1,441 research outputs found
The power and statistical behaviour of allele-sharing statistics when applied to models with two disease loci
We have evaluated the power for detecting a common trait determined by two loci, using seven statistics, of which five are implemented in the computer program SimWalk2, and two are implemented in GENEHUNTER. Unlike most previous reports which involve evaluations of the power of allele-sharing statistics for a single disease locus, we have used a simulated data set of general pedigrees in which a two-locus disease is segregating and evaluated several nonparametric linkage statistics implemented in the two programs. We found that the power for detecting linkage using the S(all) statistic in GENEHUNTER (GH, version 2.1), implemented as statistic E in SimWalk2 (version 2.82), is different in the two. The P values associated with statistic E output by SimWalk2 are consistently more conservative than those from GENEHUNTER except when the underlying model includes heterogeneity at a level of 50% where the P values output are very comparable. On the other hand, when the thresholds are determined empirically under the null hypothesis, S(all) in GENEHUNTER and statistic E have similar powe
The theory analysis and design for large parameter weak signal detector based on bistable stochastic resonance
Volume 3 Issue 11 (November 2015
Direct tunneling through high- amorphous HfO: effects of chemical modification
We report first principles modeling of quantum tunneling through amorphous
HfO dielectric layer of metal-oxide-semiconductor (MOS) nanostructures in
the form of n-Si/HfO/Al. In particular we predict that chemically modifying
the amorphous HfO barrier by doping N and Al atoms in the middle region -
far from the two interfaces of the MOS structure, can reduce the
gate-to-channel tunnel leakage by more than one order of magnitude. Several
other types of modification are found to enhance tunneling or induce
substantial band bending in the Si, both are not desired from leakage point of
view. By analyzing transmission coefficients and projected density of states,
the microscopic physics of electron traversing the tunnel barrier with or
without impurity atoms in the high- dielectric is revealed.Comment: 5 pages, 5 figure
Anisotropic screen space rendering for particle-based fluid simulation
This paper proposes a real-time fluid rendering method based on the screen space rendering scheme for particle-based fluid simulation. Our method applies anisotropic transformations to the point sprites to stretch the point sprites along appropriate axes, obtaining smooth fluid surfaces based on the weighted principal components analysis of the particle distribution. Then we combine the processed anisotropic point sprite information with popular screen space filters like curvature flow and narrow-range filters to process the depth information. Experiments show that the proposed method can efficiently resolve the issues of jagged edges and unevenness on the surface that existed in previous methods while preserving sharp high-frequency details
Two-color atom guide and 1D optical lattice using evanescent fields of high-order transverse modes
We propose a two-color scheme of atom guide and 1D optical lattice using
evanescent light fields of different transverse modes. The optical waveguide
carries a red-detuned light and a blue-detuned light, with both modes far from
resonance. The atom guide and 1D optical lattice potentials can be transformed
to each other by using a Mach-Zehnder interferometer to accurately control mode
transformation. This might provide a new approach to realize flexible
transition between the guiding and trapping states of atoms.Comment: 18 pages, 12 figures, 1 tabl
Minimum Joint Depth for Moment Frames with High-Strength Materials
This paper reports results from four large-scale interior beam column connections without transverse beams or slabs tested under reversed cyclic displacements. The specimens, which included the first of interior beam-column connections constructed with Grade 100 (690) reinforcement with bar deformations similar to those available in U.S. practice, had Grade 60 or 100 (420 or 690) bars, 4 or 10 ksi (28 or 69 MPa) concrete, and varied column depthto-beam bar diameter ratios. The specimens all exhibited strengths greater than the nominal strength, retained at least 80% of their strength to drift ratios exceeding 5%, and exceeded ACI 374 acceptance criteria at a 3% drift ratio for components of special moment frames, demonstrating that well-detailed joints constructed with high-strength materials behave satisfactorily. The data add evidence that joints constructed with high-strength concrete exhibit less bond decay, and recommendations are made for accounting for this effect in design. Results from the specimen constructed with normal-strength materials, considered in the context of prior tests, suggest a need to increase the minimum joint depth for special moment frames. Considerable improvement in behavior associated with reduced bond damage within the joint is obtained from a 20% increase in the minimum column depth-to-beam bar diameter ratio required in ACI 318-19
Spin-dependent thermoelectric transport through double quantum dots
We study thermoelectric transport through double quantum dots system with
spin-dependent interdot coupling and ferromagnetic electrodes by means of the
non-equilibrium Green function in the linear response regime. It is found that
the thermoelectric coefficients are strongly dependent on the splitting of
interdot coupling, the relative magnetic configurations and the spin
polarization of leads. In particular, the thermoelectric efficiency can achieve
considerable value in parallel configuration when the effective interdot
coupling and tunnel coupling between QDs and the leads for spin-down electrons
are small. Moreover, the thermoelectric efficiency increases with the intradot
Coulomb interactions increasing and can reach very high value at an appropriate
temperature. In the presence of the magnetic field, the spin accumulation in
leads strongly suppresses the thermoelectric efficiency and a pure spin
thermopower can be obtained.Comment: 5 figure
Clinical course and outcome of 107 patients infected with the novel coronavirus, SARS-CoV-2, discharged from two hospitals in Wuhan, China.
BACKGROUND: In December 2019, coronavirus disease 2019 (COVID-19) outbreak was reported from Wuhan, China. Information on the clinical course and prognosis of COVID-19 was not thoroughly described. We described the clinical courses and prognosis in COVID-19 patients. METHODS: Retrospective case series of COVID-19 patients from Zhongnan Hospital of Wuhan University in Wuhan and Xishui Hospital, Hubei Province, China, up to February 10, 2020. Epidemiological, demographic, and clinical data were collected. The clinical course of survivors and non-survivors were compared. Risk factors for death were analyzed. RESULTS: A total of 107 discharged patients with COVID-19 were enrolled. The clinical course of COVID-19 presented as a tri-phasic pattern. Week 1 after illness onset was characterized by fever, cough, dyspnea, lymphopenia, and radiological multi-lobar pulmonary infiltrates. In severe cases, thrombocytopenia, acute kidney injury, acute myocardial injury, and adult respiratory distress syndrome were observed. During week 2, in mild cases, fever, cough, and systemic symptoms began to resolve and platelet count rose to normal range, but lymphopenia persisted. In severe cases, leukocytosis, neutrophilia, and deteriorating multi-organ dysfunction were dominant. By week 3, mild cases had clinically resolved except for lymphopenia. However, severe cases showed persistent lymphopenia, severe acute respiratory dyspnea syndrome, refractory shock, anuric acute kidney injury, coagulopathy, thrombocytopenia, and death. Older age and male sex were independent risk factors for poor outcome of the illness. CONCLUSIONS: A period of 7-13 days after illness onset is the critical stage in the COVID-19 course. Age and male gender were independent risk factors for death of COVID-19
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