18 research outputs found

    Composite anodes for lithium-ion batteries: status and trends

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    Recent trends in the graphene-based sensors for the detection of hydrogen peroxide

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    The gene and microRNA networks of stem cells and reprogramming

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    High-mobility group box 1 is a promising diagnostic and therapeutic monitoring biomarker in Cancers: A review

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    Smart systems related to polypeptide sequences

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    RNA Therapeutics: How Far Have We Gone?

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    In recent years, the RNA molecule became one of the most promising targets for therapeutic intervention. Currently, a large number of RNA-based therapeutics are being investigated both at the basic research level and in late-stage clinical trials. Some of them are even already approved for treatment. RNA-based approaches can act at pre-mRNA level (by splicing modulation/correction using antisense oligonucleotides or U1snRNA vectors), at mRNA level (inhibiting gene expression by siRNAs and antisense oligonucleotides) or at DNA level (by editing mutated sequences through the use of CRISPR/Cas). Other RNA approaches include the delivery of in vitro transcribed (IVT) mRNA or the use of oligonucleotides aptamers. Here we review these approaches and their translation into clinics trying to give a brief overview also on the difficulties to its application as well as the research that is being done to overcome them.info:eu-repo/semantics/publishedVersio

    Information technology adoption: a review of the literature and classification

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    Exogenous enzymes upgrade transgenesis and genetic engineering of farm animals

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