AON: Towards Arbitrarily-Oriented Text Recognition

Recognizing text from natural images is a hot research topic in computer vision due to its various applications. Despite the enduring research of several decades on optical character recognition (OCR), recognizing texts from natural images is still a challenging task. This is because scene texts are often in irregular (e.g. curved, arbitrarily-oriented or seriously distorted) arrangements, which have not yet been well addressed in the literature. Existing methods on text recognition mainly work with regular (horizontal and frontal) texts and cannot be trivially generalized to handle irregular texts. In this paper, we develop the arbitrary orientation network (AON) to directly capture the deep features of irregular texts, which are combined into an attention-based decoder to generate character sequence. The whole network can be trained end-to-end by using only images and word-level annotations. Extensive experiments on various benchmarks, including the CUTE80, SVT-Perspective, IIIT5k, SVT and ICDAR datasets, show that the proposed AON-based method achieves the-state-of-the-art performance in irregular datasets, and is comparable to major existing methods in regular datasets.Comment: Accepted by CVPR201

Trimebutine Promotes Glioma Cell Apoptosis as a Potential Anti-tumor Agent

Gliomas are the most common primary brain tumors with a usually fatal malignancy. They are associated with a poor prognosis although multiple therapeutic options have been available. Trimebutine is one of the prokinetic agents and it has been mainly used for treatment of disorders of the gastrointestinal (GI) tract such as irritable bowel syndrome. However, its effects on glioma cells remain unknown. Here, we used various concentrations of trimebutine to treat SHG44, U251, and U-87 MG human glioma/glioblastoma cells. And combined experiments of MTT, colony formation assay, and wound healing assay, as well as western blot and immunofluorescence staining were used to evaluate the effects of trimebutine on glioma cells. The results demonstrated that trimebutine significantly inhibited cell viability and colony formation. A significant inhibition of glioma cell migration was also indicated by wound healing assay. In addition, trimebutine promoted cell apoptosis and induced Bcl-2 downregulation, accompanied with Bax upregulation. Both immunofluorescence staining and western blot results showed that trimebutine increased the level of active Caspase-3. Moreover, trimebutine reduced the activation of both AKT and ERK signaling pathways. In subcutaneous U-87 MG cell xenograft tumors in nude mice, trimebutine significantly inhibited tumor growth. More TUNEL-positive apoptotic cells in tumor sections were observed in trimebutine-treated mice when compared to the vehicle control. Reduced Bcl-2 and upregulated Bax, as well as perturbed p-AKT and p-ERK signaling pathways were also observed in trimebutine-treated xenograft tissues. Our combined data indicated that trimebutine may be potentially applied for the clinical management of glioma/glioblastoma

Acute Respiratory Distress Syndrome Induced by a Swine 2009 H1N1 Variant in Mice

Background: Acute respiratory distress syndrome (ARDS) induced by pandemic 2009 H1N1 influenza virus has been widely reported and was considered the main cause of death in critically ill patients with 2009 H1N1 infection. However, no animal model has been developed for ARDS caused by infection with 2009 H1N1 virus. Here, we present a mouse model of ARDS induced by 2009 H1N1 virus. Methodology Principal Findings: Mice were inoculated with A/swine/Shandong/731/2009 (SD/09), which was a 2009 H1N1 influenza variant with a G222D mutation in the hemagglutinin. Clinical symptoms were recorded every day. Lung injury was assessed by lung water content and histopathological observation. Arterial blood gas, leukocyte count in the bronchial alveolar lavage fluid and blood, virus titers, and cytokine levels in the lung were measured at various times post-inoculation. Mice infected with SD/09 virus showed typical ARDS symptoms characterized by 60 % lethality on days 8–10 postinoculation, highly edematous lungs, inflammatory cellular infiltration, alveolar and interstitial edema, lung hemorrhage, progressive and severe hypoxemia, and elevated levels of proinflammatory cytokines and chemokines. Conclusions/Significance: These results suggested that we successfully established an ARDS mouse model induced by a virulent 2009 H1N1 variant without previous adaptation, which may be of benefit for evaluating the pathogenesis or therapy of human ARDS caused by 2009 H1N1 virus

Bioinspired Designs and Biomimetic Applications of Triboelectric Nanogenerators

The emerging novel power generation technology of triboelectric nanogenerators (TENGs) is attracting increasing attention due to its unlimited prospects in energy harvesting and self-powered sensing applications. The most important factors that determine TENGs’ electrical and mechanical performance include the device structure, surface morphology and the type of triboelectric material employed, all of which have been investigated in the past to optimize and enhance the performance of TENG devices. Amongst them, bioinspired designs, which mimic structures, surface morphologies, material properties and sensing/power generation mechanisms from nature, have largely benefited in terms of enhanced performance of TENGs. In addition, a variety of biomimetic applications based on TENGs have been explored due to the simple structure, self-powered property and tunable output of TENGs. In this review article, we present a comprehensive review of various researches within the specific focus of bioinspired TENGs and TENG enabled biomimetic applications. The review begins with a summary of the various bioinspired TENGs developed in the past with a comparative analysis of the various device structures, surface morphologies and materials inspired from nature and the resultant improvement in the TENG performance. Various ubiquitous sensing principles and power generation mechanisms in use in nature and their analogous artificial TENG designs are corroborated. TENG-enabled biomimetic applications in artificial electronic skins and neuromorphic devices are discussed. The paper concludes by providing a perspective towards promising directions for future research in this burgeoning field of study

The association between socioeconomic status and traditional chinese medicine use among children in Taiwan

<p>Abstract</p> <p>Background</p> <p>Traditional Chinese medicine (TCM) utilization is common in Asian countries. Limited studies are available on the socioeconomic status (SES) associated with TCM use among the pediatric population. We report on the association between SES and TCM use among children and adolescents in Taiwan.</p> <p>Methods</p> <p>A National Health Interview Survey was conducted in Taiwan in 2001 that included 5,971 children and adolescents. We assessed the children's SES using the head of household's education, occupation and income. This information was used to calculate pediatric SES scores, which in turn were divided into quartiles. Children and adolescents who visited TCM in the past month were defined as TCM users.</p> <p>Results</p> <p>Compared to children in the second SES quartile, children in the fourth SES quartile had a higher average number of TCM visits (0.12 vs. 0.06 visits, p = 0.027) and higher TCM use prevalence (5.0% vs. 3.6%, p = 0.024) within the past month. The adjusted odds ratio (OR) for TCM use was higher for children in the fourth SES quartile than for those in the first SES quartile (OR 1.49; 95% confidence interval [CI] 1.02-2.17). The corresponding OR was 2.17 for girls (95% CI 1.24-3.78). The highest-SES girls (aged 10-18 years) were most likely to visit TCM practices (OR 2.47; 95% CI 1.25-4.90).</p> <p>Conclusions</p> <p>Children and adolescents with high SES were more likely to use TCM and especially girls aged 10-18 years. Our findings point to the high use of complementary and alternative medicine among children and adolescents.</p