11,099 research outputs found
An experimental study on (2) modular symmetry in the quantum Hall system with a small spin-splitting
Magnetic-field-induced phase transitions were studied with a two-dimensional
electron AlGaAs/GaAs system. The temperature-driven flow diagram shows the
features of the (2) modular symmetry, which includes distorted
flowlines and shiftted critical point. The deviation of the critical
conductivities is attributed to a small but resolved spin splitting, which
reduces the symmetry in Landau quantization. [B. P. Dolan, Phys. Rev. B 62,
10278.] Universal scaling is found under the reduction of the modular symmetry.
It is also shown that the Hall conductivity could still be governed by the
scaling law when the semicircle law and the scaling on the longitudinal
conductivity are invalid. *corresponding author:[email protected]: The revised manuscript has been published in J. Phys.: Condens.
Matte
Finite-temperature magnetism of FePd and CoPt alloys
The finite-temperature magnetic properties of FePd and
CoPt alloys have been investigated. It is shown that the
temperature-dependent magnetic behaviour of alloys, composed of originally
magnetic and non-magnetic elements, cannot be described properly unless the
coupling between magnetic moments at magnetic atoms (Fe,Co) mediated through
the interactions with induced magnetic moments of non-magnetic atoms (Pd,Pt) is
included. A scheme for the calculation of the Curie temperature () for
this type of systems is presented which is based on the extended Heisenberg
Hamiltonian with the appropriate exchange parameters obtained from
{\em ab-initio} electronic structure calculations. Within the present study the
KKR Green's function method has been used to calculate the parameters.
A comparison of the obtained Curie temperatures for FePd and
CoPt alloys with experimental data shows rather good agreement.Comment: 10 pages, 12 figure
Robust and scalable rf spectroscopy in first-order magnetic sensitive states at second-long coherence time
Trapped-ion quantum sensors have become highly sensitive tools for the search
of physics beyond the Standard Model. Recently, stringent tests of local
Lorentz-invariance (LLI) have been conducted with precision spectroscopy in
trapped ions. We here elaborate on robust and scalable radio-frequency
composite-pulse spectroscopy at second long coherence times in the magnetic
sublevels of the long-lived state of a trapped Yb
ion. We compare two Ramsey-type composite rf pulse sequences, a generalized
spin-echo (GSE) sequence and a sequence based on universal rotations with 10
rephasing pulses (UR10) that decouple the energy levels from magnetic field
noise, enabling robust and accurate spectroscopy. Both sequences are
characterized theoretically and experimentally in the spin-$\
^{2}S_{1/2}^{172}^{+}^2F_{7/2}^2F_{7/2}2.5\,^{2}F_{7/2}\Theta\,=\,-0.0298(38)\,ea^{2}_{0}$
which is in agreement with the value deduced from clock measurements.Comment: 19 pages, 7 figure
Presynaptic actions of 4-Aminopyridine and γ-aminobutyric acid on rat sympathetic ganglia in vitro
Responses to bath-applications of 4-aminopyridine (4-AP) and -aminobutyric acid (GABA) were recorded intracellularly from neurones in the rat isolated superior cervical ganglion.
4-aminopyridine (0.1–1.0 mmol/l) usually induced spontaneous action potentials and excitatory postsynaptic potentials (EPSPs), which were blocked by hexamethonium. Membrane potential was unchanged; spike duration was slightly increased. Vagus nerve B-and C-fibre potentials were prolonged.
In 4-AP solution (0.1–0.3 mmol/l), GABA (0.1 mmol/l), 3-aminopropanesulphonic acid or muscimol evoked bursts of spikes and EPSPs in addition to a neuronal depolarization. These bursts, which were not elicited by glycine, glutamate, taurine or (±)-baclofen, were completely antagonised by hexamethonium, tetrodotoxin or bicuculline methochloride.
It is concluded that: (a) 4-AP has a potent presynaptic action on sympathetic ganglia; (b) presynaptic actions of GABA can be recorded postsynaptically in the presence of 4-AP; and (c) the presynaptic GABA-receptors revealed in this condition are similar to those on the postsynaptic membrane
Bistability in a 4-Level Laser with a Resonant Pump Mode
We investigate an optically pumped four-level laser in which both the laser and the pump form resonant cavity modes. We find that the system can exhibit absorptive bistability under conditions typical of solid-state lasers. Under conditions of high pump-cavity finesse, a bistability exists between below-threshold operation and maximum laser output
Nucleocytoplasmic Shuttling Modulates Activity and Ubiquitination-Dependent Turnover of SUMO-Specific Protease 2
Small ubiquitin-related modifier (SUMO) proteins are conjugated to numerous polypeptides in cells, and attachment of SUMO plays important roles in regulating the activity, stability, and subcellular localization of modified proteins. SUMO modification of proteins is a dynamic and reversible process. A family of SUMO-specific proteases catalyzes the deconjugation of SUMO-modified proteins. Members of the Sentrin (also known as SUMO)-specific protease (SENP) family have been characterized with unique subcellular localizations. However, little is known about the functional significance of or the regulatory mechanism derived from the specific localizations of the SENPs. Here we identify a bipartite nuclear localization signal (NLS) and a CRM1-dependent nuclear export signal (NES) in the SUMO protease SENP2. Both the NLS and the NES are located in the nonhomologous domains of SENP2 and are not conserved among other members of the SENP family. Using a series of SENP2 mutants and a heterokaryon assay, we demonstrate that SENP2 shuttles between the nucleus and the cytoplasm and that the shuttling is blocked by mutations in the NES or by treating cells with leptomycin B. We show that SENP2 can be polyubiquitinated in vivo and degraded through proteolysis. Restricting SENP2 in the nucleus by mutations in the NES impairs its polyubiquitination, whereas a cytoplasm-localized SENP2 made by introducing mutations in the NLS can be efficiently polyubiquitinated, suggesting that SENP2 is ubiquitinated in the cytoplasm. Finally, treating cells with MG132 leads to accumulation of polyubiquitinated SENP2, indicating that SENP2 is degraded through the 26S proteolysis pathway. Thus, the function of SENP2 is regulated by both nucleocytoplasmic shuttling and polyubiquitin-mediated degradation
Bifurcations and stability of gap solitons in periodic potentials
We analyze the existence, stability, and internal modes of gap solitons in
nonlinear periodic systems described by the nonlinear Schrodinger equation with
a sinusoidal potential, such as photonic crystals, waveguide arrays,
optically-induced photonic lattices, and Bose-Einstein condensates loaded onto
an optical lattice. We study bifurcations of gap solitons from the band edges
of the Floquet-Bloch spectrum, and show that gap solitons can appear near all
lower or upper band edges of the spectrum, for focusing or defocusing
nonlinearity, respectively. We show that, in general, two types of gap solitons
can bifurcate from each band edge, and one of those two is always unstable. A
gap soliton corresponding to a given band edge is shown to possess a number of
internal modes that bifurcate from all band edges of the same polarity. We
demonstrate that stability of gap solitons is determined by location of the
internal modes with respect to the spectral bands of the inverted spectrum and,
when they overlap, complex eigenvalues give rise to oscillatory instabilities
of gap solitons.Comment: 18 pages, 11 figures; updated bibliograph
Mirror matter admixtures in K_L \to \gamma\gamma
Based on possible albeit tiny, admixtures of mirror matter in ordinary mesons
we study the K_L \to \gamma\gamma transition. We find that this process can be
described with a small SU(3) symmetry breaking of only 3%. We also determine
the eta-eta' mixing angle and the pseudoscalar decay constants. The results for
these parameters are consistent with some obtained in the literature. They
favor two recent determinations; one based on two analytical constraints, and
another one based on next-to-leading order power corrections
Targeting Btk/Etk of prostate cancer cells by a novel dual inhibitor.
Btk and Etk/BMX are Tec-family non-receptor tyrosine kinases. Btk has previously been reported to be expressed primarily in B cells and has an important role in immune responses and B-cell malignancies. Etk has been shown previously to provide a strong survival and metastasis signal in human prostate cancer cells, and to confer androgen independence and drug resistance. While the role of Etk in prostate carcinogenesis is well established, the functions of Btk in prostate cancer have never been investigated, likely due to the perception that Btk is a hematopoietic, but not epithelial, kinase. Herein, we found that Btk is overexpressed in prostate cancer tissues and prostate cancer cells. The level of Btk in prostate cancer tissues correlates with cancer grades. Knockdown of Btk expression selectively inhibits the growth of prostate cancer cells, but not that of the normal prostate epithelial cells, which express very little Btk. Dual inhibition of Btk and Etk has an additive inhibitory effect on prostate cancer cell growth. To explore Btk and Etk as targets for prostate cancer, we developed a small molecule dual inhibitor of Btk and Etk, CTN06. Treatment of PC3 and other prostate cancer cells, but not immortalized prostate epithelial cells with CTN06 resulted in effective cell killing, accompanied by the attenuation of Btk/Etk signals. The killing effect of CTN06 is more potent than that of commonly used inhibitors against Src, Raf/VEGFR and EGFR. CTN06 induces apoptosis as well as autophagy in human prostate cancer cells, and is a chemo-sensitizer for docetaxel (DTX), a standard of care for metastatic prostate cancer patients. CTN06 also impeded the migration of human prostate cancer cells based on a 'wound healing' assay. The anti-cancer effect of CTN06 was further validated in vivo in a PC3 xenograft mouse model
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