The impact of compassion from others and self-compassion on psychological distress, flourishing, and meaning in life among university students

Objectives: Research shows that compassion from others and from the self may enable university students to face, overcome, and bounce back from adversity and generate a greater sense of thriving and meaning in life. However, the underlying processes are largely unknown. The present study aimed to examine the associations of compassion with psychological distress, flourishing, and meaning in life among university students and explore the mechanisms underlying these associations. Methods: A total of 536 Hong Kong university students completed questionnaires measuring their experiences of compassion from others, self-compassion, resilience, psychological distress, flourishing, and meaning in life. Results: Serial mediation analyses showed that compassion from others was associated positively with self-compassion, which was, in turn, linked to greater resilience and consequently lower levels of psychological distress and higher levels of flourishing and meaning in life. Conclusions: Our findings reveal the associations of compassion from others and self-compassion with the well-being and life meaning of university students. The findings highlight the importance of being open and receptive to love and kindness from others. The findings also point to the importance of developing a caring attitude toward oneself

MECHANICAL PROPERTIES OF INCONEL 617B ALLOYAT ULTRA-SUPERCRITICAL TEMPERATURE

A group of tests on uniaxial tension and low cyclic fatigue under constant strain amplitude at room temperature and 700 ℃ have been carried out for ultra-supercritical Inconel 617B alloy. Based on new method of finite-element-analysis aided testing on funnel specimen,we can get uniaxial tensile true stress-true strain curves until fracture. Then,fractured stress and strain,described equation of the true stress-true strain curves and parameters of the equation at two temperatures are obtained. At last,Evolutive behavior of cyclic stress,cyclic constitutive relationships,relationships between strain amplitudes and cyclic lives,ultra-supercritical temperature effects are studied. The results show that,ultra-supercritical temperature makes the elastic modulus of Inconel 617B,yield strength,ultimate strength,critical breaking stress,breaking strain and stress triaxiality of centre point on funnel root transversal surface after specimen necking decrease significantly. The curves obtained by FAT are well described by the new equation of the true stress-strain relationship. The finite-element-analysis shows that stress triaxiality of centre on funnel root transversal surface is the largest than other points,the maximum of fractured stress triaxiality at 700 ℃ is much lower than room temperature. 617B Inconel alloy performs obvious cyclic hardening characteristics at two temperatures. The cyclic stable life percent of 617B Inconel alloy reduces greatly and the anti-fatigue property weakens significantly under ultrasupercritical temperature. Manson-Coffin life-prediction model can describe the low cyclic fatigue life under two temperatures very well

Mechanically adaptive nanocomposites with cellulose nanocrystals: Strain-field mapping with digital image correlation

Strain-transfer plays a key role in overall modulus of mechanically adaptive nanomaterials. Herein, mechanically adaptive nanocomposites were prepared via introducing cellulose nanocrystal (CNC) percolating network into poly butyl methacrylate (PBMA) with polyethylene glycol (PEG) as a stabilizer. The prepared PBMA/CNC nanocomposites were soaked in deionized water at 23 °C and 37 °C for one week to investigate their mechanically adaption. The interactions between PEG, CNC, and PBMA were assessed by Fourier Transform infrared, X-ray diffraction, and X-ray photoelectron spectroscopy. Incorporation of PEG to CNC and PBMA/CNC nanocomposites on the morphological and thermal properties was also investigated. The mechanical adaption of PBMA/CNC nanocomposites after switching dry-to-wet state and surrounding temperature (soaked in deionized water at 23 °C and 37 °C for one week, respectively) was evaluated by mechanical testing. Meantime, digital image correlation (DIC) was firstly used to study strain transfer mechanism in mechanical adaption which was carried out in real-time synchronized with mechanical measurement. It indicated that PEG improved the dispersion of CNC in PBMA/CNC nanocomposite and its thermal properties. Furthermore, CNC with PEG modification bridged PBMA during crack propagation and promoted the stress and stain transfer in PBMA/CNC nanocomposites according to DIC analysis

The Frequency and clinical significance of IDH1 mutations in Chinese acute myeloid leukemia patients.

OBJECTIVE: Mutations in the gene encoding isocitrate dehydrogenease 1 (IDH1) occur in various hematopoietic tumors including acute myeloid leukemia (AML), myeloproliferative neoplasms and myelodysplastic syndromes. IDH1 mutations are significant in both diagnosis and prognosis of these conditions. In the present study we determined the prevalence and clinical significance of IDH1 mutations in 349 samples from newly diagnosed AML patients. RESULTS: Of the 349 AML patient specimens analyzed, 35 (10.03%) were found to have IDH1 mutations including 4 IDH1 R132 mutations and 31 non-R132 mutations. IDH1 non-R132 mutations were largely concentrated within AML-M1 (35.72%, p<0.01). We identified five IDH1 mutations that were novel to AML: (1) c.299 G>A, p.R100Q; (2) c.311G>T, p.G104V; (3) c.322T>C, p.F108L; (4) c.356G>A, p.R119Q; and (5) c.388A>G, p.I130V. In addition, we identified three IDH1 mutations that were previously described in AML. The frequency of IDH1 mutations in AML patients with normal karyotype was 9.9%. IDH1 non-R132 mutations were concurrent with mutations in FLT3-ITD (p<0.01), CEBPA (p<0.01), and NRAS (p<0.01), as well as the overexpression of MN1 (p<0.01) and WT1(p<0.01). The overall survival (OS) in the patients with IDH1 non-R132 mutations compared to patients without IDH1 mutations don't reach statistically significance (median 521 days vs median: not reached; n.s.). CONCLUSION: IDH1 non-R132 mutations occurred frequently in newly diagnosed adult Chinese AML patients, and these mutations were associated with genetic alterations. The OS was not influenced by IDH1 non-R132 mutations in the present study

Summary of clinical characteristics in IDH1 mutation patient.

<p>Summary of clinical characteristics in IDH1 mutation patient.</p

Patient demographics, clinical data and cytogenetic changes in AML patients with/without <i>IDH1</i> mutations.

<p>Patient demographics, clinical data and cytogenetic changes in AML patients with/without <i>IDH1</i> mutations.</p

Genetic alterations in AML patients with/without <i>IDH1</i> mutations.

<p>Genetic alterations in AML patients with/without <i>IDH1</i> mutations.</p

Survival curve of AML patients.

<p>Kaplan-Meier curve shows OS (A) in patients with IDH1non-R132 mutations and IDH1 wild type. The OS (B) in patients with non-R132 IDH1 mutations who were transplanted or non-transplanted.</p

DNA sequencing of <i>IDH1</i> mutations.

<p>DNA sequencing chromatograms of representative heterozygous <i>IDH1</i> mutations and reference wild type <i>IDH1</i>.</p

Incidence of different subtypes of <i>IDH1</i> mutations.

<p>Eight <i>IDH1</i> mutations were detected in 35/349 patients.</p