The therapeutic evaluation and mechanism on treating bronchial hyper-responsiveness cough by ziyinqingre prescription

Objective: Discussing the effects of Ziyinqingre prescription on the level of airway resistance (Rrs), airway response threshold (Dmin), airway conductance (sGrs) and the level of inflammatory cytokines interleukin-4 (IL-4) and interferon-γ (IFN-γ) of the bronchial hyper-responsiveness (BHR) cough patients.Method: 84 subjects diagnosed as BHR were randomly divided into 42 Chinese Traditional medicine group and 42 control group. The Chinese Traditional Medicine group received Ziyinqingre prescription twice a day and the control group received 10mg Montelukast Sodium tablets once a day for two weeks. Observe the clinical symptoms improvement and the changes of the level of the Rrs, Dmin, sGrs and IL-4, IFN-γ.Results: After receiving the medicine, the symptoms of the Chinese medicine group were obviously alleviated, the outcome was more satisfied than that of the control group. Compared with the control group, the level of Dmin increased and sGrs level decreased more obviously (P<0.05); the level of IL-4 decreased and IFN-γlevel increased more obviously in the Chinese medicine group (P<0.05).Conclusion: Ziyinqingre prescription can not only improve BHR patients’ symptoms, but reduce the level of bronchial responsiveness, which proved a better curative effect of Chinese medicine. The mechanism is probably due to relieving the airway inflammation by keeping the balance between Th1 and Th2 cells.Keywords: Ziyinqingre prescription; cough; bronchial hyper-responsiveness; therapeutic mechanis

The exploration on “Three-mode and One-line” heuristic teaching in the clinical teaching

探讨“三模一线”启发式教学在医学临床教学中的应用。充分发挥LBL(Lecture-Based Learning)、PBL(Problem-Based Learning)和CBL(Case- Based Learning)三种教学模式的优点，互相弥补不足，按照临床实践-理论总结-再到临床实践的这条主线，充分调动学生的积极性、主动性和创造性，促进学生密切联系临床实际，激发学生思考和解决问题等实践能力的培养，利于培养理论、实践技能兼备的高素质医学人才。To explore "Three-mode and One-line" heuristic teaching in clinical teaching. Using the three teaching modes including LBL (Lecture -based Learning), PBL (Problem -based Learning) and CBL (Case - -based Learning) in teaching activities ,which full played their advantages and compensated each other according to a common thread of clinical practice - theoretical summary - clinical practice. We fully mobilized students' enthusiasm, initiative and creativity to promote students theory closely into related clinical practice, stimulated students to think and solve problems such as the cultivation of practice ability. It is good for training high-quality medical personnel both in theory and practice skills

An agent-based spatiotemporal integrated approach to simulating in-home water and related energy use behaviour: A test case of Beijing, China

Water and energy consumptions in the residential sector are highly correlated. A better understanding of the correlation would help save both water and energy, for example, through technological innovations, management and policies. Recently, there is an increasing need for a higher spatiotemporal resolution in the analysis and modelling of water-energy demand, as the results would be more useful for policy analysis and infrastructure planning in both water and energy systems. In response, this paper developed an agent-based spatiotemporal integrated approach to simulate the water-energy consumption of each household or person agent in second throughout a whole day, considering the influences of out-of-home activities (e.g., work and shopping) on in-home activities (e.g., bathing, cooking and cleaning). The integrated approach was tested in the capital of China, Beijing. The temporal results suggested that the 24-hour distributions of water and related energy consumptions were quite similar, and the water-energy consumptions were highly correlated (with a Pearson correlation coefficient of 0.89); The spatial results suggested that people living in the central districts and the central areas of the outer districts tended to consume more water and related energy, and also the water-energy correlation varies across space. Such spatially and temporally explicit results are expected to be useful for policy making (e.g., time-of-use tariffs) and infrastructure planning and optimization in both water and energy sectors

Research Progress on Ferroptosis as a Therapeutic Strategy in Renal Cell Carcinoma

Renal cell carcinoma (RCC) is a common type of kidney cancer in adults and constitutes approximately 90% of all renal malignancies. Although advancements have been made in the treatment of RCC, the 5 -year survival rate is still low, and new treatment modalities are still required. Ferroptosis is an iron-dependent programmed cell death caused by the accumulation of lipid peroxide products. Recent studies revealed the involvement of ferroptosis metabolism, lipid peroxidation, and System XC-GSH-GPX4 shafts as major mechanisms closely related to RCC progression. Nanoparticles in combination with small molecular ferroptosis induction agents have the advantages of solubility, targeted enhancement, low systemic toxicity, controllable drug control, and synergy advantage in emerging combination therapies. In the future, it is possible to be used in nano treatment. The relationship between ferroptosis-related mechanisms and RCC progression and its role in the treatment could provide novel treatment strategies for patients with advance-stage RCC

Diagnosis Analysis of 4 TCM Patterns in Suboptimal Health Status: A Structural Equation Modelling Approach

Background. We illustrated an example of structure equation modelling (SEM) in the research on SHS to explore the diagnosis of the Sub optimal health status (SHS) and provide evidence for the standardization of traditional Chinese medicine (TCM) patterns in SHS. And the diagnosis of 4 TCM patterns in SHS was evaluated in this analysis. Methods. This study assessed data on 2807 adults (aged 18 to 49) with SHS from 6 clinical centres. SEM was used to analyze the patterns of SHS in TCM. Parameters in the introduced model were estimated by the maximum likelihood method. Results. The discussed model fits the SHS data well with CFI = 0.851 and RMSEA = 0.075. The direct effect of Qi deficiency pattern on dampness pattern had the highest magnitude (value of estimate is 0.822). With regard to the construct of “Qi deficiency pattern”, “fire pattern”, “stagnation pattern” and “dampness pattern”, the indicators with the highest load were myasthenia of limbs, vexation, deprementia, and dizziness, respectively. It had been shown that estimate factor should indicate the important degree of different symptoms in pattern. Conclusions. The weights of symptoms in the respective pattern can be statistical significant and theoretical meaningful for the 4 TCM patterns identification in SHS research. The study contributed to a theoretical framework, which has implications for the diagnosis points of SHS