Adsorptive Removal of a Pharmaceutical and Personal Care Product Oxybenzone from Water with Metal-Organic Frameworks

Oxybenzone, one of the most often detected pharmaceuticals and personal care products (PPCPS), from aqueous solutions and this PPCPs removal from water had been studied by using the highly porous metal-organic framework (MOF) ) MIL-101(Cr) and a modified MIL-101(Cr) called MIL-101-OH. Adsorption results showed that MIL-101-OH which contains functional group such as –OH, which was very effective for oxybenzone adsorption. The adsorption performance of MIL-101-OH over MIL-101-OH was found to be greater than that of MIL-101(Cr), which means the functionalization of primitive MOFs have a positive effect on adsorption. The kinetics of MIL-101-OH also showed higher result compare to MIL-101(Cr). So along with a high adsorption capacity and repaid adsorption which is important for commercial applications

Activation of spleen tyrosine kinase is required for TNF-α-induced endothelin-1 upregulation in human aortic endothelial cells

AbstractEndothelin-1 (ET-1) promotes atherosclerosis. We tested whether spleen tyrosine kinase (Syk) mediates tumor necrosis factor-α (TNF-α)-induced ET-1 upregulation in human aortic endothelial cells (HAECs) and sought to identify the signal pathways involved. TNF-α-induced reactive oxygen species (ROS) activated Syk and phosphatidylinositol 3-kinase (PI3K), which was required for the activation of AP-1 and subsequent ET-1 gene transcription. ROS mediated c-Jun NH2-terminal kinase (JNK) is also required for AP-1 activation, but Syk and PI3K regulated AP-1 activation independently of JNK. Through regulation of ET-1 production, Syk could be implicated in atherosclerosis

A search for exoplanets around north circumpolar stars. VII. Detection of planetary companion orbiting the largest host star HD 18438

We have been conducting a exoplanet search survey using Bohyunsan Observatory Echelle Spectrograph (BOES) for the last 18 years. We present the detection of exoplanet candidate in orbit around HD 18438 from high-precision radial velocity (RV) mesurements. The target was already reported in 2018 (Bang et al. 2018). They conclude that the RV variations with a period of 719 days are likely to be caused by the pulsations because the Lomb-Scargle periodogram of HIPPARCOS photometric and Ha EW variations for HD 18438 show peaks with periods close to that of RV variations and there were no correlations between bisectors and RV measurements. However, the data were not sufficient to reach a firm conclusion. We obtained more RV data for four years. The longer time baseline yields a more accurate determination with a revised period of 803 +/- 5 days and the planetary origin of RV variations with a minimum planetary companion mass of 21 +/- 1 MJup. Our current estimate of the stellar parameters for HD 18438 makes it currently the largest star with a planetary companion.Comment: 6 pages, 4 figures, Accept to the Journal of the Korean Astronomical Societ

Paradoxical response during antituberculous therapy in a patient discontinuing infliximab: a case report

This is an Open Access article distributed under the terms of the Creative Commons Attribution Licens

Desmoplastic small round cell tumor of the stomach mimicking a gastric cancer in a child

Intra-abdominal desmoplastic small round cell tumor (DSRCT) is a highly malignant tumor of uncertain histogenesis. Here we report a case of DSRCT involving the stomach, initially misdiagnosed as gastric cancer. A 12-year-old boy presented with upper abdominal pain developed 1 month prior. On gastroscopy, a 7-cm mass was noted involving the esophago-gastric junction to the fundus, and positron emission tomography showed multiple hot uptakes suggesting distant metastasis. Gastroscopic biopsy showed poorly differentiated malignant cells. We diagnosed as stage IV gastric cancer and treated with 6 cycles of chemotherapy. Laparotomy revealed a huge gastric mass along with peritoneal disseminations. Palliative proximal gastrectomy was performed. Pathological examination revealed transmural involvement of DSRCT, and t(11;22)(p12;q12) was demonstrated on fluorescence in situ hybridization test. The chemotherapeutic regimen was changed and the patient underwent 8 additional cycles of post-operative chemotherapy. The patient is now alive and the residual tumor shows no significant changes after chemotherapy

AKARI Detection of the Infrared-Bright Supernova Remnant B0104-72.3 in the Small Magellanic Cloud

We present a serendipitous detection of the infrared-bright supernova remnant (SNR) B0104-72.3 in the Small Magellanic Cloud by the Infrared Camera (IRC) onboard AKARI. An elongated, partially complete shell is detected in all four observed IRC bands covering 2.6-15 um. The infrared shell surrounds radio, optical, and X-ray emission associated with the SNR and is probably a radiative SNR shell. This is the first detection of a SNR shell in this near/mid-infrared waveband in the Small Magellanic Cloud. The IRC color indicates that the infrared emission might be from shocked H2 molecules with some possible contributions from ionic lines. We conclude that B0104-72.3 is a middle-aged SNR interacting with molecular clouds, similar to the Galactic SNR IC 443. Our results highlight the potential of AKARI IRC observations in studying SNRs, especially for diagnosing SNR shocks.Comment: 12 pages with 3 figures, accepted for publication in AKARI PASJ special issu

Gastric Yolk Sac Tumor: A Case Report and Review of the Literature

Gastric yolk sac tumors are extremely rare and their prognosis is poor; most patients have widespread metastases at the time of diagnosis. The treatment of gastric yolk sac tumors consists of aggressive chemotherapy combined with radiotherapy and surgery. Here, we first report a case of gastric yolk sac tumor presenting as an early gastric cancer that was cured after a gastrectomy with lymphadenectomy

Enzymatic properties of the Caenorhabditis elegans Dna2 endonuclease/helicase and a species-specific interaction between RPA and Dna2

In both budding and fission yeasts, a null mutation of the DNA2 gene is lethal. In contrast, a null mutation of Caenorhabditis elegans dna2(+) causes a delayed lethality, allowing survival of some mutant C.elegans adults to F2 generation. In order to understand reasons for this difference in requirement of Dna2 between these organisms, we examined the enzymatic properties of the recombinant C.elegans Dna2 (CeDna2) and its interaction with replication-protein A (RPA) from various sources. Like budding yeast Dna2, CeDna2 possesses DNA-dependent ATPase, helicase and endonuclease activities. The specific activities of both ATPase and endonuclease activities of the CeDna2 were considerably higher than the yeast Dna2 (∼10- and 20-fold, respectively). CeDna2 endonuclease efficiently degraded a short 5′ single-stranded DNA tail (<10 nt) that was hardly cleaved by ScDna2. Both endonuclease and helicase activities of CeDna2 were stimulated by CeRPA, but not by human or yeast RPA, demonstrating a species-specific interaction between Dna2 and RPA. These and other enzymatic properties of CeDna2 described in this paper may shed light on the observation that C.elegans is less stringently dependent on Dna2 for its viability than Saccharomyces cerevisiae. We propose that flaps generated by DNA polymerase δ-mediated displacement DNA synthesis are mostly short in C.elegans eukaryotes, and hence less dependent on Dna2 for viability