Design of a ROIC for scanning type HgCdTe LWIR focal plane arrays

Design of a silicon readout integrated circuit (ROIC) for LWIR HgCdTe Focal Plane is presented. ROIC incorporates time delay integration (TDI) functionality over seven elements with a supersampling rate of three, increasing SNR and the spatial resolution. Novelty of this topology is inside TDI stage; integration of charges in TDI stage implemented in current domain by using switched current structures that reduces required area for chip and improves linearity performance. ROIC, in terms of functionality, is capable of bidirectional scan, programmable integration time and 5 gain settings at the input. Programming can be done parallel or serially with digital interface. ROIC can handle up to 3.5V dynamic range with the input stage to be direct injection (DI) type. With the load being 10pF capacitive in parallel with 1MΩ resistance, output settling time is less than 250nsec enabling the clock frequency up to 4MHz. The manufacturing technology is 0.35μm, double poly-Si, four-metal (3 metals and 1 top metal) 5V CMOS process

Modified autologous transobturator tape surgery — evaluation of short term results

Objectives: The aim of this study is to evaluate the short-term outcomes of our modified autologous transobturator tape(aTOT) technique with rectus abdominis muscle fascial graft for the treatment of female stress urinary incontinence (SUI).Material and methods: The data of 22 patients who underwent modified aTOT were recorded. Perioperative data regardingoperative time, complications and postoperative visual analogue scores were noted. Patients were assessed 18 monthsafter surgery. The primary endpoints of this study were the improvements in the International Consultation on IncontinenceQuestionnaire-Female Lower Urinary Tract Symptoms (ICIQ-FLUTS) subscores, one-hour pad test and cough stress testrates as an objective cure as well as the improvements in the PGI-I and ICIQ-FLUTS quality of life scores as a subjective cure.Results: Mean age and the mean follow-up period were 51.7 ± 9.8 years and 20.1 ± 0.9 months, respectively. Urethralhypermobility and a positive cough stress test were detected in all the patients. Mean operative time was 43.8 ± 8.1 min.and the overall complication rate was 9%. Mean VAS scores at postoperative 24 hours were 2.6 ± 1.2. At the postoperativeeighteenth month, no patient had a positive cough test and mean PGI-I score was 2 while two patients had moderateurinary incontinence according to the pad test. Pad test results, ICIQ subscores of voiding QoL, incontinence, incontinenceQoL, total score and total QoL score at baseline and eighteen months after surgery were 76.9 ± 19.9, 9.6 ± 4.1, 15.5 ± 4.0,39.5 ± 7.9, 27.9 ± 6.6, 68.4 ± 13.8 and 7.1 ± 2, 10.1 ± 2.4, 6.6 ± 2.1, 13.4 ± 4.5, 20.4 ± 4.8, 39.7 ± 9.2 respectively (p = 0.001,p = 0.004, p = 0.001, p = 0.001, p = 0.001, and p = 0.001, respectively)Conclusions: Modified aTOT is an effective and safe method with low morbidity for SUI treatment in short term

Digital pixel readout integrated circuit architectures for LWIR

This paper presents and discusses digital pixel readout integrated circuit architectures for long wavelength infrared (LWIR) in CMOS technology. Presented architectures are designed for scanning and staring arrays type detectors respectively. For scanning arrays, digital time delay integration (TDI) is implemented on 8 pixels with sampling rate up to 3 using CMOS 180nm technology. Input referred noise of ROIC is below 750 rms electron meanwhile power dissipation is appreciably under 30mW. ROIC design is optimized to perform at room as well as cryogenic temperatures. For staring type arrays, a digital pixel architecture relying on coarse quantization with pulse frequency modulation (PFM) and novel approach of extended integration is presented.. It can achieve extreme charge handling capacity of 2.04Ge(-) with 20 bit output resolution and power dissipation below 350 nW in CMOS 90nm technology. Efficient mechanism of measuring the time to estimate the remaining charge on integration capacitor in order to achieve low SNR has employed

Low-power LVDS for digital readout circuits

This paper presents a mixed-signal LVDS driver in 90 nm CMOS technology. The designed LVDS core is to be used as a data link between Infrared Focal Plane Array (IRFPA) detector end and microprocessor input. Parallel data from 220 pixels of IRFPA is serialized by LVDS driver and read out to microprocessor. It also offers a reduced power consumption rate, high data transmission speed and utilizes dense placement of devices for area efficiency. The entire output driver circuit including input buffer draws 5mA while the output swing is 500mV at power supply of 1.2V for data rate of 6.4Gbps. Total LVDS chip area is 0.79 mm(2). Due to these features, the designed LVDS driver is suitable for purposes such as portable, high-speed imaging

Cryogenic measurements of a digital pixel readout integrated circuit for LWIR

This paper presents and discusses the cryogenic temperature (77K) measurement results of a digital readout integrated circuit (DROIC) for a 32x32 long wavelength infrared pixel sensor array designed in 90nm CMOS process. The chip achieves a signal-to-noise ratio (SNR) of 58dB with a charge handling capacity of 2.03Ge- at cryogenic temperature with 1.3mW of power dissipation. The performance of the readout is discussed in terms of power dissipation, charge handling capacity and SNR considering the fact that the process library models are not optimized for cryogenic temperature operation of the Metal-Oxide-Semiconductor (MOS) devices. These results provide an insight to foresee the design confrontations due to non-optimized device models for cryogenic temperatures particularly for short channel devices

SUCI02 inhibits the erbB-2 tyrosine kinase receptor signaling pathway and arrests the cell cycle in G 1 phase in breast cancer cells

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73321/1/j.1349-7006.2006.00143.x.pd

A low-power CMOS readout IC with on-chip column-parallel SAR ADCs for microbolometer applications

A readout IC (ROIC) designed for high temperature coefficient of resistance (TCR) SiGe microbolometers is presented. The ROIC is designed for higher Ge content SiGe microbolometers which have higher detector resistance (∼1MΩ) and higher TCR values (∼%5.5/K). The ROIC includes column SAR ADCs for on-chip column-parallel analog to digital conversion. SAR ADC architecture is chosen to reduce the overall power consumption. The problem of resistance variation across the bolometers which introduce fixed pattern noise is addressed by setting a tunable reference resistor shared for each column which can be calibrated offline to set the common-mode level. Moreover, column non-uniformity has been reduced through comparator offset compensation in the SAR ADC. The columnwise architecture in this work reduces the number of integrators needed in the architecture and enables 17×17 μm2 pixel sizes. The prototype has been designed and fabricated in 0.25-μm CMOS process

Success of microvascular surgery; repair mesenteric injury and prevent short bowel syndrome: a case report

This is an Open Access article distributed under the terms of the Creative Commons Attribution Licens

Minimally invasive treatment of patients with bronchobiliary fistula: a case series

<p>Abstract</p> <p>Introduction</p> <p>Bronchobiliary fistula is an uncommon complication secondary to hepatobiliary surgery. Bilioptysis is a pathognomic finding for bronchobiliary fistulas. Diagnosis may be easily established in the light of clinical history, which can be aided by imaging studies to pinpoint the exact location. Some diagnostic procedures such as endoscopic retrograde cholangiopancreatectomy are also useful for treatment.</p> <p>Case presentation</p> <p>We present three Turkish patients with bronchobiliary fistula secondary to previous hepatic surgery due to hydatid cyst in two, a 19-year-old and a 47-year-old man, and iatrogenic trauma of the common bile duct by endoscopy in a 35-year-old man. All of the patients were successfully treated by minimally invasive methods including percutaneous drainage and endoscopic retrograde cholangiopancreatography.</p> <p>Conclusion</p> <p>We suggest that bronchobiliary fistula could be managed through conservative treatment methods which do not require in-hospital follow-up, particularly in uncomplicated cases. Otherwise, surgical management can be unavoidable.</p

Effect of Mitomycin - C and Triamcinolone on Preventing Urethral Strictures

Urethral stricture is a common disease with high recurrence rate. Several manipulations were defined to prevent the recurrence but the results were disappointing. This study aimed to evaluate the efficacy of triamcinolone and mitomycin-C on urethral stricture formation and their effect on inhibition of urethral fibrosis. A total of 24 New Zealand rabbits were divided into 3 groups. Urethras of rabbits were traumatized with pediatric resectoscope. Resection area was irrigated with 10mL saline, swapped with a cotton wool soaked with 0.5mg/mL MMC and injected by 40mg triamcinolone in groups 1, 2 and 3 respectively. Retrograde urethrogram was performed at 28th day of procedure and the urethra was removed for histopathologic evaluation. There were significant differences in urethral diameters and in lumen reduction rate between the control and study groups (p< 0.001). Compared to control group, all treatment groups showed mild fibrosis, less collagen bundle irregularity, and lower numbers of fibroblasts (p= 0.003). The Tunnel assay showed that the number of apoptotic cells in the submucosal connective tissue was quantitatively higher in control groups (p= 0.034). In the view of efficacy and safety, MMC and triamcinolone have the potential to replace the use of stents, clean intermittent catheterization, or long term catheters following internal urethrotomy. There were no statistically significant differences between two agents in terms of preventing urethral stricture formation in the present study. Mitomycin C and triamcinolone decreased the recurrence rates of urethral stricture