1 research outputs found
Surface-Tethered Iterative Carbohydrate Synthesis: A Spacer Study
Comparative
study of Surface-Tethered Iterative Carbohydrate Synthesis
(STICS) using HPLC-assisted experimental setup clearly demonstrates
benefits of using longer spacer-anchoring systems. The use of mixed
self-assembled monolayers helps provide the required space for glycosylation
reaction around the immobilized glycosyl acceptor. Both extension
of the spacer length and using mixed self-assembled monolayers help
promote the reaction, and the beneficial effects may include moving
the glycosyl acceptor further out into solution and providing additional
conformational flexibility. It is possible that surface-immobilized
glycosyl acceptors with a longer spacer (C8–O–C8)-lipoic
acid have a higher tendency to mimic a solution-phase reaction environment
than acceptors with shorter spacers