Holographic duals of M5-branes on an irregularly punctured sphere

We provide explicit holographic duals of M5-branes wrapped on a sphere with one irregular puncture and one regular puncture of arbitrary type. The solutions generalise the solutions corresponding to M5-branes wrapped on a disc recently constructed by Bah-Bonetti-Minasian-Nardoni by allowing for a general choice of regular puncture. We show that the central charges, flavour central charges and conformal dimensions of BPS operators match with a class of Argyres-Douglas theory

Thermodynamics of accelerating AdS4_4 black holes from the covariant phase space

We study the charges and first law of thermodynamics for accelerating, non-rotating black holes with dyonic charges in AdS$_4$ using the covariant phase space formalism. In order to apply the formalism to these solutions (which are asymptotically locally AdS and admit a non-smooth conformal boundary $\mathscr{I}$) we make two key improvements: 1) We relax the requirement to impose Dirichlet boundary conditions and demand merely a well-posed variational problem. 2) We keep careful track of the codimension-2 corner term induced by the holographic counterterms, a necessary requirement due to the presence of "cosmic strings" piercing $\mathscr{I}$. Using these improvements we are able to match the holographic Noether charges to the Wald Hamiltonians of the covariant phase space and derive the first law of black hole thermodynamics with the correct "thermodynamic length'' terms arising from the strings. We investigate the relationship between the charges imposed by supersymmetry and show that our first law can be consistently applied to various classes of non-supersymmetric solutions for which the cross-sections of the horizon are spindles.Comment: 42 pages, 1 figur

D4-branes wrapped on four-dimensional orbifolds through consistent truncation

We construct a consistent truncation of six-dimensional matter coupled F(4) gauged supergravity on a cornucopia of two-dimensional surfaces including a spindle, disc, domain wall and other novel backgrounds to four-dimensional minimal gauged supergravity. Using our consistent truncation we uplift known AdS2 × Σ1 solutions giving rise to four-dimensional orbifold solutions, AdS2 × Σ1 ⋉ Σ2. We further uplift our solutions to massive type IIA supergravity by constructing the full uplift formulae for six-dimensional U(1)2-gauged supergravity including all fields and arbitrary Romans mass and gauge coupling. The solutions we construct are naturally interpreted as the near-horizon geometries of asymptotically AdS6 black holes with a four-dimensional orbifold horizon. Alternatively, one may view them as the holographic duals of superconformal quantum mechanical theories constructed by compactifying five-dimensional USp(2N) theory living on a stack of D4-D8 branes on the four-dimensional orbifolds. As a first step to identifying these quantum mechanical theories we compute the Bekenstein-Hawking entropy holographically

Evaluation of automated calibration and quality control processes using the Aptio total laboratory automation system

Background The objective of this study was to determine whether manually performed calibration and quality control (QC) processes could be replaced with an automated laboratory system when installed analyzers fail to provide automated calibration and QC functions. Methods Alanine aminotransferase (ALT), total cholesterol (TC), creatinine (Cr), direct bilirubin (DB), and lipase (Lip) items were used as analytes. We prepared pooled serum samples at 10 levels for each test item and divided them into two groups; five for the analytical measurement range (AMR) group and five for the medical decision point (MDP) group. Calibration and QC processes were performed for five consecutive days, and ALT, TC, Cr, DB, and Lip levels were measured in the two groups using automated and manual methods. Precision and the mean difference between the calibration and QC methods were evaluated using the reported values of the test items in each group. Results Repeatability and within-laboratory coefficients of variation (CVs) between the automated system and the conventional manual system in the AMR group were similar. However, the mean reported values for test items were significantly different between the two systems. In the MDP group, repeatability and within-laboratory CVs were better with the automation system. All calibration and QC processes were successfully implemented with the Aptio total laboratory automation system. Conclusion The Aptio total laboratory automation system could be applied to routine practice to improve precision and efficiency

Holographic duals of M5-branes on an irregularly punctured sphere

Abstract We provide explicit holographic duals of M5-branes wrapped on a sphere with one irregular puncture and one regular puncture of arbitrary type. The solutions generalise the solutions corresponding to M5-branes wrapped on a disc recently constructed by Bah-Bonetti-Minasian-Nardoni by allowing for a general choice of regular puncture. We show that the central charges, flavour central charges and conformal dimensions of BPS operators match with a class of Argyres-Douglas theory

Thermodynamics of accelerating AdS 4_4 4 black holes from the covariant phase space

Abstract We study the charges and first law of thermodynamics for accelerating, non-rotating black holes with dyonic charges in AdS $$_4$$ 4 using the covariant phase space formalism. In order to apply the formalism to these solutions (which are asymptotically locally AdS and admit a non-smooth conformal boundary $${\mathscr {I}}$$ I ) we make two key improvements: (1) We relax the requirement to impose Dirichlet boundary conditions and demand merely a well-posed variational problem. (2) We keep careful track of the codimension-2 corner term induced by the holographic counterterms, a necessary requirement due to the presence of “cosmic strings” piercing $${\mathscr {I}}$$ I . Using these improvements we are able to match the holographic Noether charges to the Wald Hamiltonians of the covariant phase space and derive the first law of black hole thermodynamics with the correct “thermodynamic length” terms arising from the strings. We investigate the relationship between the charges imposed by supersymmetry and show that our first law can be consistently applied to various classes of non-supersymmetric solutions for which the cross-sections of the horizon are spindles

D4-branes wrapped on four-dimensional orbifolds through consistent truncation

Abstract We construct a consistent truncation of six-dimensional matter coupled F(4) gauged supergravity on a cornucopia of two-dimensional surfaces including a spindle, disc, domain wall and other novel backgrounds to four-dimensional minimal gauged supergravity. Using our consistent truncation we uplift known AdS2 × Σ1 solutions giving rise to four-dimensional orbifold solutions, AdS2 × Σ1 ⋉ Σ2. We further uplift our solutions to massive type IIA supergravity by constructing the full uplift formulae for six-dimensional U(1)2-gauged supergravity including all fields and arbitrary Romans mass and gauge coupling. The solutions we construct are naturally interpreted as the near-horizon geometries of asymptotically AdS6 black holes with a four-dimensional orbifold horizon. Alternatively, one may view them as the holographic duals of superconformal quantum mechanical theories constructed by compactifying five-dimensional USp(2N) theory living on a stack of D4-D8 branes on the four-dimensional orbifolds. As a first step to identifying these quantum mechanical theories we compute the Bekenstein-Hawking entropy holographically

Performance Comparison of SU- and MU-MIMO in 802.11ax: Delay and Throughput

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A High-Throughput Method for Cloning and Sequencing Human Immunodeficiency Virus Type 1 Integration Sites

Integration of retroviral DNA is nonspecific and can occur at many sites throughout chromosomes. However, the process is not uniformly distributed, and both hot and cold spots for integration exist. The mechanism that determines target site specificity is not well understood. Because of the nonspecific and widespread nature of integration, studies analyzing the mechanism and factors that control target site selection require the collection and analysis of a large library of human immunodeficiency virus type 1 (HIV-1) proviral clones. Such analyses are time-consuming and labor-intensive using conventional means. We have developed an efficient and high-throughput method of sequencing and mapping a large number of independent integration sites in the absence of any selection or bias. The new assay involves the use of a modified HIV-1 (NL-Mme) containing a type IIS restriction site, MmeI, at the right end of viral DNA. Digestion of genomic DNA from NL-Mme-infected cells generated viral DNA-containing fragments of a discrete size. Subsequent ligation-mediated PCR yielded short integration site fragments termed Int-tags, which were concatemerized for determining multiple integration sites in a single sequencing reaction. Analysis of chromosomal features and sequence preference associated with integration events confirmed the validity of the new high-throughput assay. The assay will aid the effort in understanding the mechanisms of target site selection during HIV-1 DNA integration, and the described methodology can be adapted easily to integration site studies involving other retroviruses and transposons