NIR-emissive Alkynylplatinum(II) Terpyridyl Complex as a turn-on selective probe for heparin quantification by induced helical self-assembly behaviour

The extent of self-assembly viametal–metal and π-π stacking interactions, induced by the polyanionic biopolymers, enables the class of alkynylplatinum(II) terpyridyl complexes to be applicable for the sensing of important biomacromolecules through the monitoring of spectral changes. Strong demand arises for the design of selective and practical detection techniques for the quantification of heparin, a highly negative-charged polysaccharidethat can function as anticoagulant, due to the prevention of hemorrhagic complications upon overdose usage.Aconvenient sensing protocol for the detection of UFH and LMWH, two common forms of heparins in clinical use, in buffer and biological medium has been demonstrated with the spectral changes associated with the induced self-assembly of a NIR-emissive platinum(II) complex. The detection range has been demonstrated to cover clinical dosage levels and the structurally similar analogues can be effectively differentiated based on their anionic charge density and the formation of supramolecular helical assembly of the platinum(II) complex with them ...postprin

Microcosm, Tillich & Tao : a critique of Tillich's ontology

This thesis is a critique of Paul Tillich's ontology. It demonstrates inconsistency in Tillich's theological system, exposed by the microcosmic/macrocosmic theme, implicit in his theology. The thesis suggests that Tillich intuited the relationship between God and humanity in microcosmic/macrocosmic terms, but his tightly reasoned arguments stifled the intuition, causing the microcosmic theme to remain hidden under the more explicit concerns of his system. The thesis establishes the powerful microcosmic theme underlying Tillich's system, in which creaturely life is imbued with the Principles of divine life. This intimacy, coupled with inconsistency in Tillich's theology with regard to human freedom and estrangement, generates doubt about Tillich's assertion that creaturely estrangement from its divine ground is ontological in nature. In view of the fact that separation and estrangement are not merely idiosyncratic of Tillichian thought, but are entrenched in the western Christian tradition, the thesis looks outside that tradition to assess the validity of Tillich's claim with respect to the ontological nature of estrangement. To this end, the Chinese tradition is engaged, in order to ascertain the extent to which estrangement features in the ontology pertaining to a principal theme in that tradition, the Tao. In its exploration of the Tao through the two texts of the Lao Tzu and the Chuang Tzu, the thesis notes the absence of the theme of estrangement. In light of this, Tillich's insistence upon the ontological nature of estrangement is challenged on the grounds that if estrangement is truly ontological, it will be so for the whole of humankind, not solely for one particular tradition. Having shown Tillich's ontological assumption to be questionable, the thesis proceeds to consider the impact of the removal of the theme of estrangement from his system. It demonstrates that its removal not only permits the implicit microcosmic theme to be brought to the fore, but also transforms his theology from one based upon dualistic consciousness, with the inherent tensions and ambiguities that such awareness inevitably creates, to one based upon integration and holism. The thesis does not seek to offer a comparative study of the ontologies pertaining to Tillich and the Tao. Rather, it utilises the Tao as the means by which the researcher looks beyond Tillichian theology and the western tradition in which it was entrenched, in order to return to that theology with fresh insight. This is in accord with Tillich's own method of correlation, where he engages with that which lies beyond the finite creature, in order to gain fuller understanding of the nature of that creature

Anion Binding Properties of Alkynylplatinum(II) Complexes with Amide-Functionalized Terpyridine: Host-Guest Interactions and Fluoride Ion-Induced Deprotonation

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Will oil price crash destabilize petro-states? : a study of oil price crashes in 1985-1986 and 2014-2015 and the impacts on the political stability of petro-states : Venezuela, Algeria, the Soviet Union/Russia, Saudi Arabia and Indonesia

published_or_final_versionInternational and Public AffairsMasterMaster of International and Public Affair

Novel RhoGAP independent pathway of tumor suppressor DLC1 regulates cancer invasion and metastasis

This journal suppl. entitled: Proceedings: AACR Annual Meeting 2014; April 5-9, 2014 ...Molecular and Cellular Biology - Poster Presentations - Proffered Abstracts - Poster Presentations - Tumor Suppressors 2: abstract no. 1565Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. Deleted in Liver Cancer 1 (DLC1) is a tumor suppressor gene critically involved in hepatocarcinogenesis. DLC1 is a Rho GTPase activating protein (RhoGAP), which serves as the negative regulator of Rho proteins. Rho proteins are important in remodeling of actin cytoskeleton, transcription regulation, cell proliferation, tumorigenesis and metastasis. Apart from RhoGAP activity, the inhibitory activity of DLC1 is also dependent on its proper focal adhesion localization. It has been found that tensin proteins are responsible for directing DLC1 to the focal adhesions via their interaction which is important to the tumor suppression activity of DLC1. Recently, we identified that ...postprin

Supramolecular assembly of platinum-containing polyhedral oligomeric silsesquioxanes: an interplay of intermolecular interactions and a correlation between structural modifications and morphological transformations

published_or_final_versio

Curriculum Design of Artificial Intelligence and Sustainability in Secondary School

Artificial Intelligence is revolutionizing numerous sectors with its transformative power, while at the same time, there is an increasing sense of urgency to address sustainability challenges. Despite the significance of both areas, secondary school curriculums still lack comprehensive integration of AI and sustainability education. This paper presents a curriculum designed to bridge this gap. The curriculum integrates progressive objectives, computational thinking competencies and system thinking components across five modules—awareness, knowledge, interaction, empowerment and ethics—to cater to varying learner levels. System thinking components help students understand sustainability in a holistic manner. Computational thinking competencies aim to cultivate computational thinkers to guide the design of curriculum activities

Autonomous frequency domain identification: Theory and experiment

The analysis, design, and on-orbit tuning of robust controllers require more information about the plant than simply a nominal estimate of the plant transfer function. Information is also required concerning the uncertainty in the nominal estimate, or more generally, the identification of a model set within which the true plant is known to lie. The identification methodology that was developed and experimentally demonstrated makes use of a simple but useful characterization of the model uncertainty based on the output error. This is a characterization of the additive uncertainty in the plant model, which has found considerable use in many robust control analysis and synthesis techniques. The identification process is initiated by a stochastic input u which is applied to the plant p giving rise to the output. Spectral estimation (h = P sub uy/P sub uu) is used as an estimate of p and the model order is estimated using the produce moment matrix (PMM) method. A parametric model unit direction vector p is then determined by curve fitting the spectral estimate to a rational transfer function. The additive uncertainty delta sub m = p - unit direction vector p is then estimated by the cross spectral estimate delta = P sub ue/P sub uu where e = y - unit direction vectory y is the output error, and unit direction vector y = unit direction vector pu is the computed output of the parametric model subjected to the actual input u. The experimental results demonstrate the curve fitting algorithm produces the reduced-order plant model which minimizes the additive uncertainty. The nominal transfer function estimate unit direction vector p and the estimate delta of the additive uncertainty delta sub m are subsequently available to be used for optimization of robust controller performance and stability

Transformable Nanostructures of Luminescent Platinum-Containing Organosilane Hybrids: Non-Covalent Self- Assembly of Polyhedral Oligomeric Silsesquioxanes Assisted by Pt···Pt and π–π Stacking Interactions of Alkynylplatinum(II) Terpyridine Moieties

Poster Presentation: S9- Supramolecular Chemistry and Self-Assembly - no. S9.P