Effects of ascorbic acid supplementation on oxidative stress markers in healthy women following a single bout of exercise

Abstract Background Ascorbic acid is a water-soluble chain breaking antioxidant. It scavenges free radicals and reactive oxygen species (ROS), which are produced during metabolic pathways. Exercise can produce an imbalance between ROS and antioxidants, leading to oxidative stress-related tissue damages. This study was designed to determine the effects of ascorbic acid supplementation on circulating biomarkers of oxidative stress and muscle damage following a single bout of exercise. Methods In a crossover design with a 1 wk. wash-out period, 19 healthy women performed 30 min moderate-intensity cycling after ingesting 1000 mg of ascorbic acid (AA) or placebo. Blood samples were taken immediately before, immediately after and 30 min post-exercise to determine plasma albumin, total protein, glucose, oxidative stress and muscle damage markers. Results Plasma albumin and total protein levels increased immediately after exercise in placebo alongside slight reductions in glucose (p = 0.001). These effects were absent in AA cohort. Ferric reducing ability of plasma and vitamin C levels in AA cohort significantly increased after exercise (p < 0.05). Superoxide dismutase activity was significantly elevated after exercise (p = 0.002) in placebo but not AA. Plasma malondialdehyde did not change after exercise in placebo but was significantly decreased in AA (p < 0.05). The exercise protocol promoted slight muscle damage, reflected in significant increases in total creatine kinase in all subjects after exercise. On the other hand, plasma C-reactive protein and lactate dehydrogenase remained unchanged. Conclusion Supplementation with ascorbic acid prior exercise improves antioxidant power but does not prevent muscle damage

Endoscopic Sleeve Gastroplasty in the Armamentarium of Bariatric Treatment in Thailand: A TAGE-TSMBS Joint Addendum Statement to TSMBS Consensus Guideline

The Thai bariatric surgery Society of Metabolic and Bariatric Surgery (TSMBS) has recently published a consensus guideline for the treatment of obesity, which has become an emerging health crisis in Thailand. As endoscopic sleeve gastroplasty (ESG) lately became available in the country, the TSMBS and the Thai Association for Gastrointestinal Endoscopy (TAGE) then agreed to propose this addendum statement that aims to standardize the patient selection protocol, physician credentialing, and procedural data monitoring in order to safely and effectively incorporate ESG into the armamentarium of bariatric treatment of Thailand