 papge

Upregulation of Endogenous HMOX1 Expression by a Computer-Designed Artificial Transcription Factor

Heme oxygenase-1 (HO-1) is well known as a cytoprotective factor. Research has revealed that it is a promising therapeutic target for cardiovascular diseases. In the current study, an HMOX1 (HO-1 gene) enhancer-specific artificial zinc-finger protein (AZP) was designed using bioinformatical methods. Then, an artificial transcription factor (ATF) was constructed based on the AZP. In the ATF, the p65 functional domain was used as the effector domain (ED), and a nuclear localization sequence (NLS) was also included. We next analyzed the affinity of the ATF to the HMOX1 enhancer and the effect of the ATF on endogenous HMOX1 expression. The results suggest that the ATF could effectively upregulate endogenous HMOX1 expression in ECV304 cells. With further research, the ATF could be developed as a potential drug for cardiovascular diseases

Cooperative three- and four- player quantum games

A cooperative multi-player quantum game played by 3 and 4 players has been studied. Quantum superposed operator is introduced in this work which solves the non-zero sum difficulty in previous treatment. The role of quantum entanglement of the initial state is discussed in details.Comment: 7 pages with 3 figures. To appear in Physics Letters

A Weak Monotonicity Based Muscle Fatigue Detection Algorithm for a Short-Duration Poor Posture Using sEMG Measurements

Muscle fatigue is usually defined as a decrease in the ability to produce force. The surface electromyography (sEMG) signals have been widely used to provide information about muscle activities including detecting muscle fatigue by various data-driven techniques such as machine learning and statistical approaches. However, it is well-known that sEMG signals are weak signals (low amplitude of the signals) with a low signal-to-noise ratio, data-driven techniques cannot work well when the quality of the data is poor. In particular, the existing methods are unable to detect muscle fatigue coming from static poses. This work exploits the concept of weak monotonicity, which has been observed in the process of fatigue, to robustly detect muscle fatigue in the presence of measurement noises and human variations. Such a population trend methodology has shown its potential in muscle fatigue detection as demonstrated by the experiment of a static pose.Comment: 4 pages, 4 figures. This work has been submitted to the IEEE EMBC for possible publicatio

A new approach to the chronology of caves 268/272/275 in the Dunhuang Mogao Grottoes: combining radiocarbon dates and archaeological information within a Bayesian statistical framework

The construction chronology of three of the earliest Dunhuang Mogao Grottoes (Caves 268, 272, and 275) has been the subject of ongoing debate for over half a century. This chronology is a crucial topic in terms of further understanding of the establishment of the Dunhuang Mogao Grottoes, early Buddhism in the Gansu corridor, and its relationship with Buddhism developed in the Central Plains. Building upon archaeological, art historical and radiocarbon (14C) dating studies, we integrate new 14C data with these previously published findings utilizing Bayesian statistical modeling to improve the chronological resolution of this issue. Thus, we determine that all three of these caves were constructed around AD 410–440, suggesting coeval rather than sequential construction