5,327 research outputs found
Coarsening Dynamics of a One-Dimensional Driven Cahn-Hilliard System
We study the one-dimensional Cahn-Hilliard equation with an additional
driving term representing, say, the effect of gravity. We find that the driving
field has an asymmetric effect on the solution for a single stationary
domain wall (or `kink'), the direction of the field determining whether the
analytic solutions found by Leung [J.Stat.Phys.{\bf 61}, 345 (1990)] are
unique. The dynamics of a kink-antikink pair (`bubble') is then studied. The
behaviour of a bubble is dependent on the relative sizes of a characteristic
length scale , where is the driving field, and the separation, ,
of the interfaces. For the velocities of the interfaces are
negligible, while in the opposite limit a travelling-wave solution is found
with a velocity . For this latter case () a set of
reduced equations, describing the evolution of the domain lengths, is obtained
for a system with a large number of interfaces, and implies a characteristic
length scale growing as . Numerical results for the domain-size
distribution and structure factor confirm this behavior, and show that the
system exhibits dynamical scaling from very early times.Comment: 20 pages, revtex, 10 figures, submitted to Phys. Rev.
Perceived stigmatisation of patients with mental illness and its psychosocial correlates: a prospective cohort study
Dynamics of Ordering of Heisenberg Spins with Torque --- Nonconserved Case. I
We study the dynamics of ordering of a nonconserved Heisenberg magnet. The
dynamics consists of two parts --- an irreversible dissipation into a heat bath
and a reversible precession induced by a torque due to the local molecular
field. For quenches to zero temperature, we provide convincing arguments, both
numerically (Langevin simulation) and analytically (approximate closure scheme
due to Mazenko), that the torque is irrelevant at late times. We subject the
Mazenko closure scheme to systematic numerical tests. Such an analysis, carried
out for the first time on a vector order parameter, shows that the closure
scheme performs respectably well. For quenches to , we show, to , that the torque is irrelevant at the Wilson-Fisher fixed
point.Comment: 13 pages, REVTEX, and 19 .eps figures, compressed, Submitted to Phys.
Rev.
Development of the multi-attribute Adolescent Health Utility Measure (AHUM)
Objective
Obtain utilities (preferences) for a generalizable set of health states experienced by older children and adolescents who receive therapy for chronic health conditions.
Methods
A health state classification system, the Adolescent Health Utility Measure (AHUM), was developed based on generic health status measures and input from children with Hunter syndrome and their caregivers. The AHUM contains six dimensions with 4–7 severity levels: self-care, pain, mobility, strenuous activities, self-image, and health perceptions. Using the time trade off (TTO) approach, a UK population sample provided utilities for 62 of 16,800 AHUM states. A mixed effects model was used to estimate utilities for the AHUM states. The AHUM was applied to trial NCT00069641 of idursulfase for Hunter syndrome and its extension (NCT00630747).
Results
Observations (i.e., utilities) totaled 3,744 (12*312 participants), with between 43 to 60 for each health state except for the best and worst states which had 312 observations. The mean utilities for the best and worst AHUM states were 0.99 and 0.41, respectively. The random effects model was statistically significant (p < 0.0001; adjusted R2 = 0.361; RMSE = 0.194). When AHUM utilities were applied to the idursulfase trial, mean utilities in the idursulfase weekly and placebo groups improved +0.087 and +0.006, respectively, from baseline to week 53. In the extension, when all patients received idursulfase, the utilities in the treatment group remained stable and the placebo group improved +0.039.
Discussion
The AHUM health state classification system may be used in future research to enable calculation of quality-adjust life expectancy for applicable health conditions
Measurement of Lagrangian velocity in fully developed turbulence
We have developed a new experimental technique to measure the Lagrangian
velocity of tracer particles in a turbulent flow, based on ultrasonic Doppler
tracking. This method yields a direct access to the velocity of a single
particule at a turbulent Reynolds number . Its dynamics is
analyzed with two decades of time resolution, below the Lagrangian correlation
time. We observe that the Lagrangian velocity spectrum has a Lorentzian form
, in agreement
with a Kolmogorov-like scaling in the inertial range. The probability density
function (PDF) of the velocity time increments displays a change of shape from
quasi-Gaussian a integral time scale to stretched exponential tails at the
smallest time increments. This intermittency, when measured from relative
scaling exponents of structure functions, is more pronounced than in the
Eulerian framework.Comment: 4 pages, 5 figures. to appear in PR
Anxiety and depression with neurogenesis defects in exchange protein directly activated by cAMP 2-deficient mice are ameliorated by a selective serotonin reuptake inhibitor, Prozac
Intracellular cAMP and serotonin are important modulators of anxiety and depression. Fluoxetine, a selective serotonin reuptake inhibitor (SSRI) also known as Prozac, is widely used against depression, potentially by activating cAMP response element-binding protein (CREB) and increasing brain-derived neurotrophic factor (BDNF) through protein kinase A (PKA). However, the role of Epac1 and Epac2 (Rap guanine nucleotide exchange factors, RAPGEF3 and RAPGEF4, respectively) as potential downstream targets of SSRI/cAMP in mood regulations is not yet clear. Here, we investigated the phenotypes of Epac1 (Epac1− / −) or Epac2 (Epac2− / −) knockout mice by comparing them with their wild-type counterparts. Surprisingly, Epac2− / − mice exhibited a wide range of mood disorders, including anxiety and depression with learning and memory deficits in contextual and cued fear-conditioning tests without affecting Epac1 expression or PKA activity. Interestingly, rs17746510, one of the three single-nucleotide polymorphisms (SNPs) in RAPGEF4 associated with cognitive decline in Chinese Alzheimer’s disease (AD) patients, was significantly correlated with apathy and mood disturbance, whereas no significant association was observed between RAPGEF3 SNPs and the risk of AD or neuropsychiatric inventory scores. To further determine the detailed role of Epac2 in SSRI/serotonin/cAMP-involved mood disorders, we treated Epac2− / − mice with a SSRI, Prozac. The alteration in open field behavior and impaired hippocampal cell proliferation in Epac2− / − mice were alleviated by Prozac. Taken together, Epac2 gene polymorphism is a putative risk factor for mood disorders in AD patients in part by affecting the hippocampal neurogenesis.published_or_final_versio
Temporal Effects of Agent Aggregation in the Dynamics of Multiagent Systems
We propose a model of multiagent systems whose agents have a tendency to
balance their decisions in time. We find phase transitions to oscillatory
behavior, explainable by the aggregation of agents into two groups. On a longer
time scale, we find that the aggregation of smart agents is able to explain the
lifetime distribution of epochs to 8 decades of probability.Comment: 7 pages, 5 figure
Phase Separation Kinetics in a Model with Order-Parameter Dependent Mobility
We present extensive results from 2-dimensional simulations of phase
separation kinetics in a model with order-parameter dependent mobility. We find
that the time-dependent structure factor exhibits dynamical scaling and the
scaling function is numerically indistinguishable from that for the
Cahn-Hilliard (CH) equation, even in the limit where surface diffusion is the
mechanism for domain growth. This supports the view that the scaling form of
the structure factor is "universal" and leads us to question the conventional
wisdom that an accurate representation of the scaled structure factor for the
CH equation can only be obtained from a theory which correctly models bulk
diffusion.Comment: To appear in PRE, figures available on reques
Co-axial dual-core resonant leaky fibre for optical amplifiers
We present a co-axial dual-core resonant leaky optical fibre design, in which
the outer core is made highly leaky. A suitable choice of parameters can enable
us to resonantly couple power from the inner core to the outer core. In a
large-core fibre, such a resonant coupling can considerably increase the
differential leakage loss between the fundamental and the higher order modes
and can result in effective single-mode operation. In a small-core single-mode
fibre, such a coupling can lead to sharp increase in the wavelength dependent
leakage loss near the resonant wavelength and can be utilized for the
suppression of amplified spontaneous emission and thereby gain equalization of
an optical amplifier. We study the propagation characteristics of the fibre
using the transfer matrix method and present an example of each, the
large-mode-area design for high power amplifiers and the wavelength tunable
leakage loss design for inherent gain equalization of optical amplifiers.Comment: 6 page
The identification of mitochondrial DNA variants in glioblastoma multiforme
Background:
Mitochondrial DNA (mtDNA) encodes key proteins of the electron transfer chain (ETC), which produces ATP through oxidative phosphorylation (OXPHOS) and is essential for cells to perform specialised functions. Tumor-initiating cells use aerobic glycolysis, a combination of glycolysis and low levels of OXPHOS, to promote rapid cell proliferation and tumor growth. Glioblastoma multiforme (GBM) is an aggressively malignant brain tumor and mitochondria have been proposed to play a vital role in GBM tumorigenesis.
Results:
Using next generation sequencing and high resolution melt analysis, we identified a large number of mtDNA variants within coding and non-coding regions of GBM cell lines and predicted their disease-causing potential through in silico modeling. The frequency of variants was greatest in the D-loop and origin of light strand replication in non-coding regions. ND6 was the most susceptible coding gene to mutation whilst ND4 had the highest frequency of mutation. Both genes encode subunits of complex I of the ETC. These variants were not detected in unaffected brain samples and many have not been previously reported. Depletion of HSR-GBM1 cells to varying degrees of their mtDNA followed by transplantation into immunedeficient mice resulted in the repopulation of the same variants during tumorigenesis. Likewise, de novo variants identified in other GBM cell lines were also incorporated. Nevertheless, ND4 and ND6 were still the most affected genes. We confirmed the presence of these variants in high grade gliomas.
Conclusions:
These novel variants contribute to GBM by rendering the ETC. partially dysfunctional. This restricts metabolism to anaerobic glycolysis and promotes cell proliferation
- …