Synthesis of a novel monomer “DDTU-IDI” for the development of low-shrinkage dental resin composites

ObjectiveThe current dental resin composites often suffer from polymerization shrinkage, which can lead to microleakage and potentially result in recurring tooth decay. This study presents the synthesis of a novel monomer, (3,9-diethyl-1,5,7,11-tetraoxaspiro[5,5]undecane-3,9-diyl)bis(methylene) bis((2-(3-(prop-1-en-2-yl)phenyl)propan-2-yl)carbamate) (DDTU-IDI), and evaluates its effect in the formulation of low-shrinkage dental resin composites.MethodsDDTU-IDI was synthesized through a two-step reaction route, with the initial synthesis of the required raw material monomer 3,9-diethyl-3,9-dihydroxymethyl-1,5,7,11-tetraoxaspiro-[5,5] undecane (DDTU). The structures were confirmed using Fourier-transform infrared (FT-IR) spectroscopy and hydrogen nuclear magnetic resonance (1HNMR) spectroscopy. Subsequently, DDTU-IDI was incorporated into Bis-GMA-based composites at varying weight percentages (5, 10, 15, and 20 wt%). The polymerization reaction, degree of conversion, polymerization shrinkage, mechanical properties, physicochemical properties and biocompatibility of the low-shrinkage composites were thoroughly evaluated. Furthermore, the mechanical properties were assessed after a thermal cycling test with 10,000 cycles to determine the stability.ResultsThe addition of DDTU-IDI at 10, 15, and 20 wt% significantly reduced the polymerization volumetric shrinkage of the experimental resin composites, without compromising the degree of conversion, mechanical and physicochemical properties. Remarkably, at a monomer content of 20 wt%, the polymerization shrinkage was reduced to 1.83 ± 0.53%. Composites containing 10, 15, and 20 wt% DDTU-IDI exhibited lower water sorption and higher contact angle. Following thermal cycling, the composites exhibited no significant decrease in mechanical properties, except for the flexural properties.Significance. DDTU-IDI has favorable potential as a component which could produce volume expansion and increase rigidity in the development of low-shrinkage dental resin composites. The development of low-shrinkage composites containing DDTU-IDI appears to be a promising strategy for reducing polymerization shrinkage, thereby potentially enhancing the longevity of dental restorations

Interplay of disorder and magnetic field in the superconducting vortex state

We calculate the density of states of an inhomogeneous superconductor in a magnetic field where the positions of vortices are distributed completely at random. We consider both the cases of s-wave and d-wave pairing. For both pairing symmetries either the presence of disorder or increasing the density of vortices enhances the low energy density of states. In the s-wave case the gap is filled and the density of states is a power law at low energies. In the d-wave case the density of states is finite at zero energy and it rises linearly at very low energies in the Dirac isotropic case (\alpha_D=t/\Delta_0=1, where t is the hopping integral and \Delta_0 is the amplitude of the order parameter). For slightly higher energies the density of states crosses over to a quadratic behavior. As the Dirac anisotropy increases (as \Delta_0 decreases with respect to the hopping term) the linear region decreases in width. Neglecting this small region the density of states interpolates between quadratic and back to linear as \alpha_D increases. The low energy states are strongly peaked near the vortex cores.Comment: 12 REVTeX pages, 15 figure

Semiclassical theory of transport in a random magnetic field

We study the semiclassical kinetics of 2D fermions in a smoothly varying magnetic field $B({\bf r})$. The nature of the transport depends crucially on both the strength $B_0$ of the random component of $B({\bf r})$ and its mean value $\bar{B}$. For $\bar{B}=0$, the governing parameter is $\alpha=d/R_0$, where $d$ is the correlation length of disorder and $R_0$ is the Larmor radius in the field $B_0$. While for $\alpha\ll 1$ the Drude theory applies, at $\alpha\gg 1$ most particles drift adiabatically along closed contours and are localized in the adiabatic approximation. The conductivity is then determined by a special class of trajectories, the "snake states", which percolate by scattering at the saddle points of $B({\bf r})$ where the adiabaticity of their motion breaks down. The external field also suppresses the diffusion by creating a percolation network of drifting cyclotron orbits. This kind of percolation is due only to a weak violation of the adiabaticity of the cyclotron rotation, yielding an exponential drop of the conductivity at large $\bar{B}$. In the regime $\alpha\gg 1$ the crossover between the snake-state percolation and the percolation of the drift orbits with increasing $\bar{B}$ has the character of a phase transition (localization of snake states) smeared exponentially weakly by non-adiabatic effects. The ac conductivity also reflects the dynamical properties of particles moving on the fractal percolation network. In particular, it has a sharp kink at zero frequency and falls off exponentially at higher frequencies. We also discuss the nature of the quantum magnetooscillations. Detailed numerical studies confirm the analytical findings. The shape of the magnetoresistivity at $\alpha\sim 1$ is in good agreement with experimental data in the FQHE regime near $\nu=1/2$.Comment: 22 pages REVTEX, 14 figure

A Generative and Mutational Approach for Synthesizing Bug-exposing Test Cases to Guide Compiler Fuzzing

Random test case generation, or fuzzing, is a viable means for uncovering compiler bugs. Unfortunately, compiler fuzzing can be time-consuming and inefficient with purely randomly generated test cases due to the complexity of modern compilers. We present ComFuzz, a focused compiler fuzzing framework. ComFuzz aims to improve compiler fuzzing efficiency by focusing on testing components and language features that are likely to trigger compiler bugs. Our key insight is human developers tend to make common and repeat errors across compiler implementations; hence, we can leverage the previously reported buggy-exposing test cases of a programming language to test a new compiler implementation. To this end, ComFuzz employs deep learning to learn a test program generator from open-source projects hosted on GitHub. With the machinegenerated test programs in place, ComFuzz then leverages a set of carefully designed mutation rules to improve the coverage and bug-exposing capabilities of the test cases. We evaluate ComFuzz on 11 compilers for JS and Java programming languages. Within 260 hours of automated testing runs, we discovered 33 unique bugs across nine compilers, of which 29 have been confirmed and 22, including an API documentation defect, have already been fixed by the developers. We also compared ComFuzz to eight prior fuzzers on four evaluation metrics. In a 24-hour comparative test, ComFuzz uncovers at least 1.5× more bugs than the state-of-the-art baselines

Slater-Pauling Behavior of the Half-Ferromagnetic Full-Heusler Alloys

Using the full-potential screened Korringa-Kohn-Rostoker method we study the full-Heusler alloys based on Co, Fe, Rh and Ru. We show that many of these compounds show a half-metallic behavior, however in contrast to the half-Heusler alloys the energy gap in the minority band is extremely small. These full-Heusler compounds show a Slater-Pauling behavior and the total spin-magnetic moment per unit cell (M_t) scales with the total number of valence electrons (Z_t) following the rule: M_t=Z_t-24. We explain why the spin-down band contains exactly 12 electrons using arguments based on the group theory and show that this rule holds also for compounds with less than 24 valence electrons. Finally we discuss the deviations from this rule and the differences compared to the half-Heusler alloys.Comment: 10 pages, 8 figures, revised figure 3, new text adde

Three chromosome-scale Papaver genomes reveal punctuated patchwork evolution of the morphinan and noscapine biosynthesis pathway

Papaver species P. setigerum, P. rhoeas, and P. somniferum accumulates different levels of morphine and noscapine. Here, the authors report the improved genome assembly of P. somniferum and de novo assembly of the other two species, and reveal the evolution of the benzylisoquinoline alkaloids biosynthetic pathway.For millions of years, plants evolve plenty of structurally diverse secondary metabolites (SM) to support their sessile lifestyles through continuous biochemical pathway innovation. While new genes commonly drive the evolution of plant SM pathway, how a full biosynthetic pathway evolves remains poorly understood. The evolution of pathway involves recruiting new genes along the reaction cascade forwardly, backwardly, or in a patchwork manner. With three chromosome-scale Papaver genome assemblies, we here reveal whole-genome duplications (WGDs) apparently accelerate chromosomal rearrangements with a nonrandom distribution towards SM optimization. A burst of structural variants involving fusions, translocations and duplications within 7.7 million years have assembled nine genes into the benzylisoquinoline alkaloids gene cluster, following a punctuated patchwork model. Biosynthetic gene copies and their total expression matter to morphinan production. Our results demonstrate how new genes have been recruited from a WGD-induced repertoire of unregulated enzymes with promiscuous reactivities to innovate efficient metabolic pathways with spatiotemporal constraint.Computer Science

Measurements of the observed cross sections for exclusive light hadron production in e^+e^- annihilation at \sqrt{s}= 3.773 and 3.650 GeV

By analyzing the data sets of 17.3 pb$^{-1}$ taken at $\sqrt{s}=3.773$ GeV and 6.5 pb$^{-1}$ taken at $\sqrt{s}=3.650$ GeV with the BESII detector at the BEPC collider, we have measured the observed cross sections for 12 exclusive light hadron final states produced in $e^+e^-$ annihilation at the two energy points. We have also set the upper limits on the observed cross sections and the branching fractions for $\psi(3770)$ decay to these final states at 90% C.L.Comment: 8 pages, 5 figur

Search for the Rare Decays J/Psi --> Ds- e+ nu_e, J/Psi --> D- e+ nu_e, and J/Psi --> D0bar e+ e-

We report on a search for the decays J/Psi --> Ds- e+ nu_e + c.c., J/Psi --> D- e+ nu_e + c.c., and J/Psi --> D0bar e+ e- + c.c. in a sample of 5.8 * 10^7 J/Psi events collected with the BESII detector at the BEPC. No excess of signal above background is observed, and 90% confidence level upper limits on the branching fractions are set: B(J/Psi --> Ds- e+ nu_e + c.c.)<4.8*10^-5, B(J/Psi --> D- e+ nu_e + c.c.) D0bar e+ e- + c.c.)<1.1*10^-5Comment: 10 pages, 4 figure