Double Deep-Q Learning-Based Output Tracking of Probabilistic Boolean Control Networks

In this article, a reinforcement learning (RL)-based scalable technique is presented to control the probabilistic Boolean control networks (PBCNs). In particular, a double deep- $Q$ network (DD $Q\text{N}$ ) approach is firstly proposed to address the output tracking problem of PBCNs, and optimal state feedback controllers are obtained such that the output of PBCNs tracks a constant as well as a time-varying reference signal. The presented method is model-free and offers scalability, thereby provides an efficient way to control large-scale PBCNs that are a natural choice to model gene regulatory networks (GRNs). Finally, three PBCN models of GRNs including a 16-gene and 28-gene networks are considered to verify the presented results

An Optimal Decision Support System Based on Crop Dynamic Model for N-Fertilizer Treatment

The efficient handling of nitrogen has become a critical issue in modern agriculture, from a financial standpoint, as well as in regard to reducing the environmental impacts of using an excessive amount of nitrogen fertilizer. Manure compost is useful for maintaining or raising soil chemical levels without excessive NO3− accumulation; however, for the best grain yield, it should be combined with N fertilizer. Via this study, we aimed to develop an optimal decision support system that indicates when to initiate fertilization based on nitrogen-limited (N-limited) crop growth dynamics. An optimal nitrogen fertilizer (N-fertilizer) management system increases crop yield while maintaining a balance between fertilizer supply and crop demand. This study used the N-limited crop growth model (LINTUL3) to develop an optimal decision support system. In this work, we formulated and resolved two optimization challenges: (i) maximization of biomass growth; and (ii) maximization of growth with the least cost paid on N-fertilizer and its application. Furthermore, two case studies were developed based on the number of fields: (i) optimization for a single field, and (ii) optimization for multiple fields. In the case of multiple fields, it is hypothesized that a fertilizer treatment for one field can leak to other fields and affect the nitrogen dynamics of different fields. Finally, numerical simulations were carried out supporting the theory developed in the paper. The simulations showed that when the proposed work was employed to achieve the goal of optimal nitrogen management for a crop, a 28% to 53% increase in biomass growth under certain scenarios was attained

A Bibliometric Review of the Use of Unmanned Aerial Vehicles in Precision Agriculture and Precision Viticulture for Sensing Applications

This review focuses on the use of unmanned aerial vehicles (UAVs) in precision agriculture, and specifically, in precision viticulture (PV), and is intended to present a bibliometric analysis of their developments in the field. To this aim, a bibliometric analysis of research papers published in the last 15 years is presented based on the Scopus database. The analysis shows that the researchers from the United States, China, Italy and Spain lead the precision agriculture through UAV applications. In terms of employing UAVs in PV, researchers from Italy are fast extending their work followed by Spain and finally the United States. Additionally, the paper provides a comprehensive study on popular journals for academicians to submit their work, accessible funding organizations, popular nations, institutions, and authors conducting research on utilizing UAVs for precision agriculture. Finally, this study emphasizes the necessity of using UAVs in PV as well as future possibilities

A Bibliometric Review of the Use of Unmanned Aerial Vehicles in Precision Agriculture and Precision Viticulture for Sensing Applications

This review focuses on the use of unmanned aerial vehicles (UAVs) in precision agriculture, and specifically, in precision viticulture (PV), and is intended to present a bibliometric analysis of their developments in the field. To this aim, a bibliometric analysis of research papers published in the last 15 years is presented based on the Scopus database. The analysis shows that the researchers from the United States, China, Italy and Spain lead the precision agriculture through UAV applications. In terms of employing UAVs in PV, researchers from Italy are fast extending their work followed by Spain and finally the United States. Additionally, the paper provides a comprehensive study on popular journals for academicians to submit their work, accessible funding organizations, popular nations, institutions, and authors conducting research on utilizing UAVs for precision agriculture. Finally, this study emphasizes the necessity of using UAVs in PV as well as future possibilities

Auto-regulation of Secretory Flux by Sensing and Responding to the Folded Cargo Protein Load in the Endoplasmic Reticulum

Maintaining the optimal performance of cell processes and organelles is the task of auto-regulatory systems. Here we describe an auto-regulatory device that helps to maintain homeostasis of the endoplasmic reticulum (ER) by adjusting the secretory flux to the cargo load. The cargo-recruiting subunit of the coatomer protein II (COPII) coat, Sec24, doubles as a sensor of folded cargo and, upon cargo binding, acts as a guanine nucleotide exchange factor to activate the signaling protein G\u3b112 at the ER exit sites (ERESs). This step, in turn, activates a complex signaling network that activates and coordinates the ER export machinery and attenuates proteins synthesis, thus preventing large fluctuations of folded and potentially active cargo that could be harmful to the cell or the organism. We call this mechanism AREX (autoregulation of ER export) and expect that its identification will aid our understanding of human physiology and diseases that develop from secretory dysfunction. By sensing the load of folded ER lumenal proteins, the COPII subunit Sec24 directs a signaling cascade that allows secretory pathway flux to respond to the abundance of cargo