Nutrigenomics and nutrigenetics

The nutrients are able to interact with molecular mechanisms and modulate the physiological functions in the body. The Nutritional Genomics focuses on the interaction between bioactive food components and the genome, which includes Nutrigenetics and Nutrigenomics. The influence of nutrients on f genes expression is called Nutrigenomics, while the heterogeneous response of gene variants to nutrients, dietary components and developing nutraceticals is called Nutrigenetics. Genetic variation is known to affect food tolerances among human subpopulations and may also influence dietary requirements and raising the possibility of individualizing nutritional intake for optimal health and disease prevention on the basis of an individual's genome. Nutrigenomics provides a genetic understanding for how common dietary components affect the balance between health and disease by altering the expression and/or structure of an individual's genetic makeup. Nutrigenetics describes that the genetic profile have impact on the response of body to bioactive food components by influencing their absorption, metabolism, and site of action. In this way, considering different aspects of gene-nutrient interaction and designing appropriate diet for every specific genotype that optimize individual health, diagnosis and nutritional treatment of genome instability, we could prevent and control conversion of healthy phenotype to diseases

Multi-BD Symbiotic Radio-Aided 6G IoT Network: Energy Consumption Optimization with QoS Constraint Approach

The commensal symbiotic radio (CSR) system is proposed as a novel solution for connecting systems through green communication networks. This system enables us to establish secure, ubiquitous, and unlimited connectivity, which is a goal of 6G. The base station uses MIMO antennas to transmit its signal. Passive IoT devices, called symbiotic backscatter devices (SBDs), receive the signal and use it to charge their power supply. When the SBDs have data to transmit, they modulate the information onto the received ambient RF signal and send it to the symbiotic user equipment, which is a typical active device. The main purpose is to enhance energy efficiency in this network by minimizing energy consumption (EC) while ensuring the minimum required throughput for SBDs. To achieve this, we propose a new scheduling scheme called Timing-SR that optimally allocates resources to SBDs. The main optimization problem involves non-convex objective functions and constraints. To solve this, we use mathematical techniques and introduce a new approach called sequential quadratic and conic quadratic representation to relax and discipline the problem, leading to reducing its complexity and convergence time. The simulation results demonstrate that the proposed approach outperforms other outlined schemes in reducing EC

Correlation between Gingival Expression of STAT1 and Chronic Periodontitis

Background: Periodontal disease is a most common inflammatory disease of periodontium. A wide variety of cytokines, chemokines and receptors are synthesized by gingival fibroblasts and inflammatory cells. Signal Transducer and Activator of Transcription-1 (STAT)-1 is a transcription factor that plays a key role in the process of intracellular signal transduction through the JAK-STAT pathway in response to inflammatory cytokines, Therefore plays an important role in inflammatory diseases. So the aim of this study was to determine the correlation between STAT1 gingival gene expression and chronic periodontitis. Materials and Methods: For this purpose, gingival tissue sample were collected from 20 individuals with clinically healthy gingiva and 25 patients with moderate to severe chronic periodontitis. After homogenizing the gingival tissues, RNA was extracted by RNA isolation kit. After synthesis of cDNA, expression of STAT1 was evaluated by Real-time PCR. Results: Higher expression of STAT1 was found in chronic periodontitis in comparison to clinically healthy gingiva (P<0.001). Conclusion: In this study, STAT1 mRNA was significantly up-regulated in chronic periodontitis tissues as compared to healthy control tissues. These results suggest that the modulation of STAT1 expression may play an important role in the pathogenesis of the periodontal inflammatory process

Parameters of lower extremities alignment view in Iranian adult population

Normal axial alignment restoration in lower extremities is crucial for surgeons performing reconstructive surgeries. Since reference normal values of axial alignment are affected by age, sex, and ethical issues, we tried to scrutinize these parameters in Iranian adults and compare them with normal values in literatures. Through a cross-sectional design, standing axial alignment views of lower extremities were surveyed from 100 volunteers (50 males and 50 females) aged between 15-32 years. The lower extremities alignment variables were evaluated during two separate measurements. Total average values were used for comparison among genders. Tibiofemoral mechanical angle depicted mean varus of 1.5 degrees in an Iranian population that was significantly higher in male participants. The Mean angle between anatomical and mechanical axes of the femur was 5.7 ± 1.2º. The Knee joint was shown to be medially inclined 3.6 ± 1.7º in men comparing 2 ± 2º of women with a significant difference. Joint line congruence angle was medially inclined in all of the study participants with a mean of 1 ± 1.6º. To compare with anthropometric studies of western populations, Iranian participants had more varus lower limb alignment. It seemed mainly because of larger medially inclined knee joint (knee-joint obliquity). This finding along with more compensatory ankle valgus is similar to results of other Asian studies. Such racial variation should be considered in designing appropriate systems in reconstructive surgery. © 2015 Tehran University of Medical Sciences. All rights reserved

Parameters of lower extremities alignment view in Iranian adult population

Normal axial alignment restoration in lower extremities is crucial for surgeons performing reconstructive surgeries. Since reference normal values of axial alignment are affected by age, sex, and ethical issues, we tried to scrutinize these parameters in Iranian adults and compare them with normal values in literatures. Through a cross-sectional design, standing axial alignment views of lower extremities were surveyed from 100 volunteers (50 males and 50 females) aged between 15-32 years. The lower extremities alignment variables were evaluated during two separate measurements. Total average values were used for comparison among genders. Tibiofemoral mechanical angle depicted mean varus of 1.5 degrees in an Iranian population that was significantly higher in male participants. The Mean angle between anatomical and mechanical axes of the femur was 5.7 ± 1.2º. The Knee joint was shown to be medially inclined 3.6 ± 1.7º in men comparing 2 ± 2º of women with a significant difference. Joint line congruence angle was medially inclined in all of the study participants with a mean of 1 ± 1.6º. To compare with anthropometric studies of western populations, Iranian participants had more varus lower limb alignment. It seemed mainly because of larger medially inclined knee joint (knee-joint obliquity). This finding along with more compensatory ankle valgus is similar to results of other Asian studies. Such racial variation should be considered in designing appropriate systems in reconstructive surgery

Transcriptional interference by RNA polymerase III affects expression of the Polr3e gene.

Overlapping gene arrangements can potentially contribute to gene expression regulation. A mammalian interspersed repeat (MIR) nested in antisense orientation within the first intron of the Polr3e gene, encoding an RNA polymerase III (Pol III) subunit, is conserved in mammals and highly occupied by Pol III. Using a fluorescence assay, CRISPR/Cas9-mediated deletion of the MIR in mouse embryonic stem cells, and chromatin immunoprecipitation assays, we show that the MIR affects Polr3e expression through transcriptional interference. Our study reveals a mechanism by which a Pol II gene can be regulated at the transcription elongation level by transcription of an embedded antisense Pol III gene