A rare complication in a child undergoing chemotherapy for acute lymphoblastic leukemia: Superior sagittal sinus thrombosis

AbstractWe report the case of a 4-year-old boy with acute lymphoblastic leukemia in high-risk group who suffered from generalized tonic-colonic seizure evolving into status epilepticus, and subsequent left hemiparesis during his first reinduction chemotherapy, consisting of dexamethasone, vincristine, l-asparaginase, and epirubicin. Superior sagittal sinus and cerebral venous thrombosis, predominantly in right side, were proved by brain magnetic resonance imaging. After aggressive treatment with low-molecular weight heparin (LMWH), left hemiparesis improved in 1 week. And he was fully ambulatory 3 weeks later. The second cycle of reinduction chemotherapy was conducted smoothly with the concomitant use of LMWH. This case illustrates the strong correlation of the rare thrombotic complication, superior sagittal sinus thrombosis, and hypercoagulable status secondary to combination use of l-asparaginase and corticosteroid. Early and vigilant recognition of superior sagittal sinus thrombosis and prompt anticoagulation with LMWH may prevent further neurological damage

KINEMATICS ANALYSIS OF THE UPPER EXTREMITY DURING THE TWOHANDED BACKHAND DRIVE VOLLEY FOR FEMALE TENNIS PLAYERS

The purpose of this study was to discuss the motion characteristics of the arms in the two-handed backhand drive volley. Five elite female tennis players participated in this study, their two-handed backhand drive volley strokes were analysed, and all participants are right handed. Motion Analysis System with 10 Eagle Digital inferred high speed cameras at 200Hz were used for this study. The results show a similar elbow and wrist speed strategy in x-axis between two-handed ground stroke and drive volley, our study also found that the rear arm dominates the stroke and mainly provide the topspin that is required for the skill of the drive volley. In order to create better stroke efficiency, the right elbow reached peak velocity first, followed by the right wrist before racket impact with the ball

GeneAlign: a coding exon prediction tool based on phylogenetical comparisons

GeneAlign is a coding exon prediction tool for predicting protein coding genes by measuring the homologies between a sequence of a genome and related sequences, which have been annotated, of other genomes. Identifying protein coding genes is one of most important tasks in newly sequenced genomes. With increasing numbers of gene annotations verified by experiments, it is feasible to identify genes in the newly sequenced genomes by comparing to annotated genes of phylogenetically close organisms. GeneAlign applies CORAL, a heuristic linear time alignment tool, to determine if regions flanked by the candidate signals (initiation codon-GT, AG-GT and AG-STOP codon) are similar to annotated coding exons. Employing the conservation of gene structures and sequence homologies between protein coding regions increases the prediction accuracy. GeneAlign was tested on Projector dataset of 491 human–mouse homologous sequence pairs. At the gene level, both the average sensitivity and the average specificity of GeneAlign are 81%, and they are larger than 96% at the exon level. The rates of missing exons and wrong exons are smaller than 1%. GeneAlign is a free tool available at

Properties of Lactobacillus reuteri chitosan-calcium-alginate encapsulation under simulated gastrointestinal conditions

The protective effects of encapsulation on the survival of Lactobacillus reuteri and the retention of the bacterium’s probiotic properties under simulated gastrointestinal conditions were investigated. Viable counts and the remaining probiotic properties of calcium (Ca)-alginate encapsulated (A group), chitosan-Ca-alginate encapsulated (CA group), and unencapsulated, free L. reuteri (F group) were determined. Encapsulation improved the survival of L. reuteri subjected to simulated gastrointestinal conditions, with the greatest protective effect achieved in the CA group. The degree of cell membrane injury increased with increasing bile salt concentrations at constant pH, but the extent of injury was less in the encapsulated than in the free cells. Adherence rates were, in descending order: CA (0.524%) > A (0.360%) > F (0.275%). Lactobacillus reuteri cells retained their antagonistic activity toward Listeria monocytogenes even after incubation of the lactobacilli under simulated gastrointestinal conditions. Displacement of the pathogen by cells released from either of the encapsulation matrices was higher than that by free cells. The safety of L. reuteri was demonstrated in an in vitro invasion assay. [Int Microbiol 2015; 18(1):61-69]Keywords: Lactobacillus reuteri · Listeria monocytogenes · chitosan–calcium-alginate encapsulation · probiotic properties · simulated gastrointestinal condition

An Efficient Generalizable Framework for Visuomotor Policies via Control-aware Augmentation and Privilege-guided Distillation

Visuomotor policies, which learn control mechanisms directly from high-dimensional visual observations, confront challenges in adapting to new environments with intricate visual variations. Data augmentation emerges as a promising method for bridging these generalization gaps by enriching data variety. However, straightforwardly augmenting the entire observation shall impose excessive burdens on policy learning and may even result in performance degradation. In this paper, we propose to improve the generalization ability of visuomotor policies as well as preserve training stability from two aspects: 1) We learn a control-aware mask through a self-supervised reconstruction task with three auxiliary losses and then apply strong augmentation only to those control-irrelevant regions based on the mask to reduce the generalization gaps. 2) To address training instability issues prevalent in visual reinforcement learning (RL), we distill the knowledge from a pretrained RL expert processing low-level environment states, to the student visuomotor policy. The policy is subsequently deployed to unseen environments without any further finetuning. We conducted comparison and ablation studies across various benchmarks: the DMControl Generalization Benchmark (DMC-GB), the enhanced Robot Manipulation Distraction Benchmark (RMDB), and a specialized long-horizontal drawer-opening robotic task. The extensive experimental results well demonstrate the effectiveness of our method, e.g., showing a 17\% improvement over previous methods in the video-hard setting of DMC-GB

AOB Nitrosospira cluster 3a.2 (D11) dominates N2O emissions in fertilised agricultural soils.

CRediT authorship contribution statement Na Deng: Writing – review & editing, Methodology, Investigation, Data curation. Cecile Gubry-Rangin: Writing – review & editing, Methodology, Conceptualization. Xiao-Tong Song: Writing – review & editing, Methodology, Data curation. Xiao-Tang Ju: Writing – review & editing, Conceptualization. Si-Yi Liu: Methodology, Data curation. Ju-Pei Shen: Writing – review & editing, Data curation. Hong-jie Di: Writing – review & editing. Li-Li Han: Writing – review & editing, Methodology. Li-Mei Zhang: Writing – review & editing, Methodology, Data curation, Conceptualization.Peer reviewe